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Armands Sīviņš, Jānis Misiņš, Corrado Pedrazzani, Guntis Ancāns, Aivars Stengrēvics, Viesturs Krūminš, Viesturs Boka and Mārcis Leja

Epidemiology and Surgical Treatment of Gastric Cancer in Latvia

The aim of the study was to evaluate short- and long-term results of surgical treatment of gastric cancer performed in Latvia Oncology Centre. Retrospectively data was collected from 461 patients who underwent gastrectomy with curative intent in the Latvia Oncology Centre from January 2001 to December 2005. The data was subjected to statistical analysis. On average, 92.2 (range 81-102) R0-R1 gastrectomies were performed each year. Post-operative complications occurred in 75 patients (16.3%); in-hospital mortality was 3.3%. The overall 5-year survival was 50.8%. In 444 cases (96.3%) there was histopathologic confirmation of R0-resection with a 5-year survival of 52.5% (P < 0.001). Considering pT category, 5-year survival (median) was 88.6% (not reached) for pT1 patients, 65% (not reached) for pT2, 42.3% (35.7 months) for pT3 and 27% (14.2 months) for pT4 (P < 0.001). Considering the pN category, 5-year survival (median) was 67% (not reached) for pN0 patients, 30% (22.1 months) for pN1 and 29% (14.2 months) for pN2-3 (P < 0.001). Short- as well as long-term results are comparable with Western experiences, but not for pN+ patients where no difference between pN1 and pN2 cases was observed.

Open access

Georgijs Moisejevs, Linda Gailīte, Sergejs Isajevs, Liene Ņikitina-Zaķe, Inga Kempa, Dainius Jančiauskas, Ilze Ķikuste, Armands Sīviņš, Guntis Ancāns and Mārcis Leja

Abstract

Histamine has an important role in the process of the gastric mucosa inflammation acting via histamine receptor H2 (encoded by the gene HRH2). Single nucleotide polymorphism of the enhancer element of HRH2 gene promoter rs2067474 (1018G>A)may be associated with changes of expression of the receptor. We attempted to clarify the association of this polymorphism with gastric cancer and/or atrophic gastritis in the Latvian (Caucasian) population. The study group consisted of 121 gastric cancer patients and 650 patients with no evidence of gastric neoplasia on upper gastrointestinal endoscopy. Genotyping for rs2067474 was performed with the TaqMan probe-based system using a commercially available probe for RT-PCR. The frequency of the A allele in the gastric cancer group was 0.41% and in the control group — 1.54% (p = 0.231). No significant differences were found comparing genotypes between gastric cancer versus control patients (OR = 0.236, CI95% = 0.030–1.896), patients with (n = 165) versus without (n = 485) gastric metaplastic lesions (OR = 0.854, CI95% = 0.288–2.540) and patients with (n = 297) and without (n = 353) gastric atrophic lesions (OR = 1.145, CI95% = 0.451–2.906). Our findings suggest that the HRH2 -1018G>A polymorphism (rs2067474) is neither associated with gastric cancer nor the grade of atrophic gastritis in the Latvian (Caucasian) population.