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Constantin Streche, Adrian Badea, Irina A. Istrate, Diana M. Cocârţă and Tiberiu Apostol

Abstract

In 2011, as a result of the inventory conducted at the national level, The Ministry Of Environment concluded that the largest number of contaminated sites with hydrocarbons are due to the petroleum products distribution (nearly 400 sites), followed by the hydrocarbons extraction (about 310 sites). So, soil contamination with liquid petroleum products resulting from many industrial activities became an important issue of environment protection. Unfortunately not all local governments have provided a list of contaminated sites, which means that there is a possibility to have a bigger problem at the national level. All these surfaces are in a continuous growth due to industrial and social development and that is why it is necessary to study and improve decontamination methods of contaminated sites in order to regain one of our most important resources - the soil. In this paper, the main results obtained during a research that aimed to study two different treatment methods of contaminated soil in a combined solution, are presented. The newly developed method is called electro-flushing. Results proved that combining the two nominated methods could be a viable solution for treating diesel polluted soil with better performances comparing with using them separately. Concerning the electrochemical treatment of diesel contaminated soils an efficiency of 35-40 % could be obtained after 28 days; while using the flushing method up to 15-20% efficiency could be reached. On the other hand, if we combine these two methods, we can reach remediation efficiency up to 50%. So, the main interesting results of the present research is given by the fact that combining two known remediation methods, better performances could be achieved.

Open access

Mihail Alexandru Badea, Florin Buicu, Anton Mihai Ţilea, Iudita Maria Badea, Andreea Luciana Chiotoroiu, Vasile Adrian Mureșan and Silviu Horia Morariu

Abstract

Graham Little-Lassueur Syndrome (GLLS) is considered a form of lichen planopilaris which associates follicular lichen planus, cicatricial alopecia of the scalp and noncicatricial alopecia of the axillary and/or pubic regions. We present the case of a 47 years old female patient, known for 5 years with chronic hepatitis C and a poor therapeutic control of the disease due to Interferon intolerance. She presented to our clinic for the occurrence on the shins of some well-defined, intensely pruritic erythematous plaques, covered with thick scales, with a verrucous appearance, accompanied by excoriations. The skin biopsy reveal hypertrophic lichen planus on the shins and lichen planopilaris on the scalp. The patient was treated with systemic antihystamines, topical corticosteroids and salicylic acid under occlusion, emollients, phototherapy UVB narrow band 4 sessions/week for 3 weeks, cryotherapy. From our knowledge this is the first case of GLLS associated with chronic viral hepatis C.

Open access

Grigorescu Bianca, Fodor Raluca, Mihaly Veres, Monica Orlandea, Judita Badea, Katalin Hlavathy and Adrian Cioc

Abstract

Introduction: NGAL (Neutrophil Gelatinase Associated Lipocalin) is a biomarker recently introduced into clinical practice for the early diagnosis of acute kidney injury (AKI). The aim of this study was to correlate the plasmatic NGAL value determined at admission with clinical progression and severity of AKI in critically ill patients.

Material and method: Thirty two consecutive critically ill adult patients at risk of developing AKI (trauma, sepsis), admitted in Intensive Care Unit of the Clinical County Emergency Hospital Mures, between January to March 2015 were enrolled in the study. For each patient included in the study plasma NGAL levels were determined on admission, and these were correlated with the degree of AKI development (according to AKIN criteria) at 48 hours and 5 days post admission. The discriminatory power of NGAL, creatinine, creatinine clearance and corrected creatinine (depending on water balance) were determined using the ROC (receiver-operating characteristic) and likelihood ratios.

Results: ROC curve analysis showed a better discriminatory capacity in terms of early diagnosis of AKI for NGAL (AUC=0.81 for NGAL, AUC=0.59 for creatinine, AUC=0.62 for corrected creatinine, AUC=0.29 for creatinine clearance). The value of likelihood ratio was also significantly higher for NGAL (3.01±2.73 for NGAL, 1.27±1.14 for creatinine, 1.78±1.81 for corrected creatinine, and 0.48±0.33 for creatinine clearance).

Conclusions: NGAL biomarker has a better discrimination capacity for early prediction of acute kidney injury compared to previously used markers.

Open access

Grigorescu Bianca-Liana, Fodor Raluca Ştefania, Scridon Alina, Perian Marcel, Badea Iudita, Cioc Adrian Dan, Cotoi Ovidiu Simion, Copotoiu Sanda-Maria and Azamfirei Leonard

Abstract

Objective: The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the hind limbs in healthy versus diabetic ischemic preconditioned rats.

Method: The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic preconditioned group. Acute ischemia was induced, followed by reperfusion. The assessment of reperfusion injury used biochemical, histopathological and functional determinations (peak tetanic tension-PTT, specific tension-ST).

Results: Ischemia-reperfusion injury was more severe in control group regarding creatine-kinase (CK) (CK1=470.13 IU/L versus CK2=230.88 IU/L, p=0.0001) and myoglobin (390.25 ng/mL versus 47.99 ng/mL, p=0.025). Cytolysis enzymes were significantly increased in diabetic preconditioned rats (Alanine aminotransferase ALAT1=46 IU/L, ALAT2=167.8 IU/L, p=0.02; Aspartate aminotransferase ASAT1=106 IU/L, ASAT2=237.5 IU/L, p=0.016). Functional assessment (PTT and ST) highlighted roughly equal values. A paradoxical response occurred in diabetic rats (the contractile force increased during the period of the stimulation). Histopathological findings showed that rhabdomyolysis was more severe in the control group, while inflammatory systemic response due to reperfusion injury was less expressed in diabetic ischemic preconditioned rats.

Conclusions: Ischemic preconditioning reduces the severity of reperfusion injury and allows the preservation of contractile muscle function in diabetic rats.

Open access

Caterina Delcea, Camelia Badea, Ciprian Jurcut, Adrian Purcarea, Silvia Sovaila, Emma Weiss, Elena Alistar, Horia Balan and Cristian Baicus

Abstract

Quality of care in medicine is not necessarily proportional to quantity of care and excess is often useless or even more, potentially detrimental to our patients. Adhering to the European Federation of Internal Medicine’s initiative, the Romanian Society of Internal Medicine (SRMI) launched the Choosing Wisely in Internal Medicine Campaign, aiming to cut down diagnostic procedures or therapeutics overused in our country. A Working Group was formed and from 200 published recommendations from previous international campaigns, 36 were voted as most important. These were submitted for voting to the members of the SRMI and posted on a social media platform. After the two voting rounds, the top six recommendations were established.