Local economic environment is characterised by a range of economic, social, political and demographic parameters, based on which we can perform its analysis. Heterogeneity of relevant characteristics of the local economic environment imposes multiple criteria analysis as one of the suitable tools for the evaluation. Assessment of local economic environment often falls within the scope of group decision-making, as it is usually performed on the basis of an analysis of preferences of economic subjects or relevant experts on the issue of the economic environment at the local level. Regardless of whether it is based on economic subjects or expert group, in order to form a multi-criteria model, it is necessary to generate preferences of individuals into a single weight coefficient, which shows groups’ preference on the importance of each criterion. The subject of this paper is determination of weight coefficients in the multi-criteria model for the analysis of local economic development based on the preferences from a group of experts, by applying adequate statistical tools, and then by ranking local governments according to the quality of business environment perceived by the expert group.In addition to descriptive statistics and testing the significance of differences, in the paper is applied multi-criteria method Simple Additive Weights - SAW.
Measurement and evaluation of the bank’s operations efficiency requires analytical techniques that provide data beyond those available from the standard analysis of financial statements. The Data Envelopment Analysis (DEA) is a mathematical programming technique that offers valuable insights in finding inefficient banks taking into account the scope of the services and resources used to provide these banking services. The results of the DEA analysis can provide significant information to the bank’s management that can supplement the information obtained using traditional techniques for assessing efficiency. The assessment of banks’ efficiency in the Republic of Serbia is of particular importance due to intense competition and implemented banking reforms. Therefore, in this paper DEA analysis will be applied for the examination and assessment of the efficiency of the operations of Serbian banks during the period 2014-2016. The analysis will show which of the banks operates efficiently, where the efficiency of the banks is not at a satisfactory level, as well as the potential reasons for inefficiency.
Economic growth and competitiveness are usually analysed at the level of the national economy in traditional economic research. The problem of competitiveness within this line of thought is mainly regarded from the perspective of determining the sources of sustainable growth, which makes the economy more competitive than others. Competitiveness, therefore, is a multidimensional concept, which includes a range of factors, such as institutions, infrastructure, macroeconomic environment, market, human capital and technological development. Also, the process of joining the European Union significantly stimulates the development of the exact categories that are relevant for acceleration of the economic development. The aim of the paper is to assess the competitiveness of the candidate or potential candidate countries for membership in the European Union, through a comparative analysis of their competitiveness vis-à-vis EU countries. The results indicate that the competitiveness of the EU 15 countries, measured by Global Competitiveness Index and GDP per capita, is statistically significantly higher than the competitiveness of EU country group enlarged in the period 2004-2013, also compared to EU candidate or potential candidate countries. However, when it comes to the pillar of competitiveness related to the macroeconomic environment, according to the latest Global Competitiveness Report (2017-2018), the scores of the EU countries associated with enlargements in the period 2004-2013 are statistically significantly better than the EU 15 countries.
The topic of wealth and money distribution attracts great attention of economists, as well as researchers from other scientific fields, such as statistical physics and econophysics. An increasing number of models and simulations are being created in order to understand the process of wealth distribution and reaching the steady state of the distribution system. Also, the number of papers dealing with analysis and determining the distribution proportion is constantly growing, and, unlike the previous years, when the Pareto principle was “80-20”, today that principle could be “90-10”and even “90-20”. In this paper we present an agent-based simulation model derived from econophysics that describes the dynamics of wealth distribution. Two models of exponential function are tested: a one-phase model that uses the Newton’s law of cooling and a two-phase exponential function model. We found that exponential decreasing function adequately described the dynamics of wealth distribution, especially in the models without the possibility of borrowing money, and the validity of the Pareto principle “80-20” in these models could be confirmed.
Synchronous multiple carcinomas represent two or more primary carcinoma that occur sumultaneously in the same patient. In order to fulfill the condition that tumors are synchronous, each tumor must be primary and not a metastasis of another tumor. The occurrence of renal carcinoma synchronously with colonic carcinoma is not so common. On the other hand, the pathohistological image in rare cases shows a mixed glandular and neuroendocrine component described in earlier works. In this paper, we present a patient who made a colonoscopy, a biopsy from a tumor change in the cecum due to malady, fainting, loss of appetite, and a positive test for faecal occult bleeding, and confirmed that it is an adenocarcinoma of the cecum. Multi slise computerized tomography of the abdomen also described a tumor change in the uretero-pelocalrix system of the left kidney region. The patient had no urinary tract disorders. The diagnosis of the synchronous tumor of the cecum and left kidney was set. A right hemicolectomy with latero-lateral ileo-transverse anastomosis, as well as left nephroureterectomy, was performed. What is particularly interesting in this case is that the pathohistological picture of the cecum carcinoma shows a rare form of tumor tone, mixed adenoneuroendocrine carcinoma. In patients with diagnosed colorectal cancer, routine as well as additional preoperative diagnostic procedures should be performed to exclude the existence of kidney cancer, since, when synchronous with colorectal carcinoma occurs, renal carcinoma is mainly asymptomatic. In rare cases, the pathohistological picture may also show the neuroendocrine component of the tumor, which directs further therapy to the other direction.
The main purpose of this study was to isolate airborne fungi and assess seasonal variations in air contamination with their particulates by determining the levels of their propagules in the nave and exonarthex of a church. We also monitored indoor microclimate as a determining factor for fungal proliferation on wall paintings, spore release, and transmission through the air. The temperature and relative humidity of the nave favoured fungal growth. A total of 33 fungi were isolated, mainly of the phylum Ascomycota, and to the lesser extent of the phyla Zygomycota and Basidiomycota. The most common were the fungi of the genera Penicillium and Aspergillus (23.55 % and 20.58 %, respectively). Sørensen’s quotient of similarity (0.37) suggests moderate species overlap and constant exchange of fungal propagules between the nave and exonarthex. The autumn had the highest diversity, with 17 documented taxa, followed by the summer and the winter. The spring had only eight taxa. Quantitative analysis of the airborne mycobiota in the nave (430±84.85 to 1880±106.07 CFU m-3) and exonarthex (715±59.62 to 2295±91.92 CFU m-3) showed very high contamination throughout the year, with values exceeding the maximum permissible concentrations by most standards. Many of the fungi determined in this study are known for their biodeteriogenic, toxigenic, and allergenic properties, and are a threat not only to occasional visitors and staff, but also to valuable works of art decorating nave walls.
Response to glucocorticoid (GC) monotherapy in the initial phase of remission induction treatment in childhood acute lymphoblastic leukemia (ALL) represents important biomarker of prognosis and outcome. We aimed to study variants in several pharmacogenes (NR3C1, GSTs and ABCB1) that could contribute to improvement of GC response through personalization of GC therapy.
Retrospective study enrolling 122 ALL patients was carried out to analyze variants of NR3C1 (rs33389, rs33388 and rs6198), GSTT1 (null genotype), GSTM1 (null genotype), GSTP1 (rs1695 and rs1138272) and ABCB1 (rs1128503, rs2032582 and rs1045642) genes using PCR-based methodology. The marker of GC response was blast count per microliter of peripheral blood on treatment day 8. We carried out analysis in which cut-off value for GC response was 1000 (according to Berlin-Frankfurt-Munster [BFM] protocol), as well as 100 or 0 blasts per microliter.
Carriers of rare NR3C1 rs6198 GG genotype were more likely to have blast count over 1000, than the non-carriers (p = 0.030). NR3C1 CAA (rs33389-rs33388-rs6198) haplotype was associated with blast number below 1000 (p = 0.030). GSTP1 GC haplotype carriers were more likely to have blast number below 1000 (p = 0.036), below 100 (p = 0.028) and to be blast negative (p = 0.054), while GSTP1 GT haplotype and rs1138272 T allele carriers were more likely to be blasts positive (p = 0.034 and p = 0.024, respectively). ABCB1 CGT (rs1128503-rs2032582-rs1045642) haplotype carriers were more likely to be blast positive (p = 0.018).
Our results have shown that NR3C1 rs6198 variant and GSTP1 rs1695-rs1138272 haplotype are the most promising pharmacogenomic markers of GC response in ALL patients.