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L. Gurgas, N. D. Popescu, L. T. Hangan, S. Chirila and Natalia Rosoiu

Abstract

The paper proposes new exposure data on etiopathogenesis basal cell epithelioma and present a clinical case investigated dermatoscopic, biochemically, treated surgically and guided to avoid relapses. The case presented is part of typical cases of pigmented basal cell carcinoma. Biochemical and haematological investigations performed one day before the excisional intervention (results 1) and 30 days (results 2) after the intervention: It is recommended to monitor biochemical investigations in which alterations were found, and ways for raising the immunological status.

Open access

Ionescu Ana-Maria, Dumitrescu Cătălin, Copaci Carmen, Iliescu Dan, Hangan Tony and Bobe Alexandru

Abstract

Electroencephalogram (EEG) analysis consists of locating signal structtures in time and frequency. A detection method based on the Matching Pursuit Algorithms finds the suboptimal solution of the function optimal linear expansion over a redundant waveform dictionary. This paper has put forth a method for the automatic detection and analysis of transient waves during sleep based on the matching pursuit method with a real dictionary og Gabor functions. Each wave peak is described in terms of natural parameters. In this context, there have been confirmed several literature hypotheses regarding the spatial, temporal, and frequency distribution of transient waves during sleep, and their relationships with slow wave brain activity. Mastery and expertise in clinical EEG interpretation is one of the most desirable disgnostic clinical skills in interpreting seizures, epilepsy, sleep disorder, biomarkers for early disgnosis of Parkinson’s and Alzheimer’s disease, and other neurocognitive studies.

Open access

Dumitrescu Cătălin, Copaci Carmen, Iliescu Dan, Hangan Tony, Ionescu Ana-Maria and Bobe Alexandru

Abstract

The wide variety of waveform in EEG signals and the high non-stationary nature of many of them is one of the main difficulties to develop automatic detection system for them. In sleep stage classification a relevant transient wave is the K-complex. This paper comprehend the developing of two algorithms in order to achieve an automatic K-complex detection from EEG raw data. These algorithms are based on a time-frequency analysis and two time-frequency techniques, the Short Time Fourier Transform (STFT) and the Continuous Wavelet Transform (CWT), are tested in order to find out which one is the best for our purpose, being of two wavelet functions to measure the capability of them to detect K-complex and to choose one to be employed in the algorithms. The first algorithm is based on the energy distribution of the CWT detecting the spectral component of the K-complex. The second algorithm is focused on the morphology of the K-complex / sleep spindle waveform after the CWT. Evaluating the algorithms results reveals that a false K-complex detection is as important as real K-complex detection.

Open access

Mirela-Simona Nicodim, Mariana Aşchie, Doina Catrinoiu and Laurenţiu-Tony Hangan

Abstract

Background and Aims. Patients with diabetes mellitus, especially type 2 diabetes, have often a multifactorial renal impairment. The aim of this study was to correlate renal vascular lesions occurring in patients with diabetes mellitus with clinical and laboratory parameters. Material and method. We performed a retrospective study on a sample of 127 patients with diabetes mellitus, who died in hospital. Data from necropsies were correlated with the clinical and laboratory data collected from the medical records of these patients. Results. Renal vascular lesions were frequently found in patients from the study group. The most common were nephroangiosclerosis lesions, which correlated with age, diabetes duration, systolic blood pressure and mean fasting glucose. Conclusions. Most patients in the study group had multiple cardiovascular risk factors (advanced age, dyslipidemia, hypertension) that explain the high prevalence of renal vascular lesions.

Open access

Gurgas Leonard, Rosoiu Natalia, Chirila Sergiu and Hangan Tony

Abstract

In recent years, numerous scientific research papers have focused on the analysis of immunological, biochemical, ultrastructural, molecular and genetic factors that govern the clinical aspects of basal cell carcinomas. This retrospective study was carried out in the Clinical Department of Dermatovenerology at the County Emergency Clinical Hospital “Sf. Apostol Andrei”, Constanta. The research included a total of 140 patients treated in the clinic, with a diagnosis of basal cell epithelioma. We analyzed several biochemical and hematological markers including creatinine, male HDL cholesterol, female HDL cholesterol, LDL cholesterol, urea, serum glucose. More than half of patients with BCC present data of possible hepatic impairment and high atherogenic risk.

Open access

Gurgas Leonard, Doru-Popescu Nelu, Hangan Tony, Chirila Sergiu, Moroianu Olimpia and Roşoiu Natalia

Abstract

The electron microscopic study represent the changes in the skin layers in the malignant tumor, the nodular basal cell epithelioma. Comparisons were made between normal cells found in the normal skin at the periphery of the tumor, the cells located near the tumor and the tumors located in the depth of the carcinoma. The microscopic analysis of the tumor formation revealed the characteristics of the pigmented nodular basal cell epitheliu. To the exterior of the carcinoma were evidenced numerous globular formations limiting the peripheral extension of the tumor, which explains its evolution in years.