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Guo-Jun Yang

Abstract

This paper overviewed theoretical basis, clinical evidence and clinical practice principles of antiplatelet therapy in patients with hypertension to draw attention to take appropriate risk stratification, rigorous screening for bleeding cases and to administer aspirin with appropriate dose in daily clinical practice.

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Xiao-Jun Yang, Dumitru Baleanu and J. A. Tenreiro Machado

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Carlo Cattani, H. M. Srivastava and Xiao-Jun Yang

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Mohamad Rafi Segi Rahmat, Dumitru Baleanu and Xiao-Jun Yang

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H. M. Srivastava, J. A. Tenreiro Machado and Xiao-Jun Yang

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Xiu-lan Zou, Jun Yang, Jian-ming Yang, Yan-qun Liu, Wen Wang, Jun Zheng, Bao-hua Ma and Fang-yuan Chen

Abstract

Background: Diabetic cardiomyopathy is an important complication of type 2 diabetics. The role of immunoinflammation, immunity, and diet has not been adequately clarified.

Objective: We investigated the relationships between diabetic cardiomyopathy and immuno-inflammation, as well as immunity and diets.

Methods: Sixty Sprague-Dawley (SD) male rats were included in this study, from which 12 were randomly selected as the normal control group (group A) and of which the remaining 48 were considered as the type 2 diabetes mellitus (T2DM) model group. Group A was fed with common diets and the T2DM model group, with high-glucose diets (by adding 20% cane sugar, 10% lard, and 2.5% cholesterol into a 67.5% common diet). After 4-week feeding, the T2DM model group was randomly allocated into three groups according to the diet, highfat diet group (group B), common diet group (group C), and low-fat diet group (group D). All the three groups were then fed for another 10 weeks. At the end of the experiment, body weight, random blood glucose levels, and cardiac weight were measured. Left ventricular tissue was obtained for light microscopy and electron microscopy. Deposits of immunoglobulin G (IgG) in myocardium were identified by immunohistochemistry. Serum levels of high-sensitivity C-reactive protein (hs-CRP) were determined using the enzyme-linked immunosorbent assay (ELISA). All data were statistically analyzed.

Results: The serum level of hs-CRP was significantly higher in groups B, C, and D, than in the control group. Therefore, IgG deposits among cardiac muscle cells were observed in all the model groups, significant deviations were noted in group A (p <0.01) and IgG deposits were less in group D than in groups B and C (p <0.01).

Conclusion: Immuno-inflammation participates in the development of T2DM and diabetic cardimyopathy. Immune injury can be alleviated following dietary interference.

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Li Hua-Wu, Ma Hong-Xing, Jiang Jian-Feng, Yang Xi-Jun and Yang Xing-Hua

Abstract

With the continuous increase of output power ratings, multi-phase (multichannel) interleaved power factor corrector (IPFC) is gradually employed in domestic and commercial inverter air-conditioners. IPFC can solve several main problems, such as power rating increase, power device selection, input current ripple reduction as well as inductor on-board mounting. But for a multi-phase IPFC, the key problem is that it should show rapid dynamic responds and good current sharing capability, so in this paper the aim is to improve the dynamic performance and current sharing capability by means of passivity control theory. Considering the power circuit topology of a four-phase IPFC, an EL (Euler-Lagrange) mathematical model is established when the IPFC operates in continuous conduction mode (CCM). Then the passivity of the four-phase IPFC is proved, and the passivity-based controller using the state variables feedback and damping injection method is designed. The proposed control scheme, which is easy to control and needs no proportion integral controller, has strong robustness on disturbance from singlephase AC input voltage, the load as well as the parameters of the employed devices. Even in wide-range load condition, the mains current has a fast dynamic response and the average output voltage almost keep unchanged. As a result, the main functions of the four-phase IPFC are implemented including nearly unitary power factor and constant DC output voltage. Meanwhile, the four-phase IPFC acquires an excellent current sharing effect after using passivity-based controller. The above analysis has been proved with simulated results by means of MATLAB/SIMULINK and experimental results, showing that the passivity-based IPFC controller has superior performances and feasibility.