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  • Author: Daniela Popa x
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Climate Change’s Impact on Sandy Soils and on the Grafted Watermelons Adaptation

Abstract

Starting from the fact that the principles of agro-ecology become fundamental principles for the development of a green economy, especially in the context of current climate change, the effective capitalization of the ecological conditions of an agricultural area is one of the main objectives of agricultural science and practice. Identifying and formulating adaptive technological solutions can guide any producer to capitalize different climate and soil conditions. The sandy soils in Southern Oltenia offer less favourable ecological conditions, and the cultivation of watermelons is now profitable enough for such conditions. Growers are, however, interested in getting the most productive yields, early and profitable, even under the conditions of climate change. The current paper quantifies the grafting of watermelons in the conditions of the sandy soils of Dăbuleni, with poor soil supply, with meteorological drought phenomena and agricultural drought risk, in terms of quality and quantity of production under the climatic conditions in 2015-2017. The results, correlated with the climatic conditions, recommend the cultivation of grafted watermelons, offering the producers in the area a niche of ecological adaptation, ensuring the resistance of plants to abiotic, thermo-hydric stress factors, and improving the resistance to low temperatures, heat and drought.

Open access
Anthropometric Predictors of High Risk of Obstructive Sleep Apnea Syndrome in a Rural Population

Anthropometric Predictors of High Risk of Obstructive Sleep Apnea Syndrome in a Rural Population

Objective. To evaluate which anthropometric parameter better predicts the high risk of obstructive sleep apnea syndrome (OSA) in a rural population. Material and Method. 254 subjects were enrolled. We measured weight, height, waist circumference (WC) and neck circumference (NC) and calculated body mass index (BMI), waist-to-height ratio (WHtR) and neck circumference/height ratio (NC/Height). The risk of OSA was assessed by using Berlin Questionnaire. Results. Subjects with high risk of OSA had a significant higher BMI, WC, WHtR, NC, and NC/Height. A higher percentage of those with large WC (≥80cm and ≥94cm for women and men, respectively) (p<0.001), WHtR ≥0.5 (p<0.001), NC ≥40cm (p=0.004), NC/Height ratio ≥0.23 (p=0.002) had a high risk of OSA. Using ROC curves of anthropometric parameters studied we found that WHtR was the best predictor for high risk of OSA, with AUC of 0.760, 95% CI: 0.699 to 0.815. Conclusions. WHtR was the best predictor for high risk of OSA as assessed by the Berlin Questionnaire.

Open access
Determination of Apixaban Levels in Human Plasma by a High-Throughput Liquid Chromatographic Tandem Mass Spectrometry Assay / Determinarea rapidă a apixabanului în plasma umană prin cromatografie de lichide de înaltă performanță cuplată cu spectrometrie de masă în tandem

Abstract

A high-throughput liquid chromatography method with detection by tandem mass spectrometry (LC-MS/MS) was developed and validated for the quantification of apixaban in human plasma. The separation was performed on a Gemini-NX column under isocratic conditions using a 33:67 (v/v) mixture of acetonitrile and 1 mM ammonium formate in water at 40 ºC with a flow rate of 0.5 mL/min. The detection of apixaban was performed in multiple reaction monitoring mode (m/z 417.2 from m/z 460.2) with electrospray positive ionization. A single-step protein precipitation with methanol was used for plasma sample preparation. The method was validated with respect to selectivity, linearity (r > 0.994), intra-day and inter-day precision (CV < 14.4 %) and accuracy (bias < 9.5 %) over the range of 9.70 - 970.00 ng/mL plasma. The lower limit of quantification (LLOQ) was 9.70 ng/mL and the recovery was between 97.4 - 104.5 %. The method is fast, efficient, requires the processing of a small volume of plasma (50 μL), a short run-time (1 min) for chromatographic analysis, and a simple and rapid preparation of samples. It is very well suited for clinical therapeutic drug monitoring and pharmacokinetic studies.

Open access
Risk management, corporate governance and financial performance of the banking system in Romania

Abstract

The recent global financial crisis has raised a number of questions with regard to corporate governance of banking financial institutions. There was a series of “voices” that expressed their concern and even the lack of confidence in the role of corporate governance at the banking system level, and not only, in preventing the effects of this crisis. The main objective of this research is constituted by the study of the corporate governance influence at the banking system level in Romania on the risks management area and of banking financial performances. The used research methodology is predominantly quantitative. This methodology is based on a descriptive statistics, having as objective the analysis of corporate governance characteristics, the appreciation of the risks management level and the performances recorded at the level of the Romanian banking system. In the realisation of this study, the calculation of central tendency indicators, dispersion and form of distribution were used with the help of the SPSS software under Windows (Descriptive Statistics).

Open access
Flow Cytometry Analysis of Pparα Receptors in Metabolic Syndrome / Studiul Receptorilor Pparα prin Metoda Citometriei în Flux în Sindromul Metabolic

Abstract

Introduction. Metabolic syndrome (MS) is a cluster of distinct metabolic alterations with an increased cardiovascular risk. Peroxisome Proliferator-Activated Receptor - Alpha (PPARα), member of the nuclear receptor superfamily of transcription factors, is critically involved in the management of lipid metabolism during homeostasis or inflammatory stresses in various cell types and represents one of the therapeutic targets in MS. We analysed the PPARα expression in leukocytes of pacients with MS, in order to address PPARα involvement in these group of diseases. Material and method. Our study included 57 adult patients recruited under informed voluntary consent, investigated in order to establish whether they present MS, according to International Diabetes Federation (IDF) European guidelines and grouped in 2 lots: the MS Lot (26 patients) and control group, non-MS Lot (31 subjects). Common clinical and laboratory parameters targeted in MS evaluation were determined for all the studied cases. The expression levels of 2 molecules, PPARα and CD36 were evaluated in various circulating leukocyte populations of these patients by an optimized flow cytometry method. Statistic analysis clarifying the significance of value differences for various parameters measured was performed under SPSS and simple statistical tests (Pearson, t-Student, Chi -test). Results and discussion. The fluorescence staining for PPARα were significantly dimmer when comparing the cellular expression in eosinophils (p<0.05) of MS versus the Control group of subjects. Conclusions: Our study is the first to show that circulating eosinophils display significantly reduced PPARα protein expression in MS patients. The differences in key molecule expression in circulating leukocytes (like PPAR species, CD36, and other) might be evocatory for the endothelial dysfunction and obesity and might be of use in the therapeutic decision.

Open access
Communication as a Key Issue in the Care of Diabetes Mellitus

Abstract

The physician-patient communication has an essential role in establishing and supporting the relationship between these two partners. Moreover, modern medicine highlights the patient-centered approach. Publications assessing the impact of an efficient physicianpatient communication on medical care results in diseases such as diabetes and hypertension have revealed a positive correlation between patient’s satisfaction about the communication with the physician and values of blood pressure, glycated hemoglobin and pain intensity. Interventions needed in both doctors and patients for developing communication abilities were paid special attention in order to achieve an appropriate improvement in their communicative interaction during periodical appointments. In the field of diabetes mellitus, the medical challenge is to improve patients’ knowledge about medical care; this aim is achieved only by therapeutic education, using high-quality communication techniques.

Open access
Odontogenic suppurative rhinosinusitis with oculo-orbital and cerebral complications - case series

Abstract

BACKGROUND. Odontogenic rhinosinusal suppurations have a high potential for major ocular-orbital and cerebral complications because of the presence of anaerobic bacteria flora, with continuity, contiguity and haematogenous propagation mechanisms. This pathology is often diagnosed in other departments than ENT such as ophthalmology, neurosurgery or OMF surgery.

MATERIAL AND METHODS. We present three clinical cases of odontogenic rhinosinusal suppurations with major complications: a 36-year-old patient with odontogenic pansinusitis complicated with orbital phlegmon and cerebral frontal lobe abscess; a 19-year-old patient with complicated maxillary-ethmoidal-frontal sinusitis complicated with frontal subdural empyema and frontal bone osteomyelitis (with a history of craniofacial trauma one year before); a 66-year-old patient with odontogenic maxillary-ethmoidal sinusitis complicated with orbital apex syndrome.

RESULTS. The treatment was surgical, by external approach, with endoscopic nasal control, in interdisciplinary teams. We have associated massive antibiotic therapy. Surgical drainage for complicated rhinosinusitis should be done in emergency, within the first 24 hours after admission, according to guidelines. The bacteriological examination for aerobic and anaerobic flora can guide the diagnosis - two cases associated maxillo-ethmoidal aspergilloma lesions. The evolution of the cases was favourable.

CONCLUSION. Interdisciplinary teams have successfully solved these complicated odontogenic rhinosinusal suppurations. Two of the cases were admitted and cured within 2 weeks, in the context of very hot weather, which exacerbated dormant dental infections.

Open access
Blood glucose and glycated hemoglobin evaluation: a populational study

Abstract

As the latest data from the International Diabetes Federation (IDF) have shown, diabetes mellitus (DM) prevalence and incidence are continually increasing. Our purposes were to identify the socio-demographical characteristics of the subjects diagnosed with DM prior to this study, to establish the percent they represent of the studied group, to evaluate the metabolic control of the subjects enrolled in the study, as well as to ascertain whether the blood glucose level or the glycated haemoglobin (HbA1c) measurement leads to the detection of a higher percentage of DM newly diagnosed cases. The study conducted in 3 Romanian cities enrolled 4133 subjects (1340 from Craiova, 1224 from Oradea and 1569 from Sibiu). 1413 subjects (34%) reported having been diagnosed with DM prior to our study. Most of the subjects previously diagnosed with DM, 65%, take oral antidiabetic agents (OAA), 13% take insulin and 4% take both OAA and insulin. 20% of the subjects who did not report DM had a blood glucose level ≥126mg/dL and 17% of them had an HbA1c ≥6.5%, leading to a high number of newly diagnosed DM cases, therefore emphasising the importance of the simultaneous determination of these two parameters. The results of this study confirm the increasing prevalence of DM and the necessity of future studies in order to asses DM accurate prevalence in Romania.

Open access