The purpose of this research consists in the elucidation of spatial and branch aspects of the water use in the river basins of Republic of Moldova. The main topics presented in this paper are: 1) the dynamics of water use; 2) spatial and branch profile of water use and its dynamics: 3) existing problems in the evaluation and monitoring of water use. To achieve these objectives were used traditional methods of geographical and economic research. Also, the content of the present study is focused on the methodology to elaborate the management plans of hydrographical basins and their chapters on economic analysis of water use in the river basin. of Republic of Moldova.