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  • Author: Dan Wei x
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Abstract

Drug-induced liver injury (DILI) is defined as injury to the liver caused by exposure to a drug or some drugs. The number of cases suffering from DILI has been increasing. There are few clinical features specifically associated with DILI. The recognition and diagnosis of DILI is difficult. In this report, we described a DILI case caused by herbal remedies.

Abstract

The interactions between stiffness and workspace performances are studied. The stiffness in x, y and z directions as well as the workspace of a 3-UPU mechanism are studied and optimized. The stiffness of the robotic system in every single moveable direction is measured and analyzed, and it is observed that in the case where one tries to make the x and y translational stiffness larger, the z directional stiffness will be reduced, i.e. the x and y translational stiffness contradicts with the one in z direction. Subsequently, the objective functions for the summation of the x and y translational stiffness and z directional stiffness are established and they are being optimized simultaneously. However, we later found that these two objectives are not in the same scale; a normalization of the objectives is thus taken into consideration. Meanwhile, the robotic system’s workspace is studied and optimized. Through comparing the stiffness landscape and the workspace volume landscape, it is also observed that the z translational stiffness shows the same changing tendency with the workspace volume’s changing tendency while the x and y translational stiffness shows the opposite changing tendency compared to the workspace volume’s. Via employing the Pareto front theory and differential evolution, the summation of the x and y translational stiffness and the volume of the workspace are being simultaneously optimized. Finally, the mechanism is employed to synthesize an exercise-walking machine for stroke patients.

Abstract

A linkage map for Betula platyphylla Suk was constructed based on RAPD, ISSR, AFLP and SSR markers by a pseudo-testcross mapping strategy. A F1 segregating population including 80 progenies was obtained from the cross between two superior trees selected from Qinghai and Wangqing provenance, respectively. The paternal map was constructed with 282 markers consisting of 14 major and 15 minor (5 triplets and 10 doublets) linkage groups and spanning 1131 cM at an average distance of 4.0 cM between adjacent markers. The maternal map has 277 markers consisting of 15 major and 8 minor (5 triplets and 3 doublets) groups covering 1288 cM at an average distance of 4.6 cM between adjacent markers. In the same pedigree we investigated association of genetic markers with seedling stem height and circumference. The composite interval mapping was used to detect the number of quantitative trait loci and their position on the genetic linkage maps. Three QTLs (one on the male map and two on the female map) were found explaining 13.4%, 17.5% and 18.8% of the trait variation, respectively.

Objective To evaluate the efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial.

Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n = 220) or combined with TCM (Reduning or Xiyanping injections) (n = 232). The primary outcome was the incidence rate of rash/herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days.

Results The rash/herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and 67.2% (156/232) in TCM and Western medicine combined therapy group, with significant difference (P < 0.001). Moreover, TCM remarkably increased the incidence rate of secondary disappearance, which was 56.4% in Western medicine therapy group and 71.4% in TCM and Western medicine combined therapy group (P = 0.001). No drug-related adverse events were observed.

Conclusions It’s suggested that the integrative TCM and Western medicine therapy achieved a better therapeutic efficacy. TCM may become an important complementary therapy on relieving the symptoms of HFMD.