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  • Author: Cristina Grigore x
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Mana Totali, Felicia G. Gligor, Marius Bojita, Camelia Grigore and Cristina Grigore

Abstract

Objectives: Reference values are fundamental for the interpretation of laboratory results, which are useful for medical decisions. Each laboratory has to have its own reference values classified according to age groups in order to interpret test results correctly. The expression “normal values” has been replaced by “reference values” because there are various variables that are considered to influence these values. The majority of “reference values” were established over two decades ago using obsolete medical devices and in many cases undefined populations; therefore, nowadays these intervals are not relevant anymore for modern testing technology in clinic laboratories. Methods and materials: The study was carried out at Sibiu Clinic Pediatric Hospital using the laboratory’s electronic archive. The samples were taken from hospitalized patients (children and teenagers) and outpatients registered between January and December, 2010. Blood sample testing was performed using the Sysmex XS 1000i analyzer. The reference values for hemoglobin was calculated based on results from a population sample of 9838 patients. The patients were classified into 3 age categories: 1 month - 2 years old; 2 - 10 years old; 10 - 18 years old. Reference values were determined after eliminating outliers,using the robust method to calculate 2.5 and 97.5 percentiles with the SPSS statistical software. Results and Conclusions: The results obtained differed from those specified in the Roche Diagnostics 2004 Guide but were found to be close to the results mentioned in Lothar Thomas’s publication, in Laboratory diagnostics.

Open access

Adela Cristina Lazar, Mihaela Hedesiu, Aranka Ilea, Grigore Baciut, Mariana Pacurar and Radu-Septimiu Campian

Abstract

Purpose: The present study aims radiological aspects of the occurrence of osteonecrosis of the jaw age groups both in receiving i.v bisphosphonates tratment Imaging assessment of bisphosphonates therapy-induced osteonecrosis of the jaw it is important to differentiate neoplastic invasion, osteomyelitis, osteoradionecrosis induced by radiation or bone related pathology of general diseases.

Material and method: We conducted a retrospective clinical study including 22 patients (8 men and 14 women) with various stages of osteonecrosis of the jaw.

Results: Radiological examinations using CBCT are required in all therapeutic approach of osteonecrosis of jaw cases providing accurate informations of position, dimension and the link with anatomical structures.Our study showed that the prevalence of osteonecrosis of mandibular growth is higher in women than in men and the risk of osteonecrosis of the jaw in appearance is depending on age factor witch occurs more often between age 52-59 and 73-80 years old.

Conclusion: The multitude of complications due to treatment with bisphosphonates bind to an early and specialized therapeutic approach. Radiological examinations is a first choice in the detection and early diagnosis of osteonecrosis of the jaw, patients requiring a permanent supervision by the physician and dentist.

Open access

Carmen Denise Căldăraru, Dorin Ionuţ Tarta, Mirela Liana Gliga, Cristina Tarta, Emilian Caraşca, Sorin Albu, Adina Huţanu, Maria Dogaru and Grigore Dogaru

Abstract

Introduction: Hepcidin is a regulatory protein in iron metabolism; we do not know the role in chronic kidney disease anemia. Methods: 22 patients with CKD anemia and 15 patients with CKD without anemia were investigated. CKD anemia-inclusion criteria: over 18 years, hemoglobin ≤12 g/dl for women and ≤13 g/dl for men, no treatment for anemia 6 months before enrollment, glomerular filtration rate (eGFR) <60 ml/min/1.73m2 and stable creatinine three months before enrollment. Exclusion criteria: infection, bleeding, malignancy, systemic or liver disease, immunosuppression, renal replacement therapy. CKD without anemia-inclusion criteria: over 18 years, no anemia or treatment for anemia, CKD with stable creatinine values three months before enrollment. Exclusion criteria: medical conditions known to have a role in the development of polycythemia. Hepcidin-25 and ferritin were measured by ELISA method. Erythropoietin (EPO), tumor necrosis factor (TNF)-α, interleukin (IL)-6 were evaluated using chemiluminescent enzyme immunometric assays. Unpaired T test, Pearson correlation and multiple regression were used for statistical analysis. Results: Hemoglobin values were significantly lower in anemia group. There were no differences in terms of eGFR, age, body mass index, serum hepcidin, erythropoietin, fibrinogen, IL-6, and TNF-α between CKD patients with and without anemia. Serum hepcidin correlated positively with ferritin (r=0.45 p<0.05), TNF-α (r=0.54, p<0.05) and negatively with erythropoietin (r=-0.51, p<0.05). Multiple linear regression analysis demonstrated that TNF-α is an independent predictor of serum hepcidin in our patients (p=0.003, R=0.71). Conclusion: We found no differences in serum hepcidin, erythropoietin and inflammatory markers in non-dialysis CKD patients with and without anemia.