Objective: Comparison between the effect of monotherapy and polytherapy on cognitive functions and growth measurements among epileptic adolescents.
Methods: This study was carried on 57 adolescents from those with antiepileptics either monotherapy or polytherapy, in comparison with 20 controls. All were exposed to full neurological examination, Psychometric studies using Revised Behavior Problem Checklist “RBPC”, anthropometric measurements including height, weight, estimation of blood haemoglobin “Hb”, serum levels of copper and zinc.
Results: We found that 29 cases were with monotherapy and 28 cases were with polytherapy. Scores of RBPC revealed that conduct disorders, socialized aggression and social anxiety withdrawn scales, showed significant increase in epileptic adolescents in comparison with controls which is more in cases with polytherapy, with higher frequency in distractability and restlessness in those with monotherapy. Those with polytherapy showed high frequency in depression and psychomotor retardation. Levels of heamoglobin, copper, and zinc was statistically decreased among epileptics, more with Polytherapy. There was increase in weight and BMI with monotherapy while there was decrease in weight and BMI with polytherpy as compared with controls.
Conclusion: Epileptic patients with monotherapy scored better cognitive functions, than those with polytherapy. So we recommend monotherapy in treatment of epilepsy for better cognitive functions.
BACKGROUND: Obesity is associated with an increased risk of developing hyperinsulinemia, dyslipidemia, hypertension, premature atherosclerosis, and coronary artery disease in the future.
AIM: This study is designed to assess the relationship between serum adiponectin, asymmetric dimethylarginine (ADMA), and lipid profile among Egyptian overweight and obese children.
METHODS: This cross sectional case control study included 40 selected pre-pubertal overweight and obese children, 24 girls (60%) and 16 boys (40%) aged between 5 to 13 years (8.85 ± 2.7 years), from new cases attending the National nutrition institute clinic during 2013. Forty apparently healthy children of matched age and sex were recruited as a control group.
RESULTS: Obese group showed highly significant higher levels of serum ADMA, triglycerides, and total cholesterol compared with healthy controls (P < 0.000 in all). However, serum adiponectin levels were highly significant lower in obese children compared to healthy controls (P < 0.000). Serum ADMA showed significant positive correlations with height, serum total cholesterol and serum triglycerides levels and significant negative correlation with the body mass index and weight for age z score. Serum adiponectin showed significant negative correlations with BMI, weight, and weight for age z score and significant positive correlation with serum triglycerides. By linear regression analysis; serum adiponectin, and serum triglycerides levels were significant predictors of high serum ADMA level (p =0.045 and 0.015 respectively). BMI, weight, height and serum triglycerides were significant predictors of low serum adiponectin levels (p = 0.005, 0.022, 0.026 and 0.015 respectively).
CONCLUSIONS: Our results revealed that ADMA, Adiponectin and lipid profile can be considered as predictive biomarkers in prediction and prevention of atherosclerotic risk in the future among overweight and obese Egyptian children.