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Open access

Sima Qamhiyeh, Anna Wysocka-Rabin and Oliver Jäkel

Abstract

Better knowledge of CT number values and their uncertainties can be applied to improve heavy ion treatment planning. We developed a novel method to calculate CT numbers for a computed tomography (CT) scanner using the Monte Carlo (MC) code, BEAMnrc/EGSnrc. To generate the initial beam shape and spectra we conducted full simulations of an X-ray tube, filters and beam shapers for a Siemens Emotion CT. The simulation output files were analyzed to calculate projections of a phantom with inserts. A simple reconstruction algorithm (FBP using a Ram-Lak filter) was applied to calculate the pixel values, which represent an attenuation coefficient, normalized in such a way to give zero for water (Hounsfield unit (HU)). Measured and Monte Carlo calculated CT numbers were compared. The average deviation between measured and simulated CT numbers was 4 ± 4 HU and the standard deviation σ was 49 ± 4 HU. The simulation also correctly predicted the behaviour of H-materials compared to a Gammex tissue substitutes. We believe the developed approach represents a useful new tool for evaluating the effect of CT scanner and phantom parameters on CT number values.

Open access

Andrzej Radwański, Anna Wysocka and Marcin Górka

ABSTRACT

Radwański, A., Wysocka, A. and Górka, M. 2012. Miocene burrows of the Ghost Crab Ocypode and their environmental significance (Mykolaiv Sands, Fore-Carpathian Basin, Ukraine). Acta Geologica Polonica, 62 (2), 217-229. Warszawa. The huge lithosome of the Middle Miocene (Early Badenian) Mykolaiv Sands, developed at the external margin of the Fore-Carpathian Basin in western Ukraine, is recognized to represent a shallowing-up sequence. Special attention is paid to burrows of the Ghost Crab Ocypode which are pantropical in present-day littoral habitats. In the Stratyn section, burrows of this type become a crucial tool in the interpretation of basin bathymetry, which starts from distal offshore depths, through the foreshore, to the backshore where the Ocypode burrows record a temporary break in sedimentation. Lithification of the sand layers and the Ocypode burrows subsequently progressed in beachrock mode. The Stratyn section demonstrates that the development of submerged shoals and/or emergent parts, throughout the huge mass of the Mykolaiv Sands, is probably responsible for their great variation in thickness in western Ukraine, which has long proved difficult to explain.

Open access

Andrzej Radwański, Marcin Górka and Anna Wysocka

Abstract

Echinoderms from the Badenian (Middle Miocene) of the Fore-Carpathian Basin of western Ukraine are facies restricted. The Mykolaiv Beds, stratigraphically older, yielded the starfish Astropecten forbesi (complete skeletons), two genera of sand dollars (Parascutella, Parmulechinus), and numerous other echinoids of the genera Psammechinus , Echinocyamus, Spatangus, Hemipatagus, Echinocardium, Clypeaster, Echinolampas, and Conolampas. The stratigraphically younger, calcareous Ternopil Beds yielded Eucidaris (complete coronae, isolated spines), Arbacina , Brissus, and Rhabdobrissus. Sixteen species of echinoids are distinguished and/or commented. A new brissid, Rhabdobrissus tarnopolensis sp. nov., is established. A mass occurrence of some species (Psammechinus dubius and Hemipatagus ocellatus) contrasts with that of mass aggregations (sand dollars and Echinocardium leopolitanum) by dynamic events in selected layers of proximal tempestites. Of special note is the occurrence of very small specimens, interpreted as juveniles (‘babies’) having been swept out of their restricted biotopes (‘nurseries’). Some species hitherto regarded as of Early Miocene age, and the problem of their persistence beyond the Fore-Carpathian Basin and/or migration into that basin during the Middle Miocene transgression are discussed.

Open access

Anna Wysocka, Andrzej Radwański, Marcin Górka, Maciej Bąbel, Urszula Radwańska and Michał Złotnik

Abstract

Studies of Miocene sediments in the Fore-Carpathian Basin, conducted by geologists from the University of Warsaw have provided new insights on the distribution of the facies infilling the basin, particularly in the forebulge and back-bulge zones. The origin of the large-scale sand bodies, evaporitic deposits and large-scale organic buildups is discussed, described and verified. These deposits originated in variable, shallow marine settings, differing in their water chemistry and the dynamics of sedimentary processes, and are unique with regard to the fossil assemblages they yield. Many years of taxonomic, biostratigraphic, palaeoecologic and ecotaphonomic investigations have resulted in the identification of the fossil assemblages of these sediments, their age, sedimentary settings and post-mortem conditions. Detailed studies were focused on corals, polychaetes, most classes of molluscs, crustaceans, echinoderms, and fishes.

Open access

Anna Snarska, Dominika Wysocka, Liliana Rytel, Krystyna Makowska and Sławomir Gonkowski

Abstract

Introduction

Bisphenol A (BPA) is a substance widely used in industry for the production of polycarbonates and epoxy resins used in packaging and containers for beverages, contact lenses, compact discs (CDs), window panes, and many other elements. This compound belongs to the group of polyphenols and xenoestrogens commonly found in the human environment. What we know about BPA is still insufficient to enable us to protect our health against its adverse effects, and current knowledge of the influence of BPA on erythroblastic cell lines in bone marrow is rather fragmentary. The aim of the experiment was to assess the effect of two doses of BPA (0.05 mg/kg and 0.5 mg/kg b.w. per day) on myeloid haematopoiesis.

Material and Methods

During this experiment, the number of all types of cells in the erythroblastic cell line was evaluated in porcine bone marrow before and after BPA administration.

Results

The obtained results clearly indicate changes in haematopoietic activity of the bone marrow, which was demonstrated by a decrease in erythroblastic cell line production in both experimental groups. The haematological effects of the bone marrow changes were anaemia, caused by a number of erythrocytes which was depressed due to their immaturity, and a significant decrease in mean cellular volume in both groups.

Conclusion

The harmful effect of high and low doses of BPA on haematopoietic processes was proved.

Open access

Anna Snarska, Dominika Wysocka and Liliana Rytel

Abstract

Introduction: Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the statin simvastatin on thrombopoiesis in the porcine model because it is the closest to the human one regarding physiological and genetic similarities.

Material and Methods: The study was conducted on a group of 32 pigs randomly divided into two equal groups: control and experimental. The pigs were treated for 28 and 56 days with simvastatin in a dose of 40 mg per day per animal. Cytological evaluation of bone marrow smears was performed to assess the average number of all types of cells during thrombopoiesis as was analysis of haematological parameters to assess PLT and MPV.

Results: During the course of the experiment statistically significant changes in the number of promegakaryocytes were observed. Other parameters also showed some fluctuations during the study. However, these changes were not statistically significant.

Conclusion: The obtained results clearly indicate a toxic influence of simvastatin on the process of thrombopoiesis and prove that statins reduce mean platelet volume, thus affecting the process of clot formation through the period of administration in a duration-dependent manner.

Open access

Anna Wysocka, Fabian Welc and Urszula Czarniecka

Abstract

A gravel horizon is preserved in several locations within the world-wide known archaeological site in Saqqara (northern Egypt). It is characterized by a variable thickness, composed of coarse, quartz, quartzitic and flint pebbles, and considered to correspond to gravels of the Edfu Formation, deposited in the Early Pleistocene by the early phase of the Nile development (Protonile Phase). This relatively short (ca. 200 ka) and at the same time very dynamic period of Protonile activity during the Edfu Pluvial is one of the most poorly recognized hydrological-climatic episodes of the Quaternary in north-eastern Africa. This paper is focused on the preliminary sedimentological-petrographic characteristics of these deposits and an attempt to indicate their source areas as well as mechanisms of transportation and deposition in the context of Pleistocene pluvial episodes.

Open access

Maciej Łoziński, Piotr Ziółkowski and Anna Wysocka

Abstract

The Orava Basin is an intramontane depression filled with presumably fine-grained sediments deposited in river, floodplain, swamp and lake settings. The basin infilling constitutes a crucial record of the neoalpine evolution of the Inner/Outer Carpathian boundary area since the Neogene, when the Jurassic-Paleogene basement became consolidated, uplifted and eroded. The combination of sedimentological and structural studies with anisotropy of magnetic susceptibility (AMS) measurements provided an effective tool for recognition of terrestrial environments and deformations of the basin infilling. The lithofacies-oriented sampling and statistical approach to the large dataset of AMS specimens were utilized to define 12 AMS facies based on anisotropy degree (P) and shape (T). The AMS facies allowed a distinction of sedimentary facies ambiguous for classical methods, especially floodplain and lacustrine sediments, as well as revealing their various vulnerabilities to tectonic modification of AMS. A spatial analysis of facies showed that tuffites along with lacustrine and swamp deposits were generally restricted to marginal and southern parts of the basin. Significant deformations were noticed at basin margins and within two intrabasinal tectonic zones, which indicated the tectonic activity of the Pieniny Klippen Belt after the Middle Miocene. The large southern area of the basin recorded consistent N-NE trending compression during basin inversion. This regional tectonic rearrangement resulted in a partial removal of the southernmost basin deposits and shaped the basin’s present-day extent.

Open access

Anna Lejzerowicz, Sebastian Kowalczyk and Anna Wysocka

Abstract

Ground-penetrating radar (GPR) surveys and sedimentological outcrop analyses were combined in order to determine the reflection patterns and internal architecture of terrace deposits of the Vistula River at Kępa Zawadowska in the southern part of Warsaw (central Poland). The sedimentary analyses concerned the granulometric composition and lithofacies analysis. The 34 GPR profiles, which were obtained in two outcrops, using a Malå RAMAC/GPR system with 500-MHz and 250-MHz shielded antennas, were up to 100 m long. The most characteristic ground-penetrating radar profiles are presented; they show a high-resolution data set of radar facies. The GPR data suggest the presence of three geophysically different units, namely with high-angle inclined reflections (radar facies 1), with discontinuous undulating or trough-shaped reflections (radar facies 2), and with low-angle reflections (radar facies 3). The internal structure of the fluvial deposits was obtained by integration of the GPR and sedimentological data, which combination provides a more accurate visualisation of sedimentary units than do reconstructions that are based only on standard lithologic point data.

Open access

Anna Snarska, Dominika Wysocka, Liliana Rytel, Sławomir Gonkowski, Hanna Pawelec and Przemysław Sobiech

Abstract

Introduction

Simvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other detriments to health may cause persistent muscle weakness, osteolytic processes, headaches, and rashes. Until now knowledge of the influence of simvastatin on bone marrow cells has been rather scant and fragmentary.

Material and Methods

During this experiment the numbers of all types of cells in the leukocytic system of porcine bone marrow were evaluated after 28 and 56 days of oral administration of simvastatin at a dose of 40 mg/day/animal.

Results

Simvastatin caused an increase in the number of all types of cells in the leukocytic system, and the most visible fluctuations concerned promyelocytes.

Conclusion

Observations obtained during the present study indicated that the results of the action of simvastatin on porcine bone marrow differ from those observed in other mammal species, including human. This may be due to various metabolic pathways within the bone marrow in the particular species, but the exact mechanisms of these actions are unknown at the present time.