The number of urban mobility studies and projects in the three large metropoles of the Middle East and North Africa (MENA) region, Tehran, Istanbul, and Cairo, is growing while other large cities do not enjoy a large share. It would be efficient for those other large cities to adapt the experiences, projects, and studies of Tehran, Istanbul, and Cairo to their own contexts. This paper can help facilitate that adaptation. It investigates the transferability and generalisability of the findings of a recent publication by the lead author on mobility choices in Tehran, Istanbul, and Cairo to some other large cities of more than one million inhabitants in the MENA region. The discussion provided here can provide decision-makers in the MENA region with guidance on how to utilise the findings from a recent study on Tehran/Istanbul/Cairo in their own contexts. T-tests were conducted to test the comparability of the three base cities with a sample 57 others with populations of over one million people. The results show that it would be possible to adapt the urban mobility studies of the three base megacities to 3 to 27 cities based on different criteria. Key suggestions identified by this study include providing local accessibility, neighbourhood facilities, and cycling facilities as well as removing social and legal constraints to cycling, advertising cycling, informing people about the harm arising from the overuse of cars, and increasing street connectivity by adding intersections. According to the findings, these evidence-based recommendations can enhance sustainable mobility for the inhabitants of up to 27 large cities.