Anisakidosis is a zoonotic infection caused by ingestion of raw or undercooked marine fish including Atherina. In some parts of Egypt, the prevalence of anisakid larvae in marine Atherina still, largely, undetermined. Moreover, the currently used procedures are insufficient to avoid human infection. The aim of this study was to identify the prevalence of anisakid larvae in marine Atherina and to test the effect of several treatment procedures on the viability of anisakid larvae. The infection rate of marine Atherina with anisakid larvae was 23.12 %. Anisakid larvae protein revealed molecular weights ranged from 11.5 - 118.5 Kilo Dalton (KDa.). Moreover, freezing at -20 °C for 21 hours (hrs.) as well as vinegar (5 %) treatment for 3 days were the most effective ways to inactivate the larvae. This study states the zoonotic risk of consuming raw or undercooked marine Atherina and highlights the importance of freezing and vinegar treatment in preventing human infection.
Hyperparathyroidism-Jaw Tumor (HPT-JT) is an autosomal dominant disorder with variable expression, with an estimated prevalence of 6.7 per 1,000 population. Genetic testing for predisposing CDC73 (HRPT2) mutations has been an important clinical advance, aimed at early detection and/or treatment to prevent advanced disease. The aim of this study is to assess the most deleterious SNPs mutations on CDC73 gene and to predict their influence on the functional and structural levels using different bioinformatics tools. Method: Computational analysis using twelve different in-silico tools including SIFT, PROVEAN, PolyPhen-2, SNAP2, PhD-SNP, SNPs&GO, P-Mut, I-Mutant ,Project Hope, Chimera, COSMIC and dbSNP Short Genetic Variations were used to identify the impact of mutations in CDC73 gene that might be causing jaw tumor. Results: From (733) SNPs identified in the CDC73 gene we found that only Eleven SNPs (G49C, L63P, L64P, D90H, R222G, W231R, P360S, R441C, R441H, R504S and R504H) has deleterious effect on the function and structure of protein and expected to cause the syndrome. Conclusion: Eleven substantial genetic/molecular aberrations in CDC73 gene identified that could serve as diagnostic markers for hyperparathyroidism-jaw tumor (HPT-JT).
This work investigates the effects of radiation and Eckert number on an MHD flow with heat transfer rate near a stagnation-point region over a nonlinear vertical stretching sheet. Using a similarity transformation, the governing equations are transformed into a system of ordinary differential equations which are solved numerically using the sixth order Runge-Kutta method with shooting technique. Tabular and graphical results are provided to examine the physical nature of the problem. Heat transfer rate at the surface decreases with radiation, Eckert number and as radiation increases, the flow temperature also increases for velocity ratio parameters ɛ <1 and ɛ >1.
This work investigates the mixed convection in a Magnetohydrodynamic (MHD) flow and heat transfer rate near a stagnation-point region over a nonlinear vertical stretching sheet. Using a similarity transformation, the governing equations are transformed into a system of ordinary differential equations which are solved numerically using the fourth order Runge-Kutta method with shooting technique. The influence of pertinent flow parameters on velocity, temperature, surface drag force and heat transfer rate are computed and analyzed. Graphical and tabular results are given to examine the nature of the problem. The heat transfer rate at the surface increases with the mixed convection.