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Open access

Mansur Rahnama, Michal Lobacz, Anna Szyszkowska, Grzegorz Trybek and Maryla Kozicka-Czupkallo

Abstract

In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups.

Open access

Bożena Mroczek, Małgorzata Anna Lichota, Grzegorz Trybek and Anna Grzywacz

Summary

Background/Aim: The loss of teeth and its consequences for health, as well as the psychological discomfort it entails, have a negative impact on both self-reported health state and quality of life (QoL). Dental implantation aims to increase patients’ health and satisfaction and to improve all aspects of QoL. The purpose of this cross-sectional correlational study was to compare the patients’ QoL before and after dental implantation.

Material and Methods: The study comprised 62 patients aged between 24 and 77, including 28 (45.16%) women and 34 (54.84%) men, who reported to a private dental clinic in Szczecin, Poland to replace missing teeth with implants. The survey was carried out twice: prior to the treatment, when the decision to use implants had been made, and three months after implantation, during the first check-up. QoL was measured using the 36-Item Short Form Health Survey (SF-36), and sociodemographic data were collected using a questionnaire of the author.

Results: There were statistically significant differences between the assessment of health and QoL before and after implantation treatment. Both the patients’ health and comfort of life improved after therapy.

Conclusions: Replacement of missing teeth with dental implants brought overall improvement in patients’ QoL, social comfort, and general health. Dental implantation should be recommended in the early phase of edentulism, after tooth loss.

Open access

Paweł Cięszczyk, Agata Leońska-Duniec, Agnieszka Maciejewska-Skrendo, Marek Sawczuk, Katarzyna Leźnicka, Valentina Contrò, Grzegorz Trybek and Ewelina Lulińska-Kuklik

Abstract

Purpose. A common polymorphism in the angiotensin converting enzyme I gene (the ACE I/D variant) represents one of the first characterized and the most widely studied genetic variants in the context of elite athletes status and performance related traits. The aim of the study was to determine the genotype and allele distribution of the allele and genotype of the ACE gene in Polish male football players. Methods. The total of 106 Polish male professional football players were recruited. They were divided into groups according to the position in the field: forwards, defenders, midfielders, and goalkeepers. For controls, samples were prepared with 115 unrelated volunteers. DNA was extracted from the buccal cells donated by the subjects, and the PCR amplification of the polymorphic region of the ACE gene containing either the insertion (I) or deletion (D) fragment was performed. Results. The genotype distribution and allele frequencies among all football players did not differ significantly when compared with sedentary control individuals (p = 0.887, p = 0.999, respectively). Likewise, the analysis of forwards, defenders, midfielders, and goalkeepers revealed no significant differences in either ACE genotype or allele frequencies. Conclusions. We did not provide evidence for difference of variation of the ACE I/D polymorphism between Polish football players and controls, as we did not obtain any statistically significantly higher frequency of either of the analysed alleles (I and D) or genotypes (DD, ID, and II) in the studied subgroups. It may be suspected that harbouring of I/D allelic variants of the ACE gene neither decreases nor increases the probability of being a professional football player in Poland.

Open access

Paweł Cięszczyk, Aleksandra Zarębska, Zbigniew Jastrzębski, Michał Sawczyn, Izabela Kozakiewicz-Drobnik, Agata Leońska-Duniec, Mariusz Kaczmarczyk, Agnieszka Maciejewska-Skrendo, Piotr Żmijewski, Grzegorz Trybek, Wojciech Smółka, Jan Pilch, Katarzyna Leźnicka, Ewelina Lulińska-Kuklik, Marek Sawczuk and Myosotis Massidda

Abstract

The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphic variant is a candidate to explain the individual differences in trainability and response to exercise training. Therefore, the aim of the study was to verify whether the A1298C polymorphism influenced the aerobic and anaerobic performance as well as body and mass composition in young Polish women following low-high impact aerobic exercise training. Two hundred and one women aged 21 ± 1 years (range 19–24) were included in the study. All of them completed a 12-week exercise training program and were measured for selected somatic features, aerobic capacity and cardiorespiratory fitness indices as well as peak anaerobic power and anaerobic capacity, before and after the intervention. A mixed 2 x 2 ANOVA for 20 dependent variables grouped in three categories was conducted. No significant interaction of the genotype with training for body mass and body composition variables was observed. Although, there were three significant genotype x training interactions for maximal oxygen uptake variables, regardless of body mass i.e.: for VO2max (p < 0.05), HRmax (p < 0.0001) and HRAT/HRmax (p < 0.0001). Significantly greater improvement in VO2max was gained by the CC+AC group compared to the AA genotype group. The present results support the hypothesis that individual differences in trainability are at least in part determined by the genetic component and MTHFR A1298C seems to be one of the many polymorphisms involved.

Open access

Wojciech Krzemień, Mateusz Bała, Tomasz Bednarski, Piotr Białas, Eryk Czerwiński, Aleksander Gajos, Marek Gorgol, Bożena Jasińska, Daria Kamińska, Łukasz Kapłon, Grzegorz Korcyl, Paweł Kowalski, Tomasz Kozik, Ewelina Kubicz, Szymon Niedźwiecki, Marek Pałka, Lech Raczyński, Zbigniew Rudy, Oleksandr Rundel, Neha Gupta Sharma, Michał Silarski, Artur Słomski, Karol Stola, Adam Strzelecki, Damian Trybek, Anna Wieczorek, Wojciech Wiślicki, Marcin Zieliński, Bożena Zgardzińska and Paweł Moskal

Abstract

The Jagiellonian Positron Emission Tomograph (J-PET) collaboration is developing a prototype time of flight (TOF)-positron emission tomograph (PET) detector based on long polymer scintillators. This novel approach exploits the excellent time properties of the plastic scintillators, which permit very precise time measurements. The very fast field programmable gate array (FPGA)-based front-end electronics and the data acquisition system, as well as low- and high-level reconstruction algorithms were specially developed to be used with the J-PET scanner. The TOF-PET data processing and reconstruction are time and resource demanding operations, especially in the case of a large acceptance detector that works in triggerless data acquisition mode. In this article, we discuss the parallel computing methods applied to optimize the data processing for the J-PET detector. We begin with general concepts of parallel computing and then we discuss several applications of those techniques in the J-PET data processing.