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Adrian Popovici, Cornel Ilinca and Cristian Anghel

Abstract

The sectional stresses (M, N) in a gallery lining are computed comparatively numerical by FEM taking into account the interaction underground structure - surrounding ground and analytical by Protodiakonov method. The last method is based on coincidence arch born in ground over gallery.

Comprehensive analyses allow to settle the domain in which Protodiakonov method can be applied as well as the conditions in which discharge arches appear in ground above underground or embedded structures.

The study is available for galleries (tunnels) built so that their lining takes loads from undeformed ground (rock) mass surrounding gallery, existent before excavation.

Open access

Cornel Ilinca, Răzvan Vârvorea and Adrian Popovici

Abstract

The seismic analysis of a buttress dam with 73.50 m height is performed by the spectral analysis method and the direct time integration method. An accelerogram with 0.1g maximum acceleration was applied horizontally, in the upstream - downstream direction, at the bottom of the dam-foundation finite element mesh. The hydrodynamic effect of the reservoir was considered according to the added mass procedure (Westergaard relation). ABAQUS software was used to make the analyses. The same type of finite element C3D20R was used for the mesh of the dam body and of the foundation. The comparison of the results is made on the displacements, the stress state and the sliding stability on the dam-foundation contact in the full reservoir hypothesis. The comprehensive analysis concluded that both methods had provided close results for the considered case study. The spectral analysis method revealed itself to be more conservative compared to the direct time integration method.

Open access

Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Sonia Elena Popovici, Adriana Mariana Sas, Adrian Tudor Stan, Emil Robert Stoicescu and Dorel Sandesc

Abstract

Cardiovascular disease is a leading cause of death globally. At present, there are many ways to diagnose this pathophysiology. The greatest disadvantages related to current biomarkers are their low specificity, low selectivity and low accuracy. A new method, extensively studied recently, is the expression of miRNAs, used as genetic biomarkers for the early diagnosis of cardiovascular diseases. This paper presents an update of miRNAs species expression that can serve as early diagnostic biomarkers and for the continuous monitoring of patients with cardiovascular disease.

Open access

Raluca Dumache, Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Veronica Ciocan, Camelia Muresan, Adrian Tudor Stan, Mihai Sandesc, Anca Dinu, Sonia Elena Popovici and Alexandra Enache

Abstract

The current practice in the field of forensic medicine imposes the use of modern investigation techniques. The complexity of laboratory investigation methods needed for a final result of the investigation in forensic medicine needed new biomarkers of higher specificity and selectivity. Such biomarkers are the microRNAs (miRNAs), short, non-coding RNAs composed of 19–24 nucleotides. Their characteristics, such as high stability, selectivity, and specificity for biological fluids, differ from tissue to tissue and for certain pathologies, turning them into the ideal candidate for laboratory techniques used in forensic medicine. In this paper, we wish to highlight the biochemical properties and the usefulness of miRNAs in forensic medicine.