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  • Author: Alexandra Enache x
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Abstract

Background and Aims: This study’s aim was to evaluate the prevalence of obesity and new cases of diabetes in Roma population compared to ethnic Romanian Caucasians from Călăraşi County in the south part of Romania.

Material and Methods: The population included in this study is part of a larger project that aims to evaluate the prevalence of obesity, prediabetes and diabetes in the Roma population from Călăraşi County. So far we have included 344 people: 180 Roma (119 female/61 male), and 164 non-Roma (108 female/56 male) aged between 18 and 85.

Results: In Roma population, the prevalence of underweight, normal weight, overweight and obesity was 4.4% (n=8), 37.2% (n=67), 26.7% (n=48) and 31.7% (n=57) respectively. In Romanian Caucasians, the prevalence of overweight and obesity was 37.2% (n=61) and 32.3% (n=53) respectively. Diabetes was diagnosed in 14.6% (n=24) of Romanian Caucasians and in 11.7% (n=21) of Roma population. Risk factors for obesity in Roma population were: lower socio-educational level, smoking, physical inactivity (active less than 30 min/day).

Conclusions: High prevalence of overweight (26.7%), obesity (31.7%) and new cases of diabetes (11.7%) among the Roma population in the south part of Romania, Calarasi County was an important finding of our study. We observed a negative effect of lifestyle behaviours on health-related outcomes: smoking, sedentariness, lower socio-educational level.

Abstract

Introduction. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin, characterized by multisystemic involvement and a potentially severe evolution. Pulmonary arterial hypertension (PAH) is a rare complication of SLE, with low 5-year survival.

Case presentation. We are presenting the case of a female patient, aged 56 years old, diagnosed in 1992 with SLE with cutaneous manifestations (butterfly-shaped erythematous rash), joint manifestations (polyarthritis), serositis manifestations (massive pleuropericarditis), and immunological manifestations (positive anti-dsDNA antibodies, decreased C3), ignored therapeutically for a long time. In 2010 she complained of dyspnea on medium exertion and leg edemas, with marked increase of PAPs by echocardiography. She was diagnosed with severe PAH (confirmed by right heart catheterization) and in the “Marius Nasta” National Institute of Pneumology she started a treatment with an endothelin receptor antagonist (Bosentan) in combination with a prostacyclin receptor agonist (Selexipag). Since 2013 the patient is on oral anticoagulant treatment for permanent atrial fibrillation.

In 2015 she was referred back to out clinic as she complained of recurrent episodes of massive ascites with evacuatory paracenteses in amounts of about 6-9L per paracentesis. After excluding other causes, ascites was considered to be secondary to the SLE, and a treatment was initiated with Hydroxychloroquine (HCQ) and pulse therapy with Methylprednisolone, on which the remission of the ascites was achieved during the following months. Currently, the SLE is well controlled without recurrence of ascites on treatment with HCQ and gradual decrease until stopping of cortisone doses, and the PAH is stable.

Conclusion. PAH is a rare complication of the SLE, with a complex pathophysiological immune mechanism, for which - together with the specific vasodilator treatment - the increase of immune suppression is recommended.

Abstract

The current practice in the field of forensic medicine imposes the use of modern investigation techniques. The complexity of laboratory investigation methods needed for a final result of the investigation in forensic medicine needed new biomarkers of higher specificity and selectivity. Such biomarkers are the microRNAs (miRNAs), short, non-coding RNAs composed of 19–24 nucleotides. Their characteristics, such as high stability, selectivity, and specificity for biological fluids, differ from tissue to tissue and for certain pathologies, turning them into the ideal candidate for laboratory techniques used in forensic medicine. In this paper, we wish to highlight the biochemical properties and the usefulness of miRNAs in forensic medicine.