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Open access

Hao-feng Xiong, Jing-yuan Liu, Hao-dong Cai and Jun Cheng

Abstract

Acute pancreatitis in pregnancy (APIP) is rare and the reasons for APIP are biliary disease and congenital or acquired hypertriglyceridemia, which could occur during any trimester but more than 50% cases happened during the third trimester. In this report, one case of a young pregnant woman, a HBV carrier in her 37th week + 5 d of gestation, was admitted to Emergency Department due to acute abdominal pain, vomiting and diarrhea. The patient was in antiretroviral treatment with telbivudine from 28 weeks of gestation to prevent motherto- child transmission of HBV. Laboratory tests demonstrated hypertriglyceridemia, abdominal computed tomography scan revealed peripancreatic edema. Hyperlipidemic pancreatitits was primary diagnosed and the patient was admitted to the intensive care unit. Considering the possible role in the pathogenesis of pancreatitis, telbivudine was interrupted after birth giving. After supportive treatment, her condition gradually improved. Since it is the first description of APIP during treatment with telbivudine, the association between pregnancy, hyperlipidemia, telbivudine and acute pancreatitis has been well investigated.

Open access

Si Chen, Hai-ru Long, Ying-hao Liu and Feng-chao Hu

Abstract

In this paper, the mechanical properties (compression and impact behaviours) of three-dimension structure (3D-structure) composites based on warp-knitted spacer fabrics have been thoroughly investigated. In order to discuss the effect of fabric structural parameters on the mechanical performance of composites, six different types of warp-knitted spacer fabrics having different structural parameters (such as outer layer structure, diameter of spacer yarn, spacer yarn inclination angle and thickness) were involved for comparison study. The 3D-structure composites were fabricated based on a flexible polyurethane foam. The produced composites were characterised for compression and impact properties. The findings obtained indicate that the fabric structural parameters have strong influence on the compression and impact responses of 3D-structure composites. Additionally, the impact test carried out on the 3D-structure composites shows that the impact loads do not affect the integrity of composite structure. All the results reveal that the product exhibits promising mechanical performance and its service life can be sustained.

Open access

Li H. Wang, Hao Liu and Li Li

Abstract

A carbon-based solid acid catalyst was prepared by the sulfonation of carbonized seed shells of Jatropha curcas (J. curcas L.). The structure of amorphous carbon consisting of polycyclic aromatic carbon sheets attached a high density of acidic SO3H groups (2.0 mmol · g−1) was identified with scanning electron microscopy (SEM), fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The performance of the solid acid catalyst was evaluated for biodiesel production in the esterification of oleic acid with methanol. 95.7% yield of biodiesel was obtained after 2 h reaction and the conversions with reused catalyst varied in the range of 95.7% to 95.1%, showing better activity and stability than commercial catalyst amberlyst-46. It was also observed that the prepared catalyst showed enhanced activity in the transesterification of triolein with methanol when compared with other solid acid catalysts. A synergistic effect results from the high density of SO3H groups and the good access of reactants to the acidic sites can be used to explain the excellent catalytic activity, as well as the strong affinity between the hydrophilic reactants and the neutral OH groups bonded to the polycyclic aromatic carbon rings.

Open access

Hao Wang, Fei Zhao, Yuan-Sheng Cheng, Jun Liu and Yuan Tian

ABSTRACT

The fluid-solid interaction (FSI) dynamic responses for a Light Weight Pyramidal Sandwich Plate Structure (LWPSPS) under different water-entry velocities (1m/s-6m/s) are investigated numerically and theoretically. The characteristics of impact pressure and structure deformation are obtained by using LS-DYNA code based on the proposed 3D multi-physics (air-water-solid) FEM model. Numerical results show that the average water impact pressure of LWPSPS is much lower than that of the monolithic plate with same mass. Moreover, a phenomenon called “local air cushion” is observed for LWPSPS which does not exist for a monolithic plate. Theoretical hydroelasticity analysis demonstrates that the FSI effect of LWPSPS is weak when the ratio of water impact duration time to wet natural vibration period is greater than 4. In the study, an engineering estimation method to predict the maximum deformation of the LWPSPS is proposed, in which the total deformation is divided into two parts, i.e. local field deformation and global field deformation, and they are both computed using analytical model. Good agreement between the numerical results and ones obtained from the proposed engineering estimation method is achieved. Furthermore, the geometric variation sensitiveness analysis is also conducted.

Open access

Wang Zhen-fei, Liu Li, Liang Lin and Hao Qin

Abstract

Objective

The aim of this study was to investigate the effect of Radix Glehniae on the migration and invasion abilities of lung cancer cells.

Methods

Normal bronchial cell line 16HBE and lung cancer cell line SK-MES-1 were treated with Radix Glehniae extract. Proliferation, migration, and invasion abilities were determined by Cell Counting Kit (CCK)-8, Transwell, and Matrigel assays, respectively. The expression and secretion levels of tissue inhibitor of metalloproteinases 2 were detected by quantitative PCR and enzyme-linked immunosorbent assay, respectively.

Results

Radix Glehniae extract inhibited the migration and invasion abilities of SK-MES-1 cells and enhanced TIMP2 expression and secretion by SK-MES-1 cells, without causing toxicity to 16HBE cells.

Conclusion

Radix Glehniae is useful in lung cancer treatment.

Open access

Sirui Yang, Weihong Xu, Shibo Li, Shicheng Liu, Honghua Lu, Xiaosheng Hao, Feiyong Jia and Guiling Xue

Abstract

Background: Hereditary ataxia is a group of hereditary diseases that are characterized by chronic progressive uncoordinated gait and are frequently associated with cerebellar atrophy.

Objectives: To investigate evidence-based diagnosis of hereditary ataxia by retrospective analysis of the diagnostic process in one Chinese family.

Methods: Clinical records of 15 ataxia patients from one Chinese family with 46 family members were retrospectively reviewed and a tentative diagnosis was made based on clinical manifestations, signs and symptoms, mode of inheritance, and progression. Since hereditary ataxia is a group of heterogeneous diseases having various subtypes and overlapping symptoms, we adopted a stepwise evaluation to achieve a tentative diagnosis. To confirm the diagnosis, we performed polymerase chain reaction (PCR) specific for the suspected causative gene of spinocerebellar ataxia (SCA) subtype 3 (SCA3).

Results: Through analysis of hereditary and clinical characteristics of family histories of the patients, we suspected that the family might suffer from SCA, especially, SCA3. The PCR assay for SCA3 showed that, five of the ten samples analyzed had a CAG trinucleotide expansion of the SCA3 gene, and four of the five members developed ataxia. The remaining one, a seven-year-old girl, showed no symptoms or signs except for uvula deviation. No clinical symptoms were found in five other members with negative PCR results. Thus, based on both clinical findings and laboratory results, we further confirmed that the family suffered from SCA3.

Conclusion: Hereditary ataxias are disorders sharing overlapping symptoms. Comprehensive analysis of medical and family records together with genetic diagnosis improves diagnostic efficiency of hereditary ataxia and aides in family counseling.

Open access

Hao Luo, Tingting Liu, Jun Ma, Wei Wang, Heng Li, Pengwei Wang, Jintao Bai and Guangyin Jing

Abstract

The morphology of nanospheres is crucial for designing the nanofabrication in the nanosphere lithography. Here, by plasma etching, the controllable tailoring of the nanosphere is realized and its morphology dependence on the initial shape, microscopic roughness, and the etching conditions is investigated quantitatively. The results show that the shape evolution strongly depends on the etching gas, power, and process duration. Particularly, the aspect ratio (diameter/height) significantly increases with violent etching, turning the spherical shape into tiny ellipsoidal nanoparticles. The findings are practical to the protocol of non-uniform etching of nanoobjects and provide the useful design tool for the device fabrication at nanoscale.

Open access

Yu Qiao, Xiao-Ming Feng, Ze-Zhou Liu, Shuang-Shuang Wang, Yu-Jin Hao and Chun-Xiang You

Cloning and Expression Analysis of LeTIR1 in Tomato

The full-length cDNA of LeTIR1 gene was isolated from tomato with EST-based in silico cloning followed by RACE amplification. LeTIR1 contained an open reading frame (ORF) 1872 bp long, encoding 624 amino acid residues. The predicted protein LeTIR1 had one F-box motif and eleven leucine-rich repeats (LRRs), all of which are highly conserved in TIR1 proteins of other plant species. Phylogenetic analysis showed that the LeTIR1 protein shared high similarity with other known TIR1 proteins. Both sequence and phylogenetic analysis suggested that LeTIR1 is a TIR1 homologue and encodes an F-box protein in tomato. Semi-quantitative RT-PCR indicated that LeTIR1 was expressed constitutively in all organs tested, with higher expression in stem than root, leaf, flower and fruit. Its expression level was positively correlated with the auxin distribution in stem or axillary shoot, and was induced by spraying exogenous IAA.

Open access

Wen Chao Liu, Mao Ye, Jia Hao Liao, Zhi Hui Zhao, In Ho Kim and Li Long An

Abstract

The use of probiotics as alternatives to antibiotics for farm animals is gaining more and more interest during recent years. Probiotics are living microorganisms that provide a wide variety of health benefits to the host when ingested in adequate amounts. The bacterial strains most frequently used as probiotic agents are Bacillus, lactic acid bacteria, Enterococcus and Saccharomyces cerevisiae. It has been suggested that multi-strain probiotics might be more effective than mono-strain probiotics due to the additive and synergistic effects, and many previous studies demonstrated that dietary complex probiotics supplementation had growth promoting effects on pigs. However, the effect of complex probiotics in practice is not always consistent, the effect of probiotic could be affected by strain composition, dosage, feed formula, and the age of animals. In this review, we will give an overview on the current use of complex probiotics for weaning, growing and finishing pigs and sows.