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Open access

Miroslav Perić, Dragana Perić and Branislav Todorović

A New Approach to Performance analysis of Point-To-Point Radio Links at Frequencies above 70 GHz

In this paper we discuss high throughput fixed point-to-point radio links in frequency bands above 70 GHz. These links are interesting as a commercial alternative to fiber connections in IP computer networks. Characteristics of equipment used for radio transmission above 70 GHz are presented. As rain is being the predominant propagation effect that causes link outages, standard rain model is described. Performance analysis in the case of adaptive radio equipment is presented. A new approach to point-to-point radio link performance analysis, that uses two dimensional rain cell models and performance criterion based on end-user experience, is proposed. This approach is compared with the standard point-to-point radio link performance analysis procedure, based on calculation of percentage of time when link is unavailable and percentage of time when link has reduced capacity. It is shown on characteristic examples that proposed performance analysis gives better insight into how rain event would really affect end-user.

Open access

Dragana Perić and Miroslav Perić

Abstract

In this paper a new structure of digital clock recovery — DCR circuit is presented. The main features of this DCR are: low complexity design, low power consumption and a single system clock operation. Thus, multiple instantiation of this type of DCR on a single chip is not complex. Due to this, such DCR can target application in energy-efficient cognitive radio systems with carrier aggregation. For performance evaluation, we have derived Markov chain based mathematical model for peak-to-peak and root mean square jitter performance analysis. The stability problem of this model, rising from the fact that some phase error states have several orders of magnitude lower probabilities than the others, is solved using mathematical apparatus for symbolic analysis. The mathematical model validity is examined by laboratorial measurements of proposed DCR for 4-PAM signal. The measurement methodology and results are described in details.

Open access

Dragana Golik-Peric, Miodrag Drapsin, Borislav Obradovic and Patrik Drid

Short-Term Isokinetic Training Versus Isotonic Training: Effects on Asymmetry in Strength of Thigh Muscles

The aim of this study was to investigate the effects of two training protocols on the isokinetic performance of athletes. The study was conducted in 38 athletes, (age 23.3 ± 3.6 years) participating in national level leagues of different sports, whose initial concentric hamstrings-to-quadriceps (conH/Q) torque ratio was lower than 0.5. During seasonal testing, an isokinetic measurement of knee extensors and flexors was performed at 60º/s. The athletes were divided into two groups. Nineteen athletes performed the isokinetic training protocol (IT) while the second group of 19 athletes followed the isotonic training protocol (RT). Both protocols lasted 4 weeks. After completing the training protocols, both groups underwent a final isokinetic testing. The isokinetic data revealed significant increases after training in measures of peak torque in both extensor and flexor muscle groups, in both the IT and RT study groups (p < 0.05). There were significant increases (p< 0.05) in conH/Q ratio in both groups after the implemented protocols, but greater in IT group. Consequently, applied IT protocol induced changes in working muscles, thereby restoring detected asymmetry to an acceptable balance more efficiently compared to RT protocol.

Open access

Dragana Janic, Jelena Peric, Teodora Karan-Djurasevic, Tatjana Kostic, Irena Marjanovic, Bojana Stanic, Nadja Pejanovic, Lidija Dokmanovic, Jelena Lazic, Nada Krstovski, Marijana Virijevic, Dragica Tomin, Ana Vidovic, Nada Suvajdzic Vukovic, Sonja Pavlovic and Natasa Tosic

Summary

Background

Acute lymphoblastic leukemia (ALL) is the most common cancer in children, whereas it is less common in adults. Identification of cytogenetic aberrations and a small number of molecular abnormalities are still the most important risk and therapy stratification methods in clinical practice today. Next generation sequencing (NGS) technology provides a large amount of data contributing to elucidation of mutational landscape of childhood (cALL) and adult ALL (aALL).

Methods

We analyzed DNA samples from 34 cALL and aALL patients, using NGS targeted sequencing TruSeq Amplicon – Cancer Panel (TSACP) which targets mutational hotspots in 48 cancer related genes.

Results

We identified a total of 330 variants in the coding regions, out of which only 95 were potentially protein-changing. Observed in individual patients, detected mutations predominantly disrupted Ras/RTK pathway (STK11, KIT, MET, NRAS, KRAS, PTEN). Additionally, we identified 5 patients with the same mutation in HNF1A gene, disrupting both Wnt and Notch signaling pathway. In two patients we detected variants in NOTCH1 gene. HNF1A and NOTCH1 variants were mutually exclusive, while genes involved in Ras/RTK pathway exhibit a tendency of mutation accumulation.

Conclusions

Our results showed that ALL contains low number of mutations, without significant differences between cALL and aALL (median per patient 2 and 3, respectively). Detected mutations affect few key signaling pathways, primarily Ras/RTK cascade. This study contributes to knowledge of ALL mutational landscape, leading to better understanding of molecular basis of this disease.