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A. Roguska, A. Belcarz, P. Suchecki, M. Andrzejczuk and M. Lewandowska

Abstract

Problem of post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO2 NT and ZnO/TiO2 NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO2 NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

Open access

A. Roguska, A. Belcarz, P. Suchecki, M. Andrzejczuk and M. Lewandowska

Problem of Post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO2 NT and ZnO/TiO2 NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO2 NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

Open access

M. Pisarek, A. Roguska, L. Marcon, M. Andrzejczuk and M. Janik-Czachor

The main requirements for titanium biomaterials are: (a) biocompatibility, (b) resistance to biological corrosion and (c) antisepticity. These requirements may be met by a new generation of titanium biomaterials with a specific surface layer of strictly defined microstructure, chemical and phase composition. Recently, various surface modifications have been applied to form a bioactive layer on Ti surface, which is known to accelerate osseointegration.

The purpose of this study was to investigate bioactivity of porous calcium phosphate coatings prepared by a direct electrodeposition on Ti surface from a modified Hanks’ solution. The thick 200 nm coatings, were prepared via cathodic polarization at constant voltage -1.5 V vs. OCP in a Hanks’ solution. In order to evaluate the potential use of the coatings for biomedical applications, the adsorption of bovine serum albumin (BSA), the most abundant protein in blood, and living cells attachment (osteoblasts, U2OS) were studied. The observed differences in living cells attachment suggest a more promising initial cellular response of Ca-P coatings with a pre-adsorbed albumin.

The topography and a cross-section view of the Ca-P coatings were characterized using SEM and STEM techniques. The surface analytical techniques (AES, XPS, and FTIR) were used to characterize their chemical composition before and after protein BSA adsorption.

Open access

T. Wierzchoń, E. Czarnowska, J. Morgiel, A. Sowińska, M. Tarnowski and A. Roguska

Abstract

Diffusion nitrided layers produced on titanium and its alloys are widely studied in terms of their application for cardiac and bone implants. The influence of the structure, the phase composition, topography and surface morphology on their biological properties is being investigated. The article presents the results of a study of the topography (nanotopography) of the surface of TiN+Ti2N+αTi(N) nitrided layers produced in low-temperature plasma on Ti6Al4V titanium alloy and their influence on the adhesion of blood platelets and their aggregates. The TEM microstructure of the produced layers have been examined and it was demonstrated that the interaction between platelets and the surface of the titanium implants subjected to glow-discharge nitriding can be shaped via modification of the roughness parameters of the external layer of the TiN titanium nitride nanocrystalline zone.