We present a case of probably unreported aortic stenosis evolution in a patient with primary antiphospholipid syndrome (APS). A female patient, 54 years old, with a history of recurrent deep venous thrombosis, an episode of pulmonary embolism and was positive for APS antibodies. She was kept on warfarin and aspirin. The patient was admitted with acute pulmonary edema and severe aortic stenosis. While preparing for aortic valve surgery, the patient developed acute stroke, and a week later developed concurrent acute ischemia of both lower limbs. Emergency surgery salvaged the lower limbs and follow up transthoracic echocardiography showed marked regression of the thickening of the aortic valve leaflets, only mild aortic stenosis and moderate aortic regurgitation. Aortic valve surgery was cancelled, and the patient was kept on warfarin and aspirin.
Development of severe aortic stenosis is uncommon in primary APS, and this scenario of spontaneous improvement from a severe to a mild aortic stenosis, is probably unreported before.
Acute strenuous exercise can induce a state of oxidative stress affecting the involved muscles. Heptathlon is a multi-event exercise of two days duration and can be considered an acute, intensive endurance exercise. The purpose of this study is to compare the oxidative stress response to heptathlon events day by day and to determine the impact of this type of exercise on oxidative stress biomarkers.
The study subjects included eight heptathlon athletes who participated in the National First Class Republic competition in Egypt (October 19-21, 2011). Blood samples were collected at rest after exercise for two successive days and analyzed for malondialdehyde (MDA). Morning urine samples were collected one hour after exercise for each day and were analyzed for 8-hydroxydeoxyguanosine (8-OHdG). Results revealed a significant increase (p<0.05) in both plasma MDA and urine 8-OHdG levels after exercise regardless of the day. We concluded that exercise generates higher MDA levels compared to DNA strand breaks and oxidative DNA damage in athletes with antioxidant supplementation.
Youssef A. Attia, Mohammed A. Al-Harthi, Ali S. El-Shafey, Yassar A. Rehab and Woo Kyun Kim
Heat stress is one of the major challenges which the poultry industry faces during summer in tropical and subtropical regions. This study was conducted to evaluate the impact of Vitamin (Vit) E, C and/or probiotics on improving tolerance of broiler chickens to chronic heat stress (CHS). A total of 294, 1-day-old Cobb-500 broiler chicks were allocated into seven treatment groups; Thermoneutral group was raised under a thermoneutral condition during 25–42 d of age. The other six groups were raised for three successive days per week at 36±2ºC and 75–85% relative humidity for 7 h daily: heat stressed group, Vit E (100 mg/kg diet), Vit C (200 mg/kg diet), Vit C+Vit E, probiotics (Saccharomyces cerevisiae and Lactobacillus acidophilus at 2 g/kg diet) and Vit C+Vit E+probiotics. Exposure to CHS decreased body weight gain (BWG), feed intake (FI), and abdominal fat. It had adverse impact on feed conversion ratio (FCR), packed cell volume (PCV), monocyte, basophil, total protein, and phagocytic activity while increased plasma cholesterol and aspartate aminotransferase (AST) compared to the thermoneutral group. Vit E, Vit C or probiotics alone decreased the adverse effects of CHS on growth rate throughout the experimental period. Vit C and E were equally potent during the experimental period, but were less effective than the combination of both vitamins. Vit E increased the dressing percentage and abdominal fat as compared to the thermoneutral group, but decreased AST while increasing basophil, monocyte and globulin compared to the heat stressed group. In addition, serum albumin and AST of Vit E were lower compared to Vit C, but cholesterol was higher. Vit E increased red blood cells and white blood cells, but plasma cholesterol was increased compared with the heat stressed group. Vit C increased PCV, lymphocytes, monocyte, basophil and albumin and decreased neutrophil. Both vitamins without/with probiotic induced a further increase in basophil, serum total protein, and albumin. It could be concluded that supplementation of Vit E, Vit C, probiotics, and different combinations reduced some of the adverse effects of CHS, and Vit E+Vit C+probiotics was the most effective for economic traits followed by Vit E+Vit C or probiotics.
Osama Y Abdelfattah, Sabry Allam, Ismail Youssef, Mohammad Mourad and Ali El-Tawwab
Egyptian waste cooking oils have special specifications because it expose to high temperatures during use for long hours. In the present experimental study, the performance and emissions of a four strokes, single cylinder, air-cooled diesel engine fuelled with two different biodiesel from Egyptian used cooking oil (palm and sunflower) are evaluated at different speeds. The measured performance parameters include torque, fuel consumption and exhaust gas temperature. Brake power, brake specific fuel consumption and brake thermal efficiency was calculated using the measured test data The emission parameters include carbon monoxide, particulate matter and the oxides of nitrogen. The tests have been carried out with different blends of B5 to B100 of biodiesel with diesel fuel. The results showed that the cetane number of sunflower biodiesel has dropped significantly as a result of high temperatures and negatively affected the performance and emissions of the diesel engine also the engine performance with the palm biodiesel blend B5 is closed to diesel fuel also, for B5 CO emission decreased from 53 to 70% while NOx emission decreased from 13 to 80% compared to diesel fuel.