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Open access

I. Ganchev, S. Ahmed, A. Taneva and M. Petrov

Abstract

This paper presents a fuzzy-neural structure of a Decoupling Fuzzy PID controller with self-tuning parameters. This structure is appropriate for Two-Input-Two-Output (TITO) nonlinear system. The main advantage here is that the equation of classical PID control and decoupling coefficients are used as a Sugeno function into the fuzzy rules. Hence the designed decoupling fuzzy PID controller can be viewed as a natural similarity to the conventional one with decoupling elements. A benchmark quadruple tank, implementing a TITO nonlinear system is considered to illustrate the benefits of the design paradigm. The performance of this set up was studied for reference tracking and disturbance rejection cases. Simulation results confirm the effectiveness of the proposed solution.

Open access

Regina Komsa-Penkova, Svetla J. Todinova, Tonya D. Andreeva, Sashka B. Krumova, Stefka G. Taneva, Georgi M. Golemanov, Galia A. Georgieva, Nikolina M. Mihaylova, Andrey I. Tchorbanov and Pencho T. Tonchev

Summary

Platelet activation is a complex process in which platelet reorganization takes place associated with changes in the cell shape, topology, membrane elasticity and microparticle production. The aim of this study was to investigate the changes/aberrations in the platelet activity, elasticity and morphology in healthy subjects, carriers of A allele of prothrombin G20210A polymorphism. Blood samples from 18 healthy subjects were used for platelet analysis by force-mode atomic force microscopy. Restriction analysis was used to investigate the carriage of G20210A polymorphism in the prothrombin gene. Flow- cytometry was applied to evaluate platelet activation. Young’s modulus of the plasma membranes of platelets derived from healthy subjects, carriers of variant A allele of prothrombin 20210G>A polymorphism (407±69 kPa) is two times higher than the one determined for non­carriers (195.4±48.7 kPa; p<0.05). The background activity of platelets measured as an interrelation of Cd41/Cd61 and CD62 by flow cytometry was also higher in carriers of variant A allele of prothrombin 20210G>A polymorphism (5.0%) than in non-carriers (1.3%). Platelets isolated from healthy carriers of variant A allele of prothrombin 20210G>A polymorphism exhibited a higher level of activity and a higher degree of stiffness at the stage of spreading as compared to platelets from non­carriers.