Jun Cheng, Min Li, Ping Gao, Jin-ling Dong and Qi Wang
Liver steatosis is a pathological hallmark in patients with chronic hepatitis C (CHC). Increased lipid uptake, decreased lipid secretion, increased lipid synthesis and decreased lipid degradation are all involved in pathogenesis of steatosis induced by hepatitic C virus (HCV) infection. Level of low density lipoprotein receptor (LDL-R) and activity of peroxisome proliferator-activated receptor (PPAR) α is related to liver uptake of lipid from circulation, and affected by HCV. Secretion via microsomal triglyceride transfer protein (MTTP), and formation of very low density lipoprotein (VLDL) have been hampered by HCV infection. Up-regulation of lipid synthesis related genes, such as sterol regulatory element-binding protein (SREBP)-1, SREBP-2, SREBP-1c, fatty acid synthase (FASN), HMG CoA reductase (HMGCR), liver X receptor (LXR), acetyl-CoA carboxylase 1 (ACC1), hepatic CB (1) receptors, retinoid X receptor (RXR) α, were the main stay of liver steatosis pathogenesis. Degradation of lipid in liver is decreased in patients with CHC. There is strong evidence that heterogeneity of HCV core genes of different genotypes affect their effects of liver steatosis induction. A mechanism in which steatosis is involved in HCV life cycle is emerging.
Xiao-Xi Liu, Wei-Hua Liu, Ma Ping, Cheng-Yao Li, Xiao-Ying Liu and Ping Song
The aim of this study was to explore the correlation between psychological resilience and social support and anxiety in obstetric nurses and to provide theoretical basis for improving the mental health of obstetric nurses.
In this study, 190 obstetric nurses were included, using the general information questionnaire and The Connor-Davidson Resilience Scale (CD-RISC), Social Support Rating Scale, and survey of Self-evaluation of Anxiety Scale.
There are differences in the type of work and the score of psychological resilience (P <0.05), obstetric nurses’ resilience score was 65.58±10.65; self-rating anxiety score of obstetric nurses was 36.89±6.87; and social support score of obstetric nurses was 44.37±7.86. The psychological elasticity score and anxiety were negatively related (P <0.01), whereas the resilience score and total score of social support were positively related (P <0.01).
Obstetric nurses have many responsibilities and stress. Nursing managers should focus on obstetric nurses’ mental health, lighten the obstetric nurses’ anxiety, and thus improve their mental flexibility and optimize the quality of nursing service better, with more passion into work.
Tie-long Zheng, Ping-an Wang, Dian-li Wang, Cheng-fu Sun, Yuan Hong, Qi Wang and Jun Cheng
Objective To observe the biological function of human 3-hydroxyisobutyrate dehydrogenase (HIBADH).
Methods Human 3-hydroxyisobutyrate dehydrogenase (HIBADH, 3-hydroxy-2-methyl propanoate: NAD+ oxidoreductase) recombinant protein was expressed in E. coli BL21, and purified by Ni+ column. The special antisera was obtained from rabbits immunized by this purified antigen. On the distribution of HIBADH, it was found that HIBADH over-expressed in the injured liver cells when serious hepatitis occurred. The phenomenon was confirmed in the animal models of SD rats with acute liver cell injury induced by CCl4, but this phenomenon did not exist in the models induced by endotoxin combined with galactosamine. Further more, HIBADH’s overexpression in liver cells will induce cell necrosis through the pathway of oxidative stress.
Results When the liver cells injured by drug or other chemical materials, HIBADH will be compensationally over-expressed for the deficiency of energy, so liver cells can make enough ATP through brand-chain amino acid catabolism. However, the overexpression of HIBADH will be harmful for liver cells through the product of much more active oxygens which will induce the cell necrosis.
Conclusions HIBADH over-expression is a signal of the liver cell metabolism injury, and it can aggravate the liver cell injury through oxidative stress.
Cheng Ping and Zhao Jiaqun
To solve the off grid problem in compressed sensing (CS) based inverse synthetic aperture radar (ISAR) imaging, a fast and accurate algorithm has been proposed in the paper. By jointly estimating the off grid error and the sparse solution, off grid ISAR imaging is transformed into a joint optimization problem. Interestingly, it can be solved efficiently through two least squares problems based on first order Taylor approximation. When applied to complex sinusoids and quasi real ISAR data, the proposed algorithm has got better results than the conventional algorithm. Therefore, it is a promising off grid CS based ISAR imaging algorithm.
Cheng Ping, Shi Liu and Zhao Jiaqun
To solve off-grid problem in compressed sensing, a new reconstruction algorithm for complex sinusoids is proposed. The compressed sensing reconstruction problem is transformed into a joint optimized problem. Based on coordinate descent approach and linear estimator, a new iteration algorithm is proposed. The results of experiments verify the effectiveness of the proposed method.
Cheng Ping and Zhao Jiaqun
To improve the performance of inverse synthetic aperture radar (ISAR) imaging based on compressed sensing (CS), a new algorithm based on log-sum minimization is proposed. A new interpretation of the algorithm is also provided. Compared with the conventional algorithm, the new algorithm can recover signals based on fewer measurements, in looser sparsity condition, with smaller recovery error, and it has obtained better sinusoidal signal spectrum and imaging result for real ISAR data. Therefore, the proposed algorithm is a promising imaging algorithm in CS ISAR.
Yi-sheng Zhong, Min-hong Xiang, Wen Ye, Ping Huang, Yu Cheng and You-qin Jiang
Background: Retinal ganglion cells (RGCs) are protected in rats with acute elevated intraocular pressure (IOP) by Erigeron breviscapus (vant.) hand-mazz (EBHM). However, it is unclear whether EBHM has neuroprotective effect on RGCs in animal with chronic elevated IOP.
Objective: Investigate the protective effect of EBHM extract on RGCs in rabbits with chronic elevated IOP.
Methods: Unilateral chronic elevated IOP was produced in rabbits by repeated injection of 2% methylcellulose into the anterior chamber. Secondary degeneration was measured with and without EBHM extract treatment for 60 days. At 60 days, the cells density of the RGCs layer, the thickness of retinal nerve fiber layer (RNFL), and the optic nerve axons were observed and analyzed using an image analysis system. The ultrastructural changes of RGCs and optic nerve axons were observed using transmission electron microscopy.
Results: Compared with their contralateral control eyes with normal IOP, in the retinas of 3-4 mm from the optic disc, the cells density of the RGCs layer in the eyes with chronic elevated IOP was 23.2±6.5 cells (n = 6) and 36.0±8.9 cells (n = 10) per three 400x fields at 60 days in untreated and EBHM-treated group, respectively. The RNFL thickness in eyes with chronic elevated IOP was 3.4±0.4 μm (n = 6) and 5.0±1.0 μm (n = 10) at 60 days in untreated and EBHM-treated group, respectively. The axons number per 15057.8 μm2 in eyes with chronic elevated IOP was 370.4±41.0 (n = 6) and 439.0±50.8 (n = 10) at 60 days in untreated and EBHM-treated group, respectively. The number of the organelles in RGCs plasm appeared decreased and mitochondrion vacuolated in the elevated IOP eyes of EBHM-treated group, while some dispersive mitochondrion and rough surfaced endoplasmic reticulum and ribosome still existed in the RGCs plasm. The myelin sheath plates condensed and degenerated, and the microfilaments and microtubules decreased or disappeared in the elevated IOP eyes, but the axons degeneration in the chronic elevated IOP with EBHM treatment was less than that in the chronic elevated IOP without treatment.
Conclusion: EBHM extract provided a neuroprotective effect on retinal ganglion cells in rabbits with chronic elevated IOP.
Ninga Sun, Ying-chaoa Zhang, Wei-guoa Zhang, En-lua Cheng and Yun-ping
In order to effectively solve condensation and icing problems of radiosonde in low-temperature environment at high altitude, humidity sensor heated automatic alternately to remove pollution and improve the measurement accuracy. Heat experiments obtained the curve of rising temperature and responsible time on heated twin humidity sensor in normal temperature and pressure, by expanded responsible curve to obtain heated model of twin heated humidity sensor and by the analysis of heating model, use DMC and PID control for heating respectively. Simulation results show that the DMC control meets the practical requirements of measure at high altitude.
Xin Li, Ping Liang, Jie Yu, Xiao-Ling Yu, Fang-Yi Liu, Zhi-Gang Cheng and Zhi-Yu Han
Background. The aim of the study was to evaluate the efficiency and feasibility of contrast-enhanced ultrasound (CEUS) with Sonovue in assessing of renal cell carcinomas (RCCs) following ultrasound (US)-guided percutaneous microwave ablation (MWA).
Patients and methods. Seventy-nine patients (60 males and 19 females) with 83 lesions (mean size 3.2±1.6 cm) were treated by US-guided percutaneous MWA. The CEUS results of the third day after the ablation were compared with the synchronous contrast-enhanced computed tomography (CT)/magnetic resonance imaging (MRI) results and biopsy pathological results. The follow-up was performed by CEUS and CT/MRI after 1, 3, 6 months and every 6 months subsequently. The combination of clinical follow-up results and CT/MRI imaging findings was the reference standard of CEUS results for evaluating the therapeutic effect. The identification of residual or recurrence tumour was assessed by two blinded radiologists.
Results. On the third day after MWA, CEUS showed 68 of 83 lesions (68/83, 81.9%) successfully ablated and 15 of 83 (18.1%) with residual tumours. Among residual tumours, 13 (86.7%) were confirmed by contrast-enhanced CT/MRI findings and biopsy results. The sensitivity, specificity, accuracy, positive and negative predictive value of CEUS evaluating the short-term MWA effectiveness were 100%, 97.1%, 97.6%, 86.7% and 100%, respectively. During the six years follow-up (median 26 months), the CEUS showed recurrence in 7 patients, and six of them achieved consistent results on CEUS and CT/MRI imaging. The sensitivity, specificity, accuracy, positive and negative predictive value for CEUS evaluating long-term MWA effectiveness were 85.7%, 98.7%, 97.6%, 85.7% and 98.7%, respectively.
Conclusions. The post-procedural CEUS demonstrated as an effective and feasible method in evaluating a therapeutic effect of RCCs following MWA.