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  • Author: Ştefania Crăiţoiu x
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Marius Cristian Neamţu, Ştefania Crăiţoiu, Rucsandra Dănciulescu Miulescu and Denisa Margină

Abstract

Background and Aims. Previous studies have shown that hypochromia is a common finding in patients with chronic diseases. The aim of our study was to estimate the anthropometric and metabolic characteristics of patients with type 2 diabetes mellitus (T2DM) and hypochromia. Material and Methods. 30 patients with T2DM were recruited for this study. Patient demographics, relevant concomitant illnesses and medical history were recorded. Anthropometric, biochemical parameters (fasting plasma glucose - FPG, glycated hemoglobin -HbA1c, glomerular filtration rate - GFR) and morphology of blood smear were assessed. Patients diagnosed with diabetes and hypochromia constituted the study group and patients with type T2DM but without hypochromia constituted the control group. Results. The study showed no statistically significant differences on anthropometric and metabolic characteristics of patients with diabetes and hypochromia, compared with controls. Conclusions. We observed a high prevalence of hypochromia in diabetic patients (46.66%). Our findings suggest the need of screening for routine hematological tests in patients with T2DM.

Open access

Alina Bădescu, Claudia Valentina Georgescu, Claudiu Mărgăritescu, Daniela Cernea, Maria Bălăşoiu, Ştefania Crăiţoiu and Corneliu Cristian Georgescu

Abstract

Aim: Our objective in conducting this study was to estimate the presence of lymphatic, blood vessel and neural invasion on Hematoxylin & Eosin (H&E) staining and also, the microvessel density detected by immunohistochemistry (MVD), in gastric adenocarcinoma, as well as their relationship with the clinical, pathological and biological characteristics of the tumors. Materials and Methods: To assess the vascular and neural invasion in our study, we included 367 patients diagnosed with gastric cancer. For the immunohistochemical study of MVD, from all cases with gastric carcinoma, we selected 28 patients, 12 patients with gastric biopsy and 16 patients with total gastric resection, which established the TNM stage. All the gastric biopsies and surgical samples were prepared using the paraffin-embedding method and H&E staining and using anti-CD31 and anti-CD34 antibodies for the assessment of intratumoral MVD. Results: The positive blood vessel invasion was associated in a significant way with advanced stages (p <0.01) and high grade carcinomas (p<0.01), while lymphatic invasion was very significant associated only with advanced stage tumors (p < 0.001). Regarding peri- and intraneural invasion, there was a significant matching with the female gender (p < 0.05), advanced stages of disease (p < 0.001), the diffuse type of gastric carcinoma (p <0.05), and with poorly differentiated tumors (p<0.05). There was a close relationship between CD34 MVD and the diffuse type of gastric carcinomas, according to Lauren’s classification (p<0.05), and poorly differentiated tumors (p<0.05). The CD34 MVD values mean was significant correlated with TNM stage, especially III and IV stages (p<0.01). Conclusions: Blood vessel invasion, neural invasion and CD34 MVD play a significant role in tumors biological behavior and they can be used as important prognostic parameters which describes the aggressiveness of gastric carcinomas.