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  • Author: Romuald Olszański x
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Open access

Piotr Siermontowski, Agnieszka Pedrycz, Maciej Konarski, Dorota Kaczerska, Katarzyna van Damme-Ostapowicz, Romuald Olszański and Zbigniew Boratyński

Abstract

The aim of the study was to examine the effects of hyperbaric oxygen on lung aeration on an animal experimental model and compare the obtained results with the anticipated scope of damage to pulmonary parenchyma in humans under the same exposure conditions. The research was carried out on Black Hood rats that were kept in a hyperbaric chamber designed for animals in an atmosphere of pure oxygen and at overpressures of 0.15, 0.2, 0.3, 0.4, and 0.5 MPa for 1, 2 or 4 h. After sacrificing the animals, histopathological specimens were obtained encompassing cross-sections of entire lungs, which were subjected to qualitative and quantitative examination with the use of the 121-point Haug grid. A statistically significant decrease in pulmonary parenchyma was observed as a result of an increasing oxygen partial pressure as well as with prolonged exposure time. The intensification of changes observed was much higher than expected on the basis of calculations performed with the use of tables.

Open access

Piotr Siermontowski, Dorota Kaczerska, Bartosz Morawiec, Agnieszka Pedrycz, Adam Olejnik, Romuald Olszański and Zbigniew Boratyński

Abstract

The aim of the presented study was to determine whether pulmonary barotrauma without pneumothorax affects the parameters of acid-base balance. The experiment was conducted on rabbits divided into experimental and control groups. The animals from the experimental group were subjected to compression in the hyperbaric chamber and pulmonary barotrauma was induced using a method developed by authors. The arterial blood was sampled before the experiment, after anaesthesia and intubation, after injury, and after treatment (in the group undergoing hyperbaric therapy). All parameters of acid-base balance were found to be within the reference ranges. Since the biggest changes were observed after anaesthesia and intubation and not after the injury, it was concluded that pulmonary barotrauma had no significant effect on the parameters of acid-base balance.