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Ana Irina Irimia

Abstract

We are currently in the process of making a Europe where the elements of national sovereignty will be narrowed through the sharing of sovereignty and for collective security. Another trend in the field was that of regionalization of the importance and implications of this issue, explicitly or implicitly considered as belonging to Central and Eastern Europe. Such an assessment neglects the significance of a number of factors pertaining to the historical and political developments has on the matter, particularly regarding economic development of Central and Eastern Europe areas, and that the conflictual degeneration of perceiving ethnical, cultural and regional otherness is not a phenomenon which affects this space alone, but also the West. In contradiction with this point of view, some foreign experts in the field say it is a social reality that discrimination and intolerance connected to religion and ethnicity can be found in all meetings of the world and in countries with different economic development phases.

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Irimia Irina, Ambrono Valentina and Stratu Anişoara

Abstract

This paper underlines some aspects regarding the anthropic influence on the “Movila lui Burcel” protected area. There were done some periodical displacement and observations in the field (2012-2014); there were identified anthropic factors with negative influence on the protected area; there were described the effects of the action of these factors. The anthropic factors with negative influence identified on the territory of the protected area are: the existence of the plantations of black locust (Robinia pseudoacacia) and Russian olive (Elaeagnus angustifolia); unreasonable grazing; presence of wastes and some fire hearths. The effects of the anthropic factors identified are represented by: modifications of the habitat with serious consequences on the existence and perpetuation of rare and vulnerable species included on the red lists; degrading of landscape.

Open access

Ruxandra Irimia, Ioana Teodora Tofolean, Roxana Gabriela Sandu, Oana Elena Băran, Maria Cătălina Ceauşescu, Vlad Coşoreanu, Maria Teodora Ilie, Ramona Babeş, Constanţa Ganea and Irina Băran

Abstract

Doxorubicin is a widely used chemotherapeutic drug, effective on patients with acute lymphoblastic leukemia but associated with significant long term cardio-toxicity. Menadione (vitamine K3) and the flavonoid quercetin are known as strong apoptogens in human leukemia Jurkat T cells.

We explored the potential synergic cytotoxic effects of doxorubicin in association with quercetin and Menadione in this cellular model for acute lymphoblastic leukemia.

Cellular viability, apoptosis, necrosis oxidative stress and cellular cycle were determined by flow cytometry utilizing Jurkat lymphoblasts labeled with Annexin V-FITC/7-AAD, CM-H2DCFDA/7-AAD and propidium iodide respectively.

Results indicate a dose-dependent oxidative-stress generation, cell cycle arrest and apoptosis induction by doxorubicin alone, correlated with a decrease of the required doses when the anticancer drug was associated with quercetin and menadione, hence supporting the theory of an additive cytotoxic effect on leukemia cells.

Introducing QC-MD combinations in leukemia doxorubicin-based treatment could significantly increase the treatment’s efficacy. The main mechanism responsible for this effect appears to be the increase in DOX affinity for DNA, which enables lowering of the therapeutic dose.