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Open access

Łukasz Jeleń, Thomas Fevens and Adam Krzyżak

Classification of Breast Cancer Malignancy Using Cytological Images of Fine Needle Aspiration Biopsies

According to the World Health Organization (WHO), breast cancer (BC) is one of the most deadly cancers diagnosed among middle-aged women. Precise diagnosis and prognosis are crucial to reduce the high death rate. In this paper we present a framework for automatic malignancy grading of fine needle aspiration biopsy tissue. The malignancy grade is one of the most important factors taken into consideration during the prediction of cancer behavior after the treatment. Our framework is based on a classification using Support Vector Machines (SVM). The SVMs presented here are able to assign a malignancy grade based on preextracted features with the accuracy up to 94.24%. We also show that SVMs performed best out of four tested classifiers.

Open access

Tomasz Bruździński, Adam Krzyżak, Thomas Fevens and Łukasz Jeleń

Abstract

The aim of this work is to create a web-based system that will assist its users in the cancer diagnosis process by means of automatic classification of cytological images obtained during fine needle aspiration biopsy. This paper contains a description of the study on the quality of the various algorithms used for the segmentation and classification of breast cancer malignancy. The object of the study is to classify the degree of malignancy of breast cancer cases from fine needle aspiration biopsy images into one of the two classes of malignancy, high or intermediate. For that purpose we have compared 3 segmentation methods: k-means, fuzzy c-means and watershed, and based on these segmentations we have constructed a 25–element feature vector. The feature vector was introduced as an input to 8 classifiers and their accuracy was checked.

The results show that the highest classification accuracy of 89.02 % was recorded for the multilayer perceptron. Fuzzy c–means proved to be the most accurate segmentation algorithm, but at the same time it is the most computationally intensive among the three studied segmentation methods.