Search Results

You are looking at 1 - 3 of 3 items for

  • Author: Jovan Lalošević x
Clear All Modify Search
Open access

Jovan Lalošević and Dušan Škiljević

Abstract

Sarcoidosis is a multisystem granulomatous disease and approximately one third of patients with the systemic form develop skin lesions. We present a case of cutaneous sarcoidosis associated with autoimmune thyroiditis and vitiligo. Although this association is rare by itself, it imposes the theory of autoimmune etiology of sarcoidosis. Moreover, our patient presented with elevated levels of serum chitotriosidase, a known biomarker in the activity of systemic sarcoidosis. To the best of our knowledge, there are no reports of chitotriosidase in isolated cutaneous sarcoidosis, raising a possible field for future research.

Open access

Jovan Lalošević, Branislav Lekić, Mirjana Gajić-Veljić, Dušan Škiljević, Katarina Đukić and Ljiljana Medenica

Abstract

Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC) is a subtype of VC, usually found on the sole of the foot.

Two patients, a 55-year-old female, and a 77-year-old male, with VC were treated at the Clinic of Dermatology and Venereology, Clinical Center of Serbia, from 2002 to 2011. Both patients presented with a tumor on the foot. Incisional biopsies showed a well differentiated squamous cell carcinoma. Foot x-rays showed bone involvement in one case. One patient underwent surgical amputation of the lower extremity, while the other had a partial amputation of the affected foot.

In the initial stage of the disease, it is difficult to distinguish pseudoepitheliomatous hyperplasia from verrucous carcinoma. The superficial biopsy of EC lesion may mislead to a histopathological diagnosis of warts or condylomas. Multiple deep biopsies are necessary for accurate and timely diagnosis of verrucous carcinoma.

Open access

Jovan Lalošević, Mirjana Gajić-Veljić, Jelena Stojković-Filipović, Martina Bosić and Miloš Nikolić

Abstract

Pachyonychia congenita (PC) is a rare inherited disorder of keratinization characterized by hypertrophic nail dystrophy, painful palmoplantar blisters, cysts, follicular hyperkeratosis and oral leukokeratosis. These pathological clinical features are resulting from mutations in keratin proteins including KRT6A, KRT6B, KRT6C, KRT16, and KRT17. We present a 6-year-old girl with hypertrophic nail dystrophy, follicular hyperkeratosis, circumscribed plantar keratoderma and oral leukokeratosis. The features were consistent with the diagnosis of PC. The patient has been registered in the International Pachyonychia Congenita Research Registry (IPCRR) and is waiting for a detailed genetic analysis. The IPCRR has contributed to publication of numerous papers which emphasized the importance of the mutation type affecting various clinical presentations of PC. Based on recent data, a new classification system has been developed for PC, and it is gradually replacing the earlier classifications. It is based almost exclusively on the mutated genes. In this report we have raised the hypothesis that distinctive clinical features may be highly suggestive of a specific keratin mutation.