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Open access

Davood Hashemabadi, Fatemeh Sabzevari, Behzad Kaviani and Mohammad Hossein Ansari


The aim of the study was to replace mineral fertilizers with organic and biological fertilizers to improve nutrient uptake, plant growth and the concentrations of some important secondary metabolites in periwinkle (Catharanthus roseus L.). Periwinkle plants were grown under different rates of N supply (0, 20 and 40 mg kg−1 soil) and biological treatments (Azospirillum, Azotobacter, Azospirillum plus Azotobacter, Azospirillum plus fungal compost, Azotobacter plus fungal compost, and fungal compost). The concentrations of pigments and nutrients were measured by spectrophotometry and flame photometry. Secondary metabolites were analyzed by high-performance liquid chromatography (HPLC). Data were recorded for plant growth and development parameters, nutrient uptake and some secondary metabolites of periwinkle plants. The results showed that the N-fertilizer and biological treatments significantly improved most growth attributes and nutrient uptake and increased the concentrations of secondary metabolites as compared to the control. Maximum concentrations of root ajmalicine (0.54 mg g−1 DW), leaf vinblastine (0.96 mg g−1 DW) and root catharanthine (2.38 mg g−1 DW) were obtained from the treatment with Azospirillum under N-fertilizer at 20 and 40 mg kg−1 soil. Azotobacter along with fungal compost under N-fertilizer at 40 mg kg−1 soil induced the maximum concentration of leaf vindoline (1.94 mg g−1 DW). The highest concentration of root alkaloids (1.11 mg g−1 DW) was obtained from the treatment with compost under 40 mg N kg−1 soil. Azospirillum, Azotobacter and fungal compost combined with the N-fertilizer improved many morphological and nutrient characteristics. In conclusion, the growth and metabolism of C. roseus were significantly positively affected by the organic and biological fertilizers.

Open access

Sanaz Faramarz-Gaznagh, Yousef Rasmi, Mohammad-Hasan Khadem-Ansari, Mir-Hossein Seyed-Mohammadzad, Morteza Bagheri, Mohadeseh Nemati, Alireza Shirpoor and Ehsan Saboori


Background: Slow coronary flow (SCF) is a coronary artery disorder characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. The pathophysiological mechanisms of SCF remain un clear. One of the possible mechanisms that may participate in the pathology of SCF is endothelial dysfunction related to the inflammatory process. Interferon gamma (IFN-γ) is an inflammatory cytokine that acts through its specific receptor composed of two subunits, IFN-γR1 and IFN-γR2. Trans criptional activity of the gene encoding these subunits influences IFN-γ activity. This study aimed to investigate the gene expression of IFN-γ receptor subunits in peripheral blood mononuclear cells (PBMC) from patients with SCF.

Methods: The study was performed with 30 patients (22 male/8 female) aged 35–76 (52.8±11.7 years) with SCF and 15 sex-(11 male/4 female), Body Max Index (BMI)-and age-matched (54.73±9.42 years) healthy subjects. Total mRNA was extracted from PBMC and was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). The relative expression values (2−ΔΔCt) between control and case groups were determined and the Mann-Whitney U test was used for statistical analysis.

Results: There was a significant increase in the gene expression of IFN-γR1 in PBMC from SCF patients vs. controls (P< 0.0001); but the differences in IFN-γR2 gene expression were statistically insignificant between patient and control groups (P= 0.853).

Conclusions: It can be concluded that IFN-γR1 gene expression may influence the function of microvasculature and thereby contribute to the pathophysiology of SCF.

Open access

Parisa Shabibi, Peiman Shabibi, Mostafa Qorbani, Babak Rastegarimehr, Omid Safari, Zahra Shafieyan, Hamid Asayesh, Hossein Ansari, Mohammad Sadegh Abedzadeh Zavareh and Morteza Mansourian


Background and aims: Diabetes is considered as the most prevalent disease due to metabolic disorders. This study aimed to determine the effect of an educational on the quality of life) QOL( in patients with type 2 diabetes mellitus (T2DM ). Material and methods: This quasi-experimental study was conducted in the form of a pre-test/post-test with intervention. The statistical sample of this study included 70 patients with type 2 diabetes living in the rural areas in the city of Ilam (west of Iran). The data were analyzed using the SPSS software version 20 via descriptive statistics, paired t-student test, independent samples t-student test, and ANOVA. Results: Except social role functioning, all aspects of QOL significantly increased after intervention (p<0.001). Regardless of age groups, gender, and educational level the QOL scores increased at follow -up (p<0.001). Conclusions: Education to patients with type 2 diabetes leads to increased means of all dimensions of QOL that reflect the effects of educational interventions on each domain.