Search Results

You are looking at 1 - 9 of 9 items for

  • Author: Dušan Škiljević x
Clear All Modify Search
Open access

Jovan Lalošević and Dušan Škiljević

Abstract

Sarcoidosis is a multisystem granulomatous disease and approximately one third of patients with the systemic form develop skin lesions. We present a case of cutaneous sarcoidosis associated with autoimmune thyroiditis and vitiligo. Although this association is rare by itself, it imposes the theory of autoimmune etiology of sarcoidosis. Moreover, our patient presented with elevated levels of serum chitotriosidase, a known biomarker in the activity of systemic sarcoidosis. To the best of our knowledge, there are no reports of chitotriosidase in isolated cutaneous sarcoidosis, raising a possible field for future research.

Open access

Dušan Škiljević and Lucija Srećković

Abstract

Introduction: The incidence of melanoma has been increasing worldwide. Ultraviolet (UV) radiation from the sun and sunbeds are the major risk factors for the development of melanoma and non-melanoma skin cancers. Excessive UV exposure during childhood and adolescence increases the probablity of skin cancer in adulthood. The objective of this study was to analyze the exposure to artificial UV radiation using sunbeds among Belgrade high school students.

Material and Methods: The study was conducted using a questionnaire among 549 3rd and 4th grade students in 4 Belgrade high schools. The questionnaire included 10 questions on the sunbed use, attitudes, and general knowledge about effects of UV radiation from sunbeds. Statistical analysis assessed the frequency rate and relative frequency as methods of descriptive statistics.

Results: A total of 39% of participants had used a sunbed at least once, and 38% plan on using it in the future. When asked at what age they first used a sunbed, 45.66% of high school students stated that it was at the age of 13 or 14. Most adolescents have used a sunbed less than 5 times (38%), whereas 8% of them used it over 30 times.

Conclusion: The awareness of the risks associated with UV exposure in sunbeds is not at a satisfying level among Belgrade high school students. Educational and legislative measures are necessary to protect this highly sensitive population and prevent malignant consequences.

Open access

Branislav Lekić, Mirjana Gajić-Veljić, Dušan Škiljević, Svetlana Popadić and Ljiljana Medenica

Abstract

Apocrine adenocarcinoma is a rare form of sweat gland malignancy mostly affecting adults without evident prevalence for sex or race. Clinically, it presents as a single or a multi-nodular mass or plaque in the axillary or anogenital region, with no additional symptoms. This neoplasm is locally invasive, grows slowly and has an ability to metastasize to visceral organs, regional lymph nodes and bones. We report a case of infiltrating apocrine adenocarcinoma on the scrotum and pubic area with extramammary pagetoid spread into the groin. The immunohistological staining patterns suggested that both extramammary Paget’s disease and apocrine adenocarcinoma derived from the apocrine gland, because the tumor cells were positive for cytokeratin (CK) 7 and gross cystic disease fluid protein-15 (GCDFP-15), but negative for CK20 and prostate-specific antigen (PSA). The results of this case study will facilitate the understanding of this malignant tumor.

Open access

Jelena Perić, Branislav Lekić, Vesna Reljić, Lana Ćirković and Dušan Škiljević

Abstract

Cutaneous larva migrans (CLM) is a parasitic skin disease caused by the accidental percutaneous penetration and subsequent intraepidermal migration of larvae of various nematode parasites of the hookworm family. The hookworms responsible for CLM are spread worldwide, but the infection occurs mostly in tropical and subtropical climates. Nowadays, because of ever increasing foreign travel, the disease is no longer confined to these areas. Moreover, a significant increase of autochthonous cases in southern Europe has been observed in recent years. We report two new patients from Serbia who acquired CLM, none of them having traveled abroad. As the recommendations for the treatment of CLM are not uniform, two different treatment modalities were applied in these patients, both with an excellent response.

Open access

Jovan Lalošević, Branislav Lekić, Mirjana Gajić-Veljić, Dušan Škiljević, Katarina Đukić and Ljiljana Medenica

Abstract

Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC) is a subtype of VC, usually found on the sole of the foot.

Two patients, a 55-year-old female, and a 77-year-old male, with VC were treated at the Clinic of Dermatology and Venereology, Clinical Center of Serbia, from 2002 to 2011. Both patients presented with a tumor on the foot. Incisional biopsies showed a well differentiated squamous cell carcinoma. Foot x-rays showed bone involvement in one case. One patient underwent surgical amputation of the lower extremity, while the other had a partial amputation of the affected foot.

In the initial stage of the disease, it is difficult to distinguish pseudoepitheliomatous hyperplasia from verrucous carcinoma. The superficial biopsy of EC lesion may mislead to a histopathological diagnosis of warts or condylomas. Multiple deep biopsies are necessary for accurate and timely diagnosis of verrucous carcinoma.

Open access

Lidija Kandolf-Sekulović, Bojana Cikota, Miroslav Dinić, Dušan Škiljević and Zvonko Magić

Abstract

The diagnosis of erythroderma is challenging, since clinical, histopathological and immunophenotypic findings are insufficient to differentiate between inflammatory and lymphomatous erythroderma. Thus, multiplex PCR was used for T-cell receptor-γ gene rearrangement analysis, in the skin and peripheral blood samples of 24 patients (20 men and 4 women) with erythroderma of varying origin, in order to estimate its diagnostic value. Cutaneous T-cell lymphoma was confirmed in 9, benign inflammatory dermatosis in 12, and idiopathic erythroderma and clonal dermatitis in 3 patients. In the group of patients with erythrodermic cutaneous T-cell lymphoma, the dominant clone was detected in the skin of 8/9, and in none of the patients with inflammatory dermatoses. A dominant clone was found in peripheral blood of 5/6 samples of patients with erythrodermic cutaneous T-cell lymphoma, and in 2/12 patients with inflammatory dermatosis. T-cell receptor-γ gene rearrangement analysis is valuable in differentiation between inflammatory and lymphomatous erythroderma, thus substantially improving the diagnosis of patients with erythroderma.

Open access

Branislav Lekić, Danijela Milčić, Mirjana Popadić, Dušan Škiljević and Mirjana Milinković Srećković

Abstract

Cutaneous polyarteritis nodosa (CPAN) is a variant of polyarteritis nodosa that is limited primarily to the skin. It is a chronic recurrent disorder characterized by the presence of nodular lesions with or without ulceration on the distal third of the lower limbs. Nodular vasculitis and thrombophlebitis can be clinically or pathologically mistaken for CPAN. We present a case of a 51-year-old woman with painful nodules on the lower limbs. Some of the nodules were ulcerated. Histopathological examination of a nodule on deep incisional biopsy revealed fibrinoid necrosis of a medium-sized artery in the subcutis along with perivascular mixed infiltrate. The patient did not have any symptoms or signs of internal organ involvement. The possible etiological factor has not been detected. The patient was treated with oral prednisone 0.5 mg/kg/day and dapson 150 mg/day. Over the one-year follow-up the lesions showed regression, with one minimal relapse which resolved after the short course of oral prednisone.

Open access

Lucija Kosi, Jelena Perić, Milica Pantović, Gorana Bijelić, Jelica Vukićević Sretenović and Dušan Škiljević

Abstract

Localized bullous pemphigoid is a rare variant of bullous pemphigoid, and its exact etiopathogenesis is yet to be elucidated. We present a case of a 74-year-old Caucasian male with a 3-month history of skin lesions that appeared 9 months after he underwent a knee arthroplasty. Dermatological examination showed several pruritic tense bullae on the right knee, localized around the surgical scar, as well as erosions covered with crusts. The diagnosis of localized bullous pemphigoid was confirmed by direct immunofluorescence test (conventional and split-skin). The patient was treated with potent topical steroids, which led to complete resolution of cutaneous lesions.

We suppose that the occurrence of localized bullous pemphigoid in our patient may be explained by the concept of “immunocompromised district” in which one disease (surgery) caused an immunological alteration which is a predisposing factor for the development of secondary disease such as localized bullous pemphigoid.

Open access

Željko P. Mijušković, Lidija Kandolf-Sekulović, Danica Tiodorović, Miloš Nikolić, Marina Jovanović, Dušan Škiljević, Zorica Gajinov and Radoš D. Zečević