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Bin Xu and Wangli He

Abstract

This paper is concerned with cluster consensus of linear multi-agent systems via a distributed event-triggered control scheme. Assume that agents can be split into several clusters and a leader is associated with each cluster. Sufficient conditions are derived to guarantee the realization of cluster consensus by a feasible event-triggered controller if the network topology of each cluster has a directed spanning tree and the couplings within each cluster are sufficiently strong. Further, positive inner-event time intervals are ensured for the proposed event-triggered strategy to avoid Zeno behaviors. Finally, a numerical example is given to illustrate the effectiveness of the theoretical results.

Open access

Gou Zhenzhi, He Bin and Yang Guilin

Abstract

Because the heat release of plutonium material, the composite structure is heated and the stress and strain of the composite structure will increase, which will affect the thermodynamic properties of the structure. The thermodynamic analysis of complex structures, which are composed of concentric structures of plutonium, beryllium, tungsten, explosives, and steel, was carried out. The results showed that when the structure is spherical, the temperature is higher than that of the ellipsoid structure. Stress of the elliptical structure is greater than the spherical structure. This study showed that the more flat the shell is, the greater the stress concentration point occurs at the long axis, and the maximum stress occurs at the beryllium layer. These conclusions provide theoretical support for the plutonium composite component testing.

Open access

Wen Xie, Hong Zhao, Yu Chen, Qin Zhang, Wei Lu, Wei Liu, Ai-rong Hu, Han-wei Li, Ping Feng, Ming-sheng Chen, Cun-jin Mei, Xiao-lin Guo, Xiao-hu Zhao, Jiang-bin Wang, Zheng-qin Fan, Jian-he Gan, Qing Xie and Jun Cheng

Abstract

Obejective Ademetionine 1,4-butanedisulfonate [S-adenosyl-L-methionine (SAMe)/Transmetil®, Abbott] has been available in China for more than 15 years, and it has been shown to reduce serum bilirubin and transaminase levels in viral hepatitis (VH) patients. However, no large-scale studies have focused on the impact of SAMe treatment regimen on reducing the serum total bilirubin (TBil) in VH patients with intrahepatic cholestasis (IHC). The primary purpose of this study was to evaluate the effectiveness of intravenous SAMe (Transmetil®) treatment in reducing the serum TBil by 50%.

Methods This retrospective, multi-center, cross-sectional medical record review involved patients aged ≥18 years. Records of 1 280 hospitalized VH patients at 16 sites diagnosed with IHC who had received intravenous SAMe 1 000 mg or 2 000 mg q.d. for at least 7 days from January 1, 2006 to June 30, 2009, were screened and 905 records were randomly selected.

Results The safety set (SS) included 834 patients and the full analysis set 826 patients. TBil levels after 14 days injection treatment were available for 763 patients. TBil decreased ≥ 50% versus baseline after 14 days treatment in 288 (37.7%) patients (95% CI 34.3%, 41.2%). Twenty-nine non-serious adverse events (non-SAEs) were reported in 19 (2.3%) patients, and 29 SAEs were reported in 10 patients (1.2%). All adverse events (AEs) were considered unrelated to the study drug.

Conclusions This retrospective study shows that intravenous SAMe administration in VH patients with IHC is associated with significant reduction of TBil levels in more than 30% of patients 14 days after treatment initiation.