Search Results

You are looking at 1 - 1 of 1 items for

  • Author: Ik Soon Jang x
Clear All Modify Search
Open access

Dong-Gi Lee, Ik Soon Jang, Kyeong Eun Yang, So-Jung Yoon, Sujeong Baek, Joo Yong Lee, Tatsuro Suzuki, Keun-Yook Chung, Sun-Hee Woo and Jong-Soon Choi


This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.