In the near future, natural resources are very rapidly diminishing all over the globe. Which is very unhealthy for land ecosystem services. In the biodiversity, Tiger is an icon of healthy wildlife which is considered as a vital factor for maintaining Universal Food Chain System. This research paper is based on “Geo-Spatial Mapping of land use and land cover changes in the Core and Periphery Area of Ranthambore Tiger Reserve, Rajasthan, India, 1975-2015, it’s a micro level Study based on primary and secondary data through GIS mapping and consider as a Socio-Economic & Physical factors to inter-connect with Tiger habitats. Especially, core and periphery LULC have been obtained from the Multispectral images from ETM and ETM+ sensors of Landsat and LISS-III and AWiFS sensors of Resourcesat-satellites. This study examines the spatial and temporal patterns of LULC change along the boundary of Ranthambhore in the Rajasthan from 1975 to 2015. Tiger Landscape change within all ecological zones will be evaluated. The Landsat TM and ETM imagery will be used to produce LULC classification maps for both areas using a hybrid supervised/unsupervised methods. LULC changes are measured using landscape metrics and change maps created by post-classification through change detection. Using all the raster maps and the final change detection of the reserve will be done through spatial analysis using the raster calculator tool in ArcGIS and Erdas and MS Excel 13. The study comes out with land use and land cover change in core and periphery areas of the reserve. The research also describes Human Encroachment, Impact on human colonization, interfere with domestic animals, Interbreeding, and the Migration in core and periphery areas, finally, the situation would be alarming for biodiversity of tiger habitat due to the high pressure of anthropogenic activities.