This paper overviewed theoretical basis, clinical evidence and clinical practice principles of antiplatelet therapy in patients with hypertension to draw attention to take appropriate risk stratification, rigorous screening for bleeding cases and to administer aspirin with appropriate dose in daily clinical practice.
Background: Diabetic cardiomyopathy is an important complication of type 2 diabetics. The role of immunoinflammation, immunity, and diet has not been adequately clarified.
Objective: We investigated the relationships between diabetic cardiomyopathy and immuno-inflammation, as well as immunity and diets.
Methods: Sixty Sprague-Dawley (SD) male rats were included in this study, from which 12 were randomly selected as the normal control group (group A) and of which the remaining 48 were considered as the type 2 diabetes mellitus (T2DM) model group. Group A was fed with common diets and the T2DM model group, with high-glucose diets (by adding 20% cane sugar, 10% lard, and 2.5% cholesterol into a 67.5% common diet). After 4-week feeding, the T2DM model group was randomly allocated into three groups according to the diet, highfat diet group (group B), common diet group (group C), and low-fat diet group (group D). All the three groups were then fed for another 10 weeks. At the end of the experiment, body weight, random blood glucose levels, and cardiac weight were measured. Left ventricular tissue was obtained for light microscopy and electron microscopy. Deposits of immunoglobulin G (IgG) in myocardium were identified by immunohistochemistry. Serum levels of high-sensitivity C-reactive protein (hs-CRP) were determined using the enzyme-linked immunosorbent assay (ELISA). All data were statistically analyzed.
Results: The serum level of hs-CRP was significantly higher in groups B, C, and D, than in the control group. Therefore, IgG deposits among cardiac muscle cells were observed in all the model groups, significant deviations were noted in group A (p <0.01) and IgG deposits were less in group D than in groups B and C (p <0.01).
Conclusion: Immuno-inflammation participates in the development of T2DM and diabetic cardimyopathy. Immune injury can be alleviated following dietary interference.
Ferroelectric composite thin films of x-SBT/PVDF with different SBT content (weight ratios of SBT to PVDF, x = 0 %, 5 %, 10 %, 15 %, 20 %) were prepared by spin-coating method. The crystal structures of x-SBT/PVDF films were analyzed by X-ray diffraction (XRD) measurements and Fourier transform-infrared spectroscopy (FT-IR), respectively. Experimental results demonstrated that both α, β-phases PVDF and the layered perovskite SBT co-existed in the x-SBT/PVDF samples. With an increase of SBT content in the x-SBT/PVDF thin films, both the dielectric constant and the saturated polarization were also increased, compared with those of pure PVDF thin film. More importantly, when the SBT content in the x-SBT/PVDF thin films was larger than 15 %, the coercive field of x-SBT/PVDF thin films was also decreased.
A Nonlinear Proportional-Derivative (NPD) controller with gravity compensation is proposed and applied to robot manipulators in this paper. The proportional and derivative gains are changed by the nonlinear function of errors in the NPD controller. The closed-loop system, composed of nonlinear robot dynamics and NPD controllers, is globally asymptotically stable in position control of robot manipulators. The comparison of the simulation experiments in the position control (the step response) of a robot manipulator with two degrees of freedom is also presented to illustrate that the NPD controller is superior to the conventional PD controller in a position control system. The experimental results show that the NPD controller can obtain a faster response velocity and higher position accuracy than the conventional PD controller in the position control of robot manipulators because the proportional and derivative gains of the NPD controller can be changed by the nonlinear function of errors. The NPD controller provides a novel approach for robot control systems.
In this work, new experimental value for water content in sour natural gas were reported. In addition, to predict the water content in sour natural gas, a modified cubic plus association equation of state (CPA-EoS) was also proposed. In this model, a new energy parameter a was proposed to make an accurate description of saturated liquid density. Additionally, a temperature dependent binary interaction parameter kij for six binary systems was also obtained. Lastly, a comparison between the prediction results of the modified CPA-EoS and the experimental data was presented, and the results showed that the modified CPA-EoS could predict the water content in sour natural gas with high accuracy, which has an AAD of 3.6722% with experimental data in literatures and an AAD of 1.946% for experimental data reported in this work.
On 5 October 2015, the Trans-Pacific Partnership Agreement (TPP) led by the U.S. was signed. Already, 12 countries1 have joined the agreement, but China has not. Thus, lots of research has focused on the negative effect of the TPP on China’s foreign trade. On the other hand, China is moving forward in its own efforts to establish bilateral free trade agreements (FTAs) and free trade zones. In June 2015, China-South Korea and China-Australia signed bilateral FTAs which went into effect in December 2015. Several questions were raised: Since South Korea and Australia are the major trade partners in the Pacific area and the bilateral FTAs will be effective before the TPP, will these FTAs’ positive effects on China’s foreign trade offset some of the negative effects of the TPP? If China and the U.S. adopted a competitive trade policy, which countries would benefit? If China and the U.S. adopted a cooperative trade policy, how would the trade value and economic welfare change? This paper simulates and analyses the mutual effects of China-South Korea and China-Australia FTAs and the enlarging TPP using the computable general equilibrium model. The major conclusions drawn suggest that China-South Korea and China-Australia FTAs will significantly offset the TPP’s negative effect on China’s foreign trade. If China is not included, the U.S. economic benefit from the TPP will be limited. The economic welfare for a country like Australia, which joined both the bilateral FTA and the TPP, will be increased the most. In the long run, China joining the TPP would be the most beneficial decision for its national interest. However, if the TPP cannot be approved by the US congress, the U.S.’s economic indicators and export would be decreasing sharply. China’s economy and export will benefit from FTAs.
To summarize the research progress of music therapy in hospice care and to provide reference for further research.
A wide range of literatures on music therapy and hospice care at home and abroad were searched and read, and the literature was integrated, judged, analyzed, and summarized.
The related research on music therapy in hospice care mainly focused on western developed countries such as Europe and the United States. China is still in the stage of theoretical exploration, lacking qualitative research based on case investigation and empirical research based on data statistics.
Music therapy supports the management of symptoms in hospice care, which can meet the diverse needs of patients and their family members including physical, psychological, social, and spiritual.
Dynamic properties are vital for the working reliability of aft stern tube bearings. However, the determination of such properties currently involves several simplifications and assumptions. To obtain its dynamic characteristics accurately, the aft stern tube bearing was divided into several bearing segments. The oil film reaction force was considered in the calculation of shaft alignment, and the journal deflection and actual oil film thickness were obtained accordingly. Subsequently, the perturbed Reynolds equation was solved using the finite difference method when the dynamic characteristics of journal bearings with finite width were evaluated. Then, a calculation program was developed and verified by comparing with the results of other studies. Finally, the dynamic characteristics were calculated under different revolutions. The results showed that the stiffness at the vertical direction of the aft stern tube bearing was several times that of the horizontal direction and varied with the revolutions of the shafting system. These findings can provide the foundation for the precise calculation of the journal trajectory under dynamic conditions, as well as for the evaluation of the oil film thickness. Moreover, the results led to favorable conditions for the accurate calculation of the shafting whirling vibration.
Introduction: A real-time RT-PCR method for identification and quantification of porcine epidemic diarrhoea virus (PEDV) strains in China was developed.
Material and Methods: Based on the conserved sequence of the PEDV nucleocapsid (N) gene, a primer pair and probe were designed to establish a TaqMan-MGB real-time RT-PCR assay for quantitative detection of the virus. The sequence was cloned into the pMD18-T vector and a series of diluted recombinant plasmids were used to generate a standard curve with an R2 value of 0.999.
Results: The developed quantitative PCR assay detected viral titres as low as 0.1 TCID50 with high specificity and no cross-reaction with other porcine viruses (PoRV, TGEV, PRRSV, or CSFV). The intra-batch and inter-batch coefficients of variation were both less than 1%, which indicated good reproducibility. Thirty clinical diarrhoea samples obtained from pigs in Shanghai and Fujian were analysed using this quantitative PCR assay. Out of these samples, 93.3% were found to be PEDV positive.
Conclusion: This approach is suitable for clinical sample identification and pathogenesis studies.
It has been suggested that the standardized growth curve (SGC) method can be used to accurately determinate equivalent dose (De) and reduce measurement time. However, different opinions regarding the applicability of the SGC method exist. In this paper, we evaluated quartz OSL SGCs of marine and coastal sediments of different grain sizes and different cores in the south Bohai Sea in China, and tested their applicability to the determination of De values. Our results suggested as follows: (1) The SGC method is applicable to both multiple- and single-aliquot regenerative-dose (MAR and SAR) protocols of OSL dating and efficiently provides reliable estimates of De. (2) Finesand quartz of different palaeodoses showed highly similar dose-response curves and an SGC was developed, but old samples using the SGC method have large uncertainties. (3) For coarse-silt quartz, two different types of dose-response curves were recorded: low-dose (≤60Gy) and high-dose (≥100Gy). The growth curves of low-dose quartz were similar to each other, facilitating the use of SGC in De estimations, but errors tended to be larger than those obtained in the SAR method. For high-dose (100–300Gy) quartz, the SGC was also found to be reliable, but there was large uncertainty in De (>300Gy) estimation. We suggest that SGC could be employed for the dating of marine and coastal sediments dating using either MAR or SAR OSL protocol and either fine-silt, coarse-silt or fine-sand quartz.