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Cristina Coman and Sanda Manea

Abstract

Romania represents one of Europe’s countries with high landslides occurrence frequency. Landslide hazard maps are designed by considering the interaction of several factors which, by their joint action may affect the equilibrium state of the natural slopes. The aim of this paper is landslides hazard assessment using the methodology provided by the Romanian national legislation and a very largely used statistical method. The final results of these two analyses are quantitative or semi-quantitative landslides hazard maps, created in geographic information system environment. The data base used for this purpose includes: geological and hydrogeological data, digital terrain model, hydrological data, land use, seismic action, anthropic action and an inventory of active landslides. The GIS landslides hazard models were built for the geographical area of the Iasi city, located in the north-east side of Romania.

Open access

Cristin Coman, Carmen Cristina Surdu-Bob, Florica Barbuceanu, Ene Vlase and Marius Badulescu

Abstract

The aim of this paper was to present a histological evaluation of the treatment performed on a humanmodel of osteomyelitis induced in rabbits. Osteomyelitis was induced in rabbits by a human strain of Staphylococcus aureus injected in bone defects created in the rabbit tibia. There have been created five groups of animals, groups receiving treatment in two different stages of the disease, acute and chronic. Copper and silver sub-millimetre-particles were introduced in the same place with the Staphylococcus solution. Evaluation of installation and evolution of the disease was done by clinical, hematological, microbiological, radiological and histological monitoring. A separate study of histological data is presented here. Histological examinations performed by HE was done on 5 μm sections of uncalcified bone. Every examination was classified according to a system of score. The results of histopathological evaluation confirm that histological analysis is a powerful tool in experimental models of this disease.

Open access

Mahu Ştefania Corina, Hăncianu Monica, Agoroaei Luminiţa, Coman Băbuşanu Anda Cristina and Butnaru Elena

Abstract

Arterial hypertension is a complex disease with many serious complications, representing a leading cause of mortality. Selective beta-blockers such as metoprolol and bisoprolol are frequently used in the management of hypertension. Numerous analytical methods have been developed for the determination of these substances in biological fluids, such as liquid chromatography coupled with mass spectrometry, gas chromatography coupled with mass spectrometry, high performance liquid chromatography. Due to the complex composition of biological fluids a biological sample pre-treatment before the use of the method for quantitative determination is required in order to remove proteins and potential interferences. The most commonly used methods for processing biological samples containing metoprolol and bisoprolol were identified through a thorough literature search using PubMed, ScienceDirect, and Willey Journals databases. Articles published between years 2005-2015 were reviewed. Protein precipitation, liquid-liquid extraction and solid phase extraction are the main techniques for the extraction of these drugs from plasma, serum, whole blood and urine samples. In addition, numerous other techniques have been developed for the preparation of biological samples, such as dispersive liquid-liquid microextraction, carrier-mediated liquid phase microextraction, hollow fiber-protected liquid phase microextraction, on-line molecularly imprinted solid phase extraction. The analysis of metoprolol and bisoprolol in human plasma, urine and other biological fluids provides important information in clinical and toxicological trials, thus requiring the application of appropriate extraction techniques for the detection of these antihypertensive substances at nanogram and picogram levels.

Open access

Dorel Badea, Ghiţă Aramă, Marian Coman, Olga Maria Cristina Bucoveţchi and Gabriel Mănescu

Abstract

The critical infrastructure protection domain, through its social implications, is a relatively new research topic, and a science in this regard is not setup yet. Its complexity, through the operational subsumed areas, through the interdependencies and cascading possible effects, through the many facets for investigation, is a special one which imposes specific approaches. This paper intends to continue the investigations in this field, which are conducted in an individual manner or by research teams, by authors with concerns in this regard who agreed to allocate to the topical subject a special attention based on its importance, beyond an exclusive approach – as a special topic. This time, there are brought into attention the issues related to chemical industry sector correlated with actual associated implications of necessary transportation activities in this field. Simulation-based scenario is the main technique employed as a research methodology by using dedicated software.

Open access

Dorel Badea, Crenguţa Macovei, Olga Maria Cristina Bucoveţchi and Marian Coman

Abstract

Through this article it is brought to attention the essential aspects related to the perceived risks for critical infrastructure, both theoretically and practically, considering perception as an important input in the risk management process. For the practical part, the added value component in the field consists from the results of research based on survey, conducted in a wider framework of determining the level of awareness of the critical infrastructure issue by a pilot sample, consisting of persons with managerial and operational attributions in this sector.

Open access

Vlad Budu, Andreea Costache, Tatiana Decuseara, Alexandru Coman, Alexandra Guliga, Raluca Baican, Alexandru Panfiloiu, Ioan Bulescu, Cristina Goanta, C. Ionita and Mihail Tusaliu

Abstract

The authors present a case of recurrent frontal rhinosinusitis, for which the drug therapy was ineffective. To avert the risk of complications, multiple classic and endoscopic surgical procedures were performed on the frontal sinus pathology.

The bacterium involved in this form of rhinosinusitis was represented by a Methicillin-resistant Staphylococcus aureus (MRSA) diagnosed during the first endoscopic approach (the second surgical procedure) for which the treatment corresponding to the antibiogram was followed. At the last hospitalization, the patient has underwent a frontal bilateral drainage surgery (modified Lothrop procedure) and started an adequate anti-MRSA treatment.

The authors wondered whether multiple recurrences of frontal rhinosinusitis are determined by an incomplete drainage, by a persistent infection with MRSA or by both.

Open access

Paula Ionilă, Ruxandra Jurcuţ, Nicoleta Ferariu, Monica Roşca, Monica Chivulescu, Adriana Mursă, Sebastian Militaru, Alin A. Ionescu, Cristina Căldăraru, Ana G. Fruntelată, Silvia F. Goanţă, Simina Crişan, Adina Ionac, Ana-Maria Avram, Attila Frigy, Radu Sascău, Cătălina Arsenescu-Georgescu, Ioan M. Coman, Bogdan A. Popescu, Carmen Ginghină and Eduard Apetrei

Abstract

Introduction. Hypertrophic cardiomyopathy (HCM) is a disease with increased left ventricular (LV) wall thickness not solely explained by abnormal loading conditions, with great heterogeneity regarding clinical expression and prognosis. The aim of the present study was to collect data on HCM patients from different centres across the country, in order to assess the general characteristics and therapeutic choices in this population.

Methods. Between December 2014 and April 2017, 210 patients from 11 Romanian Cardiology centres were enrolled in the National Registry of HCM. All patients had to fulfil the diagnosis criteria for HCM according to the European Society of Cardiology guidelines. Clinical, electrocardiographic, imaging and therapeutic characteristics were included in a predesigned online file.

Results. Median age at enrolment was 55 ± 15 years with male predominance (60%). 43.6% of the patients had obstructive HCM, 50% non-obstructive HCM, while 6.4% had an apical pattern. Maximal wall thickness was 20.3 ± 4.8 mm (limits 15-37 mm) while LV ejection fraction was 60 ± 8%. Heart failure symptoms dominated the clinical picture, mainly NYHA functional class II (51.4%). Most frequent arrhythmias were atrial fibrillation (28.1%) and non-sustained ventricular tachycardia (19.9%). Mean sudden cardiac death risk score (SCD-RS) was 3.0 ± 2.3%, with 10.4% of the patients with high risk of SCD. However, only 5.7% received an ICD. Patients were mainly treated with beta-blockers (72.9%), diuretics (28.1%) and oral anticoagulants (28.6%). Invasive treatment of LVOT obstruction was performed in a small number of patients: 22 received myomectomy and 13 septal ablation. Cardiac magnetic resonance was reported in only 14 patients (6.6%).

Conclusions. The Romanian registry of HCM illustrates patient characteristics at a national level as well as the gaps in management which need improvement – accessibility to high-end diagnostic tests and invasive methods of treatment.