Mesenchymal stem cells (MSC) were described by Friedenstein in the 1970s as being a group of bone marrow non-hematopoietic cells that are the source of fibroblasts. Since then, knowledge about the therapeutic potential of MSCs has significantly increased. MSCs are currently used for the treatment of many diseases, both in adults and children. MSCs are used successfully in the case of autoimmune diseases, including rheumatic diseases, diabetes mellitus type 1, gastroenterological and neurological diseases. Moreover, treatment of such organ disorders as damage or hypoxia through application of MSC therapy has shown to be satisfactory. In addition, there are some types of congenital disorders, including osteogenesis imperfecta and Spinal Muscular Atrophy, that may be treated with cellular therapy. Most studies showed no other adverse effects than fever. Our study is an analysis that particularly focuses on the registered trials and results of MSCs application to under 18 patients with acute, chronic, recurrent, resistance and corticosteroids types of Graft-versus-Host Disease (GvHD). Stem cells currently play an important role in the treatment of many diseases. Long-term studies conducted on animals have shown that cell therapy is both effective and safe. The number of indications for use of these cells in the course of treatment of people is constantly increasing. The results of subsequent studies provide important data justifying the application of MSCs in the course of treatment of many diseases whose treatment is ineffective when utilizing other approaches.
The relationship between energy value and nutrients intake and the body shape and size parameters (weight, height, waist and hip circumferences) has become an interesting research area for nutritionists and dieticians. The aim of this study was to determine the relationship between the body shape and size parameters (weight, height, waist and hip circumferences), somatotype (according to the Rohrer (RI) index) and energy value and nutrients intake of women. The study was conducted in 2014 and 2016 on 148 female volunteers aged 57-88 from the Mazovian and Lublin province (Poland). Sample selection was targeted at elderly people with different body types. The exclusion criteria were: multi-organ failure, cancer and disability. Then among the subjects, a survey was conducted, that included demographic data, lifestyle, health status and vitamins and minerals supplements use. Food intake has been assessed using a 3-day dietary food records. The somatotype was determined using the RI with the Curtis key, classifying the subjects as ectomorphic (n=30), mesomorphic (n=31) and endomorphic (n=87). The somatotype was significantly related to place of residence, physical activity, waist and hip circumference, WHR and BMI index, total protein intake, animal protein intake, vitamin E intake (p≤0.05) and to fat, phosphorus and thiamine intake (p≤0.1). The obtained results showed that the place of residence, physical activity, chronic diseases, the use of specialized diet, body weight fluctuations, BMI and WHR were different depending on the somatotype in the examined group of women. Endomorphic subjects had significantly greater waist and hip circumference and diastolic blood pressure compared to the other somatotypes. The somatotype had only a significant effect on total protein, animal protein and vitamin E intake, and ectomorphic elderly women may be particularly susceptible to nutrient deficiencies. Due to the risk of macronutrient, vitamin and mineral deficiencies in the diets of the examined women, it seems necessary to educate this group as well as caregivers and doctors in the area of nutrition adapted to the needs of the elderly.
The prohibition of antibiotic use in edible snails obligates breeders to treat bacterial infections by different means, of which a common one is a bath in Gram-positive– and partially Gram-negative–bactericidal ethacridine lactate solution. The aim of the study was to determine the effect of bathing Cornu aspersum Müller snails in a 0.1% aqueous solution of ethacridine lactate on selected physiological parameters of haemolymph.
Material and Methods
The study included 80 snails, divided into two equal groups (study and control). The study group was subjected to bathing in ethacridine lactate and the control group to bathing in tap water. Both groups were treated daily for seven days. The number of haemocytes in the haemolymph, the activity of alanine (ALT) and aspartate (AST) aminotransferases, and the concentration of urea were determined.
In the study group, after exposure to ethacridine lactate solution an increase in ALT activity, changes in the De Ritis ratio, an increase in the amount of haemocytes, and a decrease in body weight were found. No such changes were detected in the control group snails or in animals after the first bath.
Multiple applications of a 0.1% ethacridine lactate bath may adversely affect Cornu aspersum Müller snails.
Introduction. Due to their dynamic character, allergic conditions pose challenges for modern medicine and constitute a public health problem. Nearly 40% of the general Polish population is estimated to suffer from an allergy. We would like to emphasize that allergies are not some extraordinary ailments; instead, they commonly coincide with or are complications of other systemic conditions. Hence, national health policies should prioritize the development and implementation of ready-to-use protocols that focus mainly on prevention rather than treatment.
Conclusions. In an outpatient setting the care for individuals who suffer from allergies is facilitated by therapeutic teams. Allergy nurses play a special role in this framework, with the scope of their professional duties including diagnostic procedures, treatment, being a mediator for patient education initiated by the therapeutic team. This article focuses on three important types of allergy nurses‘ responsibilities: diagnostic procedures (e.g. skin prick tests), therapeutic procedures (allergen-specific immunotherapy), and selected aspects of medical record-keeping.