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M. Adamek, G. Rauch, G. Brogden and D. Steinhagen

Abstract

A Cyprinid herpesvirus 3 infection of carp induces a disease which causes substantial losses in carp culture. Here we present the use of a possible strategy for the management of the virus infection RNA interference based on small interfering RNAs. As a result of in vitro studies, we found that a mixture of short interfering RNAs specific for viral DNA enzyme synthesis and capsid proteins of the CyHV-3 can be a potential inhibitor of virus replication in fibroblastic cells. This gives the basis for the development of a combinatorial RNA interference strategy to treat CyHV-3 infections.

Open access

G. Adamek, J. Jakubowicz and M. Dewidar

Abstract

The paper presents the preparation of Ti-(1-30wt.%)Y2O3 composites using the mechanical alloying process. Ti based materials are the best metallic biomaterials because of their excellent properties: biocompatibility, low Young moduli and high corrosion resistance. Pure Ti and Y2O3 powders were alloyed under argon atmosphere in shaker type mill (Spex 8000) followed by pressing and sintering.

The ultra-low grain size structure improves the mechanical properties and hardness of the new materials in comparison to microcrystalline Ti-based sinters. However, because of the porosity of approx. 20-30%, a decrease in the Young modulus is observed. Moreover, the new composites show good tendency towards covering by Ca-P compounds during soaking in SBF.

Open access

M.P. Szczepanik, P.M. Wilkołek, Ł.R. Adamek, M. Pluta, M. Gołyński, W. Sitkowski, G. Kalisz, I. Taszkun and Z.J.H Pomorski

Abstract

Non-invasive methods of skin condition assessment include, among others, the evaluation of transepidermal water loss (TEWL). The aim of the study was to examine whether TEWL values depend on horse breed. The study was conducted on four breeds: “Felin” ponies (FP) (n=16), Polish koniks (PK) (n=15), Polish cold-blooded horses (PcbH) (n=11) and Wielkopolska horses (WH) (n=12). It was found that horse breed influences TEWL values. In the neck region, statistically significant differences were found between PK and FP (p=0.006), and PK and WH (p=0.0005). In the lumbar region, there were statistically significant differences between FP and PK (p=0.0009), FP and PcbH (p=0.0016) as well as between PK and WH (p=0.000037), and PcbH and WH (p=0.0006). In the inguinal region statistically significant differences were found between FP and PK (p=0.0003), FP and PcbH (p=0.0005), PK and WH (p=0.009) and PcbH and WH (p=0.006). In the lip region statistically significant differences were observed between FP and PK (p=0.013) as well as between PK and PcbH (p=0.029) and PK and WH (p=0.009). In the examination of TEWL animal breed should be taken into consideration. The non-significant differences found in three of the examined body regions may suggest that these regions are the most adequate for TEWL assessment.