This article is a continuation of the same authors’ study entitled ‘Concepts And Delimitation Of The World’s Macro-Regions’ prepared for the 1/2018 of this journal (Anděl et al. 2018). The main aim of the first part was an evaluation of the concepts and factors which have been used as a basis for the delimitation of the different macro-regions of the world. In this second part, the authors propose their own macro-regionalisation of the world – this is a combination of four concepts, with relatively different contents: those of De Blij and Muller (1997), Cole (1996), Huntington (1996) and Hampl (2009). This macro-regionalisation arises from sociocultural affiliation, economic interrelationships and territorial continuity. Along with the concept of the macro-regional differentiation of the world itself, we focus on evaluating the importance of the shaping of macro-regions, as well as assessing the positive and negative features of individual concepts and their influence on the macro-regional differentiation of the world.