Search Results

You are looking at 1 - 4 of 4 items for

  • Author: Gergana N. Sandeva x
Clear All Modify Search
Open access

Pavlina L. Gidikova, Gergana N. Sandeva, Kamelia H. Haracherova and Rositsa V. Sandeva

Summary

A person's weight depends on major factors like genetics, diet, and physical activity. Physical activity in adults is defined mainly by workload – light, moderate or heavy. The aim was to explore associations between weight and chronic non-infectious diseases in workers with different physical activity. The subjects included in the study were 224 male and 249 female employees, divided by workload based on their job description. Body mass index (BMI) and disease incidence were calculated, and statistical analysis was performed. The highest percentage of overweight and obese subjects was found in men with light workload. The mean BMI for men (27.434.85) was significantly higher than that for women (25.875.06). Analysis of obesity-associated diseases showed that in workers with higher BMI there was a higher incidence of endocrine disorders, musculoskeletal and related neurological diseases. Diseases of the circulatory system were highly prevalent in both overweight/obese and underweight employees. In conclusion, physical activity at work contributes to changes in BMI in the working population. Obesity-associated circulatory, endocrine and musculoskeletal diseases were highly prevalent in the groups with higher BMI. The prevalence in employees without diseases was in inverse relation to BMI.

Open access

Gergana N. Sandeva, Rositsa P. Deliradeva and Pavlina L. Gidikova

Summary

Assessment of work ability is an important aspect of occupational medical services, the main goal being to maintain employees’ health, well-being and efficiency. The aim of the study was to evaluate and compare the work ability of workers employed by two machinery factories. We used the Work Ability Index (WAI) questionnaire to assess 165 workers of an iron casting factory A and 166 workers in a press-forging plant B. The data obtained were evaluated and compared based on gender, age, length of service and occupation. Mean WAI for the two factories were almost identical (43.3±4.9 for Factory A and 43.3±4.6 for Factory B), both indicating good overall work ability. The lowest mean WAI (37.7) was registered for the crane operators from Factory B, and the highest (47.2) - for the molders in Factory A. The female production workers in Factory A had a significantly lower WAI as compared to their male counterparts (p=0.001). WAI also varied significantly between different age groups and occupations in the two plants. Significant negative correlations were found between work ability and length of service, as well as between psychological resources and gender (Factory A) and the length of service (Factory B). WAI is a useful tool in finding vulnerable workers who need more attention from occupational health specialists.

Open access

Rositsa V. Sandeva, Stanislava M. Mihaylova and Gergana N. Sandeva

Summary

The participation of the anorexigenic peptide leptin and the orexigenic peptide ghrelin in the pathogenesis of metabolic syndrome and obesity is well studied. In this review, we are taking a look at the structure, anatomical expression, regulation, receptors and physiological functions of these two neuropeptides. Leptin is produced almost exclusively in adipose tissue. It acts on the brain and is a key element in long-term regulation of energy balance. Leptin suppresses appetite and reduces body weight. Besides its central effects, important aspects of its action on peripheral tissues have been discovered recently: direct regulation of immune cells, pancreatic beta cells, adipocytes and muscle cells. Ghrelin is an endogenous ligand for the active form of the growth hormone receptor (GHS-R1a) and stimulates food intake and growth hormone secretion. We focus on the role of leptin and ghrelin in central nervous system neural mechanisms that are associated with depression. Studying new aspects of these two neuropeptides aims to expand our knowledge of the pathogenesis and therapeutic approaches to diseases with which they are associated: obesity, depression, type 2 diabetes, essential hypertension, and more.

Open access

Rositsa V. Sandeva, Stanislava M. Mihaylova, Gergana N. Sandeva, Katya Y. Trifonova and Ruska D. Popova-Katsarova

Summary

In Europe, as well as in Bulgaria, consumption of soft drinks and confectionery has increased during the last three decades and is partly responsible for the epidemic-like increase in obesity. These foods, originally sweetened by sucrose, are now sweetened by other caloric sweeteners such as fructose. In this study we investigated the effect of an eight-week intake of 20% fructose solution on body weight in rats. Two adult rat groups (aged 120±6 days) of Wistar line were studied: a Control group (C; n=10; 5 male and 5 female rats) received water and standard rodent chow, and a Fructose group (F; n=12; 6 male and 6 female rats) who received 20% fructose-in-drinking-water solution and regular rodent chow. All animals were weighed and measured (nose to anus length), and the Lee index (equivalent of BMI in rats) was calculated. Body fat was also analyzed. As indicators of increased caloric intake of the Fructose group we investigated glucose, triglycerides and cholesterol (total, HDL and LDL) in blood. In conclusion, consumption of fructose solution in rats resulted in increased body weight, length and measured body fat, increased blood glucose, total cholesterol and triglycerides in the Fructose group, as compared to the controls.