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  • Author: Diana Muntean x
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The Intangible Assets Advantages in the Machine Vision Inspection of Thermoplastic Materials

Abstract

Innovation is not a simple concept but is the main source of success. It is more important to have the right people and mindsets in place than to have a perfectly crafted plan in order to make the most out of an idea or business. The aim of this paper is to emphasize the importance of intangible assets when it comes to machine vision inspection of thermoplastic materials pointing out some aspects related to knowledge based assets and their need for a success idea to be developed in a successful product.

Open access
Molecular mechanisms involved in physical exercise and factors that may influence them. particularities in patients with type 2 diabetes mellitus

Abstract

Phisical activity, regularly performed, give us a lot of health benefit, especially in preventing cardiovascular disease, diabetes mellitus (DM) and obesity. Physical exercise, defined as a controlled, progressive, supervised, requires muscular activity, involving energy consumption through metabolic and thermoregulatory processes. It can be classified as aerobic and anaerobic, according to the metabolic processes that take place. The metabolic equivalent (MET) represents the body’s energy consumption during rest and it is used for quantifying fhisical activity (for example, a MET value of 3 would require 3 times the energy that is consumed at rest). Muscle contraction has two different phases: the isometric one (usually during the first part of the contraction) and the isotonic one. This article presents the interrelation of phisical activity with with the complexity of metabolic patwais, bringing the arguments for the necessity of performing regular and controlled phisical activity.

Open access
New RP-HPLC Method for Separation of Naja haje haje Venom and Studies of its Bactericidal Effect

Abstract

Background: Snake venom is a complex mixture of biologically active substances. Some peptides and proteins from snake have already demonstrated their therapeutically potential. The venom of Naja haje, an Elapidae member, has been analyzed from this point of view. Understanding the fully biochemical role of its enzymes has determined the scientists to find new separation and identification methods.

Objective: Our goal was to develop an optimal HPLC analytical method for separation and identification of Naja haje snake venom components, known for its neurotoxic activity. In addition, we wanted to find out if crude snake venom could inhibit the development of both Gram-positive and Gram-negative bacterial cultures. Materials and Method: Analysis of venom was performed on a HPLC system using a C16 column with UV detection at 210 nm. The analysis was done using two mobile phases, containing different concentrations of acetonitrile and trifluoroacetic acid aqueous solution at different pH values. An elution gradient was set at a flow of 0.60 mL/min. Bactericidal activity was quantified by measuring inhibition diameter around an aseptically disk filled with crude venom using Staphylococcus aureus and Escherichia coli. Results: An optimal HPLC analytical method has been developed by changing different parameters such as the pH value of mobile phase A or the elution gradient. The best resolution were obtained at a pH value of 7.4, in gradient varying from 5% to 45% in mobile phase B. Microbiological studies of the venom showed that Gram-positive bacteria growth was inhibited by crude venom, while on Gram-negative bacteria growth no effect was observed. Inhibition zone is dose-dependent and fresh crude venom is with 30% more potent than venom freeze and kept at -55°C. Conclusions: A comprehensive catalog of venom composition may serve as a starting point for studying structurefunction correlations of individual toxins for the development of new research tools and drugs of potential clinical use.

Open access
Blood glucose and glycated hemoglobin evaluation: a populational study

Abstract

As the latest data from the International Diabetes Federation (IDF) have shown, diabetes mellitus (DM) prevalence and incidence are continually increasing. Our purposes were to identify the socio-demographical characteristics of the subjects diagnosed with DM prior to this study, to establish the percent they represent of the studied group, to evaluate the metabolic control of the subjects enrolled in the study, as well as to ascertain whether the blood glucose level or the glycated haemoglobin (HbA1c) measurement leads to the detection of a higher percentage of DM newly diagnosed cases. The study conducted in 3 Romanian cities enrolled 4133 subjects (1340 from Craiova, 1224 from Oradea and 1569 from Sibiu). 1413 subjects (34%) reported having been diagnosed with DM prior to our study. Most of the subjects previously diagnosed with DM, 65%, take oral antidiabetic agents (OAA), 13% take insulin and 4% take both OAA and insulin. 20% of the subjects who did not report DM had a blood glucose level ≥126mg/dL and 17% of them had an HbA1c ≥6.5%, leading to a high number of newly diagnosed DM cases, therefore emphasising the importance of the simultaneous determination of these two parameters. The results of this study confirm the increasing prevalence of DM and the necessity of future studies in order to asses DM accurate prevalence in Romania.

Open access