The worldwide implementation of school governance reforms over the last decades has changed the function and roles of school principals. Now identified as key players, these changes expose them to new health risks. International research has established the principalship to be highly demanding and stressful. This study addresses work stress, its main causes and coping strategies among school principals in French-speaking Switzerland. While they are most frequently bothered by time stressors, coping efforts are primarily directed at reducing or preventing conflictual interpersonal relations.