The article is devoted to the territorial organization of the manufacturing industry during its transformation from an industrial to a post-industrial phase of development - as one of the most urgent issues of economic geography at the turn of the 21st century. This period was characterized by the acceleration of human output beyond the industrial system and by the regrouping of its driving forces. Post-industrial development of developed countries in many respects determined the changes in the sectorial, institutional and spatial structures of the global industry. At the same time, industrialization acceleration occurred in developing countries, including at the expense of the “transfer” of productions in a number of industries from more developed countries. This article analyses the changes in the distribution of the manufacturing industry on a global and regional level.