In this paper, an area and power efficient current mode frequency synthesizer for system-on-chip (SoC) is proposed. A current-mode transformer loop filter suitable for low supply voltage is implemented to remove the need of a large capacitor in the loop filter, and a current controlled oscillator with additional voltage based frequency tuning mechanism is designed with an active inductor. The proposed design is further integrated with a fully programmable frequency divider to maintain a good balance among output frequency operating range, power consumption as well as silicon area. A test chip is implemented in a standard 0.13 µm CMOS technology, measurement result demonstrates that the proposed design has a working range from 916 MHz to 1.1 l GHz and occupies a silicon area of 0.25 mm2 while consuming 8.4 mW from a 1.2 V supply.
Background: Ablizia julibrissin could inhibit the proliferation of cancer cells in vitro and in vivo. However, the effects of the compositions Julibroside J8 and J12 on the angiogenesis are still poorly understood.
Objective: We compared the pharmacodynamics of julibroside J8 and J12 in inhibiting angiogenesis in vitro and in vivo.
Methods: Julibroside J8 and J12 were separated from the crude extract of Ablizia julibrissin. The effects of julibroside J8 and julibroside J12 on growth, migration, and matrigel tube formation of human microvascular endothelial cells (HMEC-1) were explored. In addition, the in vivo anti-angiogenic effect of julibroside J8 and J12 was evaluated on a chorioallantoic membrane (CAM).
Results: HMEC-1 cells showed dose-dependent inhibition of growth, migration, and tube formation, when treated with 0.5-4 μg/ml julibroside J8 or 0.1-0.5 μg/ml julibroside J12 respectively. The formation of microvessels on CAM was also inhibited by julibroside J8 or julibroside J12 at concentrations of 10-100 μg.egg-1 or 5-50 μg.egg-1 respectively.
Conclusion: Julibroside J12 confers more potent inhibitory effect on angiogenesis than julibroside J8 does.
Nowadays the development of Internet of Things (IoT) technology has witnessed great changes in the world. As it has often been mentioned, IoT Environment Monitoring Technologies and IOT Smart Home Technologies have been gradually accepted by people and have good prospects for development. Now we can research a networking based intelligent platform to monitor our forest environmental factors in time with the new IoT technology based on ZIGBEE protocol. ZIGBEE based networking technologies has the advantages of low power dissipation, low data rate and high-capacity transportation, which makes it more suitable for the design of the node of forest environmental factors collection platform. So, we are going to discuss a kind of IoT forest environment factors collection platform based on ZIGBEE protocol.
Objective: To identify the common sites and risk factors of community-associated infections in Chinese patients with diabetes. Materials and Methods: The Wanfang, CNKI, PUBMED and VIP databases restricting to Chinese patients with diabetes were queried without restriction to time period. Randomized controlled trials (RCTs) on the risk factors of community-associated infections in Chinese patients with diabetes were considered. Polled odd ratios (OR) and 95% confidence intervals (95% CI) were used for each factor in fixed or random-effect metaanalyses. Results: Twelve studies were identified that investigated seven risk factors of community-associated infections in Chinese patients with diabetes. The average infection incidence was 39.55%. The respiratory tract and urology tract were the predilection sites. Meta-analysis results are as follows: Diabetic patients with chronic complications (OR: 1.63; 95% CI 1.45-1.82), advanced age (OR: 1.30; 95% CI 1.19-1.42), longer duration (OR: 1.47; 95% CI 1.35-1.61) or ketoacidosis (OR: 1.37; 95% CI 1.13-1.66) were more prone to suffer from infections. Those with better glycemic control (OR: 0.68; 95% CI 0.61-0.76) or males (OR: 0.69; 95% CI 0.64-0.75) were less prone to suffer from infections. Conclusion: Chinese patients with diabetes had a high incidence of community-associated infections. We should highlight the risk factors that might provide a reference for the same.
To systematically review the knowledge attitudes and the influential factors on human papillomavirus (HPV) vaccination among Chinese women.
Published studies on knowledge and attitudes of HPV vaccination for preventing cervical cancer among Chinese female population were retrieved using the major Chinese and English databases. Meanwhile, handwork retrieval was also conducted and the references including in the literature were retrieved. The quality of the literature was rigorously evaluated and extracted independently by two researchers and the data were analyzed and described by review manager 5.3 (RevMan5.3) software.
In all, 19 articles including 8 articles in Chinese and 11 in English were chosen. A total of 30,176 participants were included and the sample size ranged from 64 to 6,024. The overall awareness of HPV and HPV vaccine among Chinese women was at a low level. Chinese women generally showed poor knowledge about HPV and HPV vaccine. Acceptance of HPV vaccination among Chinese women was at a high level. Vaccination intentions were influenced by the theory of planned behavior (TPB) and measured by attitudes subjective norms and perceived behavioral control.
The health authorities may evaluate and develop TPB-based interventions to increase HPV vaccination intentions of Chinese women. HPV vaccination programs should focus on carrying out multi-level and targeted health education and developing effective public health strategies after balancing the cost and benefit of HPV vaccine program. Medical staff should play the positive role in promoting the use of HPV vaccines in China. Integration of policy and community perspectives and multi-level interventions are essential to maximize the public health benefits of HPV vaccination.
There is little information focusing on the nutritional issue of pediatric recipients before they receive living donor liver transplantation. This study illustrates the relationship between nutritional status and graft liver function and provides a reference regarding nutritional interventions in future studies.
We prospectively collected data from 30 pediatric living donor liver transplant recipients from January 1, 2016, to June 30, 2016. The information included demographic data, preoperative nutritional assessment, and postoperative laboratory examinations. The nutritional assessment included the serum concentration of vitamin D, bone density, trace element, and weight Z value. The laboratory examinations included white blood cell count, neutrophil percentage, hemoglobin, blood platelet, total protein, albumin, total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase (AST), alkaline phosphatase, gamma-glutamyl transpeptidase, creatinine, bile acid, blood glucose (Glu), prothrombin time, international normalized ratio, tacrolimus concentration, and graft-to-recipient weight ratio (GRWR). The data were collected on Days 1, 2, 3, 4, 5, 6, 7, 14, 30, and 60 after liver transplantation.
The recipients consisted of 15 (50%) males and 15 (50%) females. The median age was 7 months (4–48 months). The mean height and weight were 69.07±9.98 cm and 8.09±2.63 kg, respectively. According to the univariate analysis, the gender, diagnosis, blood type, and GRWR did not significantly impact the liver function after the operation. The posttransplantation AST levels and Glu showed significant differences in terms of the nutritional status, with P<0.05. The multivariate correlation analysis showed that the serum concentrations of vitamin D and AST were midrange positively correlated, with P<0.05.
The nutritional status of patients with biliary atresia is relatively poor. There is a definite midrange positive correlation between nutrition and graft liver function that might play a relatively important role in the recovery of the graft.
Detection of incipient degradation demands extracting sensitive features accurately when signal-to-noise ratio (SNR) is very poor, which appears in most industrial environments. Vibration signals of rolling bearings are widely used for bearing fault diagnosis. In this paper, we propose a feature extraction method that combines Blind Source Separation (BSS) and Spectral Kurtosis (SK) to separate independent noise sources. Normal, and incipient fault signals from vibration tests of rolling bearings are processed. We studied 16 groups of vibration signals (which all display an increase in kurtosis) of incipient degradation after they are processed by a BSS filter. Compared with conventional kurtosis, theoretical studies of SK trends show that the SK levels vary with frequencies and some experimental studies show that SK trends of measured vibration signals of bearings vary with the amount and level of impulses in both vibration and noise signals due to bearing faults. It is found that the peak values of SK increase when vibration signals of incipient faults are processed by a BSS filter. This pre-processing by a BSS filter makes SK more sensitive to impulses caused by performance degradation of bearings.
Objective To evaluate the efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial.
Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n = 220) or combined with TCM (Reduning or Xiyanping injections) (n = 232). The primary outcome was the incidence rate of rash/herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days.
Results The rash/herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and 67.2% (156/232) in TCM and Western medicine combined therapy group, with significant difference (P < 0.001). Moreover, TCM remarkably increased the incidence rate of secondary disappearance, which was 56.4% in Western medicine therapy group and 71.4% in TCM and Western medicine combined therapy group (P = 0.001). No drug-related adverse events were observed.
Conclusions It’s suggested that the integrative TCM and Western medicine therapy achieved a better therapeutic efficacy. TCM may become an important complementary therapy on relieving the symptoms of HFMD.
Introduction: Peroxiredoxin 6 (Prdx6) is a bifunctional protein with glutathione peroxidase activity and phospholipase A2 activity. Previous studies have shown a significant positive correlation between the intracellular survival ability of Brucella and Prdx6. Here, the Prdx6 enzyme with a single activity was constructed to facilitate study of the relationship between the single function of Prdx6 and Brucella infection.
Material and Methods: The target open reading frame (ORF) DNAs of Prdx6 with a single active centre were prepared using gene splicing by overlap extension PCR (SOE-PCR), and the recombinant eukaryotic expression plasmids inserted by Prdx6 with the single activity centre were constructed and transfected into murine Raw264.7 macrophages. The glutathione peroxidase activity and phospholipase A2 activity of the constructed Prdx6 were examined.
Results: The core centres (Ser32 and Cys47) of Prdx6 were successfully mutated by changing the 94th nucleotide from T to G and the 140th nucleotide from G to C in the two enzyme activity cores, respectively. The constructed recombinant plasmids of Prdx6 with the single active centre were transfected into murine macrophages showing the expected single functional enzyme activity, which MJ33 or mercaptosuccinate inhibitors were able to inhibit.
Conclusion: The constructed mutants of Prdx6 with the single activity cores will be a benefit to further study of the biological function of Prdx6 with different enzyme activity.