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  • Author: Li-Chun Zhang x
  • Molecular Biology x
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Chun Xie, Yi-Xuan Hou, Yu-Ting Zhao, Xue-Hui Cai, Cai-Ying Li, Pei-Feng Li, Yun-Zhang Li, Xue Su, Xiu-Wei Yue, Shu-Jie Wang, Yong-Gang Liu, Wei-Jun Yang, Cong-Li Yuan, Li Cu, Xiu-Guo Hua and Zhi-Biao Yang


Five pathogen-free miniature pigs (minipigs) were infected with the virulent strain SH08 of Streptococcus suis 2 (SS2) by intramuscular injection. The pigs died consecutively within 72 h after the challenge. An additional five non-infected pigs were euthanised and used as controls. Microstructural observations showed that degeneration, bleeding, congestion, cellular necrosis, and an increase in inflammatory cells were present in all organs and tissues except the brain. Ultrastructural observations revealed mitochondrial vacuolation and malformed or missing cristae, indicating that infection of minipigs with strain SH08 of SS2 can lead to extensive lesions in major internal organs and tissues. The findings also demonstrated that the minipig is a useful model for the study of SS2 infection.