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Junping Chen and Jiexian Wang

Reduced-Dynamic Precise Orbit Determination for Low Earth Orbiters Based on Helmert Transformation

A model based on Helmert transformation is presented in reduced-dynamic Precise Orbit Determination(POD). As an implementation, a reduced-dynamic POD approach was developed. The approach includes two steps: firstly, kinematic POD and then reduced-dynamic POD. Based on the approach, a set of programs were developed. POD of CHAMP and GRACE was then carried out. Kinematic and reduced-dynamic POD for CHAMP and GRACE satellite over 2 weeks time show that reduced-dynamic orbits of CHAMP have a mean 3D RMS of 0.26 m compared to PSO orbit of GFZ, and the mean 3D RMS of GRACE-A has the same value compared to GNV1B orbit of JPL. The 3D RMS is reduced by up to 40% compared to kinematic solutions.

Open access

Zhengrong Xiang, Ronghao Wang and Qingwei Chen

Fault tolerant control of switched nonlinear systems with time delay under asynchronous switching

This paper investigates the problem of fault tolerant control of a class of uncertain switched nonlinear systems with time delay under asynchronous switching. The systems under consideration suffer from delayed switchings of the controller. First, a fault tolerant controller is proposed to guarantee exponentially stability of the switched systems with time delay. The dwell time approach is utilized for stability analysis and controller design. Then the proposed approach is extended to take into account switched time delay systems with Lipschitz nonlinearities and structured uncertainties. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.

Open access

Cheng Chen, Yigang Wang and Huiming Huang

Abstract

Large scaled projects are conducted in South Yellow Sea in recent years. Topographic effect and tidal current are key issues to the coastal engineering and the ocean engineering. In this study, field surveys were conducted to investigate the tidal level, current velocity, and current direction in South Yellow Sea. A numerical model was developed to simulate the radial current field based on the field data. To investigate the mechanism of the radial current field, the actual topography and a smoothed topography were applied in the numerical model, respectively. Results show that, the current field appeares radial because of the tidal system rather than the submarine topography. Local topography centralized the radiation centre and shifted the high-velocity zones. The actual topographic effect is proposed, and results show that local topography increases the flood tide velocity and decreases the ebb tide velocity. Lagrangian residual currents are calculated to illustrate possible sediment sources and transport routes.

Open access

Guo Yanhua, Zhou Sihua, Zhou Xiaodong, Chen Bojun and Wang Shaohui

Abstract

Defect Detection is one of the most important parts of Automatic Identification and Data transmission. Quick Response code (QRcode) is one of the most popular types of two-dimensional barcodes. It isachallenge to detect defect of various QRcode images efficiently and accurately. In this paper, we propose the procedure byaserial of carefully designed preprocessing methods. The defect detection procedure consists of QRcode identification, QRcode reconstruction, perspective transformation, image binarization, morphological operation, image matching, and Blob analysis. By these steps, we can detect defect of different types of QRcode images. The experiment results show that our method has stronger robustness and higher efficiency. Moreover, experiment results on QRcode images show that the prediction accuracy of proposed method reaches 99.07%with an average execution time of 6.592 ms. This method can detect defect of these images in real time.

Open access

Huangyuan Li, Siying Wu, Junnian Chen, Bo Wang and Nian Shi

Transcription factor NF-E2-related factor 2 (Nrf2) is important for cell protection against chemical-induced oxidative stress. Previously, we have reported that in PC12 cells, Nrf2 can be triggered by deltamethrin (DM), a commonly used pyrethroid insecticide. Molecular mechanisms behind Nrf2 activation by DM are still unclear. Here we studied the effects of cell glutathione (GSH) depletion on Nrf2 activation by DM. We found that DM enhanced Nrf2 expression at the mRNA and protein levels and increased nuclear Nrf2 levels. Activation of Nrf2 was associated with activation of its downstream targets, such as heme oxygenase-1 (HO-1) and glutamate cysteine ligase catalytic subunit (GCLC). In contrast, DL-buthionine-[S,R]- sulfoximine (BSO), a known GSH-depleting agent, did not increase Nrf2 protein expression or cause its nuclear accumulation. However, pre-treatment with BSO triggered mRNA expression of HO-1 and GCLC. Furthermore, BSO pre-treatment suppressed DM-induced Nrf2 upregulation and activation and lowered mRNA expression of HO-1 and GCLC upon DM treatment. These data demonstrate that GSH depletion is not necessary for the activation of Nrf2/ARE by DM in PC12 cells, and that GCLC and HO-1 expression can increase through other signalling pathways.

Open access

Chen Wang, Guidong Yu, Wei Sun and Jinde Cao

Abstract

The adjacency matrix of a graph is a matrix which represents adjacent relation between the vertices of the graph. Its minimum eigenvalue is defined as the least eigenvalue of the graph. Let Gn be the set of the graphs of order n, whose complements are connected and have pendent paths. This paper investigates the least eigenvalue of the graphs and characterizes the unique graph which has the minimum least eigenvalue in Gn.

Open access

Fengling Wang, Jin Chen, Wenting Dai, Zhengmin He, Dandan Zhai and Weidong Chen

Abstract

In order to investigate the potential of nanostructured lipid carriers for efficient and targeted delivery of curcumin, the pharmacokinetic parameters of curcumin-loaded nanostructured lipid carriers (Cur-NLC) were evaluated in rats after a single intraperitoneal dose of Cur-NLC. In addition, the anticancer activity of Cur-NLC against human lung adenocarcinoma A549 cells was verified by a cellular uptake study, and a cytotoxicity and apoptosis assay. Bioavailability of Cur-NLC was better than that of native curcumin (p > 0.01), as seen from the area under the plasma concentration-time curve (AUC), maximum plasma concentration (C max), mean residence time (MRT) and total plasma clearance (CLz/F). Cur-NLC has a more obvious lung-targeting property in comparison with native curcumin. Cur-NLC showed higher anticancer activity in vitro against A549 cells than native curcumin (IC 50 value of 5.66 vs. 9.81 mg L−1, respectively). Meanwhile, Cur-NLC treated A549 cells showed a higher apoptosis rate compared to that of native curcumin. These results indicate that NLC is a promising system for the delivery of curcumin in the treatment of lung adenocarcinoma.