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Open access

Y Sha, Q Liu, Y Wang, C Dong and L Song

Exploring Candidate Genes for Epilepsy by Computational Disease-Gene Identification Strategy

Epilepsy is a complex disease with a strong genetic component. So far, studies have focused on experimental validation or genome-wide linkage scans for epilepsy susceptibility genes in multiple populations. We have used four bioinformatic tools (SNPs3D, PROSPECTR and SUSPECTS, GenWanderer, PosMed) to analyze 16 susceptibility loci selected from a literature search. Pathways and regulatory network analyses were performed using the Ingenuity Pathways Analysis (IPA) software. We identified a subset of 48 candidate epilepsy susceptibility genes. Five significant canonical pathways, in four typical networks, were identified: GABA receptor signaling, interleukin-6 (IL-6) signaling, G-protein coupled receptor signaling, type 2 diabetes mellitus signaling and airway inflammation in asthma. We concluded that online analytical tools provide a powerful way to reveal candidate genes which can greatly reduce experimental time. Our study contributes to further experimental tests for epilepsy susceptibility genes.

Open access

L. Teng, S. Seetharaman, M. Nzotta, P. Dong, H. Ge, L. Wang, H. Wang and A. Chychko

Retention, Recovery and Recycling of Metal Values from High Alloyed Steel Slags

The work was carried out in four parallel directions. The thermodynamic activities of oxides of Cr in steel slags were determined by slag-gas equilibration technique. The ratio of Cr2+/Cr3+ in CaO-MgO(-FeO)-AlO3-SiO2-CrO× system slags was measured by X-ray absorption near edge spectra (XANES). High-temperature mass spectrometry method was also used to obtain the distribution of chromium oxides. A mathematical correlation was established for estimating the ratio of Cr2+/Cr3+ as a function of temperature, partial pressure of oxygen and slag basicity. Laboratory investigations of the decarburization of high alloy steels under controlled oxygen potentials have been carried out to retain Cr in the steel phase. A mathematical model has been developed for the decarburization process with controlled oxygen partial pressure. Experimental and theoretical investigations have been carried out in optimizing the Mo-additions to steel in the EAF practice in Uddeholm Tooling AB. Substantial saving of Mo as well as less emissions of Mo-bearing dust are indicated in the study. A salt extraction process was developed to extract the metal values from steel slags. Successful extractions, followed by electrolysis indicate that this could be a viable route towards recovery of metals from metallurgical slags.

Open access

Yi Xu, Wei-wei Fu, Shi Chen, Yue-fang Dong, Ke-ke Gu and Li-ping Wang

Open access

Lei Dong, Zheng-Feng Wang, Peng Zhu and Wan-Hui Ye

Abstract

We report on the development and characterization of ten microsatellite markers from repetitive DNA enriched libraries for Castanopsis fissa from lower subtropical China. The number of alleles ranged from three to thirteen. Observed and expected heterozygosities ranged from 0.265 to 0.818, and 0.270 to 0.873, respectively. These microsatellite markers will be used to study fine-scale spatial genetic structure of C. fissa in 20 ha Dinghushan plot in lower subtropical China.

Open access

Jun Cheng, Min Li, Ping Gao, Jin-ling Dong and Qi Wang

Abstract

Liver steatosis is a pathological hallmark in patients with chronic hepatitis C (CHC). Increased lipid uptake, decreased lipid secretion, increased lipid synthesis and decreased lipid degradation are all involved in pathogenesis of steatosis induced by hepatitic C virus (HCV) infection. Level of low density lipoprotein receptor (LDL-R) and activity of peroxisome proliferator-activated receptor (PPAR) α is related to liver uptake of lipid from circulation, and affected by HCV. Secretion via microsomal triglyceride transfer protein (MTTP), and formation of very low density lipoprotein (VLDL) have been hampered by HCV infection. Up-regulation of lipid synthesis related genes, such as sterol regulatory element-binding protein (SREBP)-1, SREBP-2, SREBP-1c, fatty acid synthase (FASN), HMG CoA reductase (HMGCR), liver X receptor (LXR), acetyl-CoA carboxylase 1 (ACC1), hepatic CB (1) receptors, retinoid X receptor (RXR) α, were the main stay of liver steatosis pathogenesis. Degradation of lipid in liver is decreased in patients with CHC. There is strong evidence that heterogeneity of HCV core genes of different genotypes affect their effects of liver steatosis induction. A mechanism in which steatosis is involved in HCV life cycle is emerging.

Open access

Liang-xiong Dong, Yi-ran Shi and Shao-hua Wang

Abstract

The anti-impact ability of shafting affects stability and security of the ship power transmission directly. Moreover, it also cannot be ignored that the rub-impact loads have influence on the torsion vibration of ship shafting. In order to solve the problem of engineering application of reliability assessment under rub-impact loads, a test rig with rubbing generator is established. By carrying out the integrative analysis, the torsional vibration characteristics, such as vibration amplitude and orbit of axle center under the rub impact load are studied. According to the rub-impact conditions obtained through numerical simulation, the experimental verification is carried out on the test rig with rubbing generator. The results show that it is not obvious the influence of rub-impact loads upon the shafting torsion vibration except in special working conditions, that can be simulated by the rubbing generator. The maximum amplitude of torsional vibration is influenced by the radial rigidity as well as the friction coefficient of rubbing body, and the degree of influence is difference under conditions of continuous rubbing and serious rubbing. By adjusting the rigidity of stern bearing, the influence of rub-impact upon shafting can be weaken, which provides a theoretical reference for the safety evaluation of ship shafting.