The norms and standards for design of timber bridges, as well as other structures built from this material, were obsolete, design standards that were used dated from 1978 to 1980. The introduction of European Standards has created a new legislative framework in the field of designing and building timber bridges. Currently the design of such constructions use Norm NP 005-2003 and SR EN 1995-1-1: 2004 Eurocode 5: Design of timber structures. Part 1-1: General. Common rules and rules for buildings, SR EN 1995-2: 2005 Eurocode 5: Design of timber structures. Part 2: Bridges, along with their national annexes. The aim of this paper is to analyze the design of the beams for timber bridges in parallel, using on one hand Norm NP 005 - 2003, and on the other hand provisions of European standards. The design requirements for both norms as well as the results of a case study for a structural element of a timber bridge will be presented.
Introduction: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by a late onset (it is rare in children), aggressive phenotype and dismal prognosis especially in patients in the older group (>65 years). For risk stratification of patients standard cytogenetic is used along with molecular techniques for point mutation identification. Here we describe a new method using next generation sequencing for identification of mutation in 5 AML recurrently mutated genes - RUNX1, FLT3, DNMT3A, IDH1 and IDH2. Materials and methods: Samples from 40 patients with normal karyotype AML referred to Fundeni Clinical Institute were sequenced. Primer design was performed using LaserGene Genomics suit. Next generation sequencing was performed on MiSeq (Illumina) and results were analyzed using LaserGene Genomics suit. Results of next generation sequencing were compared to Sanger sequencing. Results: No additional mutations were identified in samples from nine patients presenting FLT3-ITD and/or NPM1 mutations. In 25 out of 31 patients with normal karyotype and no FLT3-ITD and NPM1 mutations, we identified mutations in one of the 5 aforementioned genes. All these mutations identified by next generation sequencing were confirmed using the classical Sanger sequencing. Conclusions: We validated a very useful method for mutation identification in AML patients using next generation sequencing. There are many advantages exhibited by this method: it is more cost efficient and it has a higher sensitivity of mutation detection than Sanger sequencing, it has been described as being quantitative and in our case it allowed risk stratification for most of the normal karyotype AML samples which were FLT3-ITD and NPM1 negative.
În cadrul articolului cu titlul „Beton monolit versus beton prefabricat la execuția în consolă a podurilor” vor fi abordate o serie de probleme care apar atât la proiectarea cât şi la execuţia structurilor de poduri din beton precomprimat utilizând metoda execuţiei în consolă.
Această metodă a revoluţionat podurile din beton, din punct de vedere al deschiderilor şi al uşurinţei traversării unor obstacole dificile. În afara avantajelor realizării unor structuri din beton monolit prin execuţie în consolă, utilizarea elementelor prefabricate conduce la micşorarea semnificativă a timpului de execuţie şi la diminuarea problemelor care pot apărea din cauza curgerii lente şi a contracţiei betonului.
Materialul prezentat în cadrul articolului cu titlul „Beton monolit versus beton prefabricat la execuția în consolă a podurilor” va prezenta principiul metodei de execuţie în consolă, avantajele utilizării acestei metode, cazurile particulare pentru care se pretează o astfel de structură, scheme statice şi secţiunile transversale adoptate pentru acest tip de structuri, cât şi modul de îmbinare al tronsoanelor prefabricate în funcţie de generaţia din care fac parte.
De asemenea, se va prezenta un studiu de caz în care vor fi analizate cele doua variante de execuție în consolă (turnare monolită a tronsoanelor respectiv montare de tronsoane prefabricate) și vor fi prezentate concluzii privind oportunitatea utilizării uneia dintre cele două variante.
BACKGROUND. Ultrasonography has been used in rhinology for diagnosing trauma lesions (fractures, hemosinus), second opinion in tumoral pathology, screening for sinusitis, but on a small scale and with future prospects of cost efficiency.
OBJECTIVE. We hope to grow awareness of the possible use of ultrasound in screening for nasal and paranasal sinuses pathology at the level of ENT emergency departments.
MATERIAL AND METHODS. We describe the technique for ultrasound examination of this region, emphasizing the need for a profound anatomical knowledge characteristic for ENT specialists. Any specialist having access to an ultrasound machine is encouraged to experiment with this imaging procedure. Two cases benefited from the use of ultrasonography in order to receive a better management and a swift treatment. One case presented with a maxillary sinus tumor and another with a paranasal tumor neighbouring the orbit.
CONCLUSION. Ultrasonography of nasal and paranasal sinuses permits serial examination without irradiating the patient; it could be implemented as an addition to FAST-like protocols at the level of emergency departments in order to screen for occult head and neck pathology prior to conventional radiology and CT imaging and thus reducing costs
Blockchain is a concept that tends to revolutionize the world of finance in a technological leap that allows fast, secure and decentralized transactions. The Blockchain technology is used in virtual coins (bitcoin) conditions, with a high innovation potential, applicable in various areas, with the advantage of storing databases, resulting in an unprecedented level of transparency in the private or public area. Interestingly, under the bitcoin conditions, the black chain system uses a decentralized peer-to-peer payment system. Practically, the bitcoin can be considered as the most appropriate triple game accounting system. All of these considerations are developing in the big data era, which is defined as a large, diverse, high-volume information base requiring new forms of processing. Big data is important for businesses because based on these, strategic and marketing decisions can be made to optimize the activity in the market conditions and consumer preferences. European Union directives provide for measures to ensure the development of all states and, in this context, the community. At the same time, some measures provide for a more accelerated development for states with a low accession. For this, funds have been made from which important amounts are allocated to these states. The complex development of the European Union aims, in fact, to improve the quality of life (standard of living) in all Member States. At the European community level there are databases usable in economic analyzes. Also, Eurostat is the institution with the most complex databases. Recently, the Conference of the Directors of the Institute of Statistics in the European States analyzed the perspective of calculating the indicators in the context of the big data to be implemented. The article focuses on the concrete study of the use of large data in the calculation of the indicators that underlie the comparability between the EU Member States.
In this paper is presented the design solution and experimental prototype of a wheelchair for disabled people. Design solution proposed to be implemented uses two reduction gears motors and a mechanical transmission with chains. It’s developed a motion controller based on a PWM technology, which allows the user to control the wheelchair motion. The wheelchair has the ability of forward – backward motion and steering. The design solution is developed in Solid Works, and it’s implemented to a wheelchair prototype model. Wheelchair design and motion makes him suitable especially for indoor use. It is made a study of the wheelchair kinematics, first using a kinematic simulation in Adams. Are presented the wheelchair motion trajectory and kinematics parameters. The experimental prototype is tested with a motion analysis system based on ultra high speed video cameras recording. The obtained results from simulation and experimentally tests, demonstrate the efficiency of wheelchair proposed solution.
In this paper are presented the author’s researches on designing, dynamical and structural evaluation of a transmission for a wheelchair, intended to persons with locomotors disabilities. The kinematics of proposed transmission is analyzed in order to realize a proper synthesis and design of gears. A 3D model of the transmission and wheelchair are designed in Solid Works, and they will be used for the dynamic simulation of the wheelchair robotic system in Adams software. In Adams is analyzed wheelchair trajectory and dynamics for a combined trajectory: linear motion and steering. Dynamic parameters obtained from simulation are used to perform a finite element analysis of bevel and worm gears. Simulation results reveal the transmission dynamics parameters, emphasize the efficiency of the transmission and enable implementation of this design to a wheelchair model.
BACKGROUND. Odontogenic rhinosinusal suppurations have a high potential for major ocular-orbital and cerebral complications because of the presence of anaerobic bacteria flora, with continuity, contiguity and haematogenous propagation mechanisms. This pathology is often diagnosed in other departments than ENT such as ophthalmology, neurosurgery or OMF surgery.
MATERIAL AND METHODS. We present three clinical cases of odontogenic rhinosinusal suppurations with major complications: a 36-year-old patient with odontogenic pansinusitis complicated with orbital phlegmon and cerebral frontal lobe abscess; a 19-year-old patient with complicated maxillary-ethmoidal-frontal sinusitis complicated with frontal subdural empyema and frontal bone osteomyelitis (with a history of craniofacial trauma one year before); a 66-year-old patient with odontogenic maxillary-ethmoidal sinusitis complicated with orbital apex syndrome.
RESULTS. The treatment was surgical, by external approach, with endoscopic nasal control, in interdisciplinary teams. We have associated massive antibiotic therapy. Surgical drainage for complicated rhinosinusitis should be done in emergency, within the first 24 hours after admission, according to guidelines. The bacteriological examination for aerobic and anaerobic flora can guide the diagnosis - two cases associated maxillo-ethmoidal aspergilloma lesions. The evolution of the cases was favourable.
CONCLUSION. Interdisciplinary teams have successfully solved these complicated odontogenic rhinosinusal suppurations. Two of the cases were admitted and cured within 2 weeks, in the context of very hot weather, which exacerbated dormant dental infections.