There is a lack of data about oral health-related quality of life (OHRQoL) among the parents of pre-school children, especially in Lithuania and the relationships among socio-economic status, oral care habits and OHRQoL. Research questions: is OHRQoL influenced by socioeconomic status or oral care habits? Research focus – oral health-related quality of life among the parents of pre-school children. The aim of this study was to analyze the relationships among socioeconomic status, oral care habits and oral helath-related quality of life among the parents of pre-school children in Klaipeda. The study sample consisted of 375 parents (mother or father) of pre-school children. The questionnaire survey was conducted at randomly selected 23 kindergartens in Klaipeda city. The questionnaire consisted of sociodemographic and oral care habits questions. All the participants were examined by self-administered OIDP questionnaire, which measured oral impacts on physical, psychological and social aspects of daily performances. The highest overall impact on OHRQoL among the parents of pre-school children was observed in the domain of Carrying out major work or role (73.0), the lowest one in the Eating and enjoying food (25.74) domain. Mean OIDP score was significantly higher among the parents whose socioeconomic status was low (35.44), reflecting poorer OHRQoL, as compared with high (8.07) socioeconomic status. Parents with poor oral care habits significantly more frequently were affected (79.2%) in Smiling, laughing domain, as compared to the parents whose oral care habits were good (20.8%). Lower socioeconomic status and poorer oral care habits were related with worsened oral health-related quality of life, especially in the area of psychological performances.