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  • Author: Ciprian Dina x
  • Endocrinology, Diabetology x
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Open access

Raluca Dina, Iulia Vladu, Ciprian Dina and Adina Mitrea

Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

Background and Aim: Skin autofluorescence (AF) is a method used to detect the accumulation of Advanced Glycation End Products (AGEs) in skin collagen using AGE Reader. AGEs accumulation is favorised by chronic hyperglycemia and oxidative stress and these products may contribute to the pathogenesis of cardiovascular disease. Materials and Methods. The inclusion criteria for the study were: patients with Body Mass Index (BMI) ≥30kg/m2. We excluded from the study patients of black color, because of the principle of fluorescence of AGE Reader, and also patients with diabetes. Patients underwent Oral Glucose Tolerance Test (OGTT) with 75g of glucose: fasting plasma glucose (FPG), two hours post glucose load, and HbA1c blood samples were analysed. Finnish diabetes risk score for predicting the incidence of diabetes (FINDRISK score) was calculated. Results. BMI had a negative correlation with AF (p<0.005), but Abdominal Circumference (AC) was not correlated with AF (p=0.065). No correlations were found between BMI and FPG, or blood sugar level two hour post glucose load. Glucose level at two hours post glucose load did not correlate with the AF. Conclusion. Our results do not confirm the theoretical assumption according to which AC and BMI, as markers of insulin resistance and metabolic disorders, are associated with the increase in AGEs, or the assumption that postprandial blood glucose levels would have a more important role in the development of chronic complications that AGEs could be pathogenic link. AF is not influenced by short-term variations in blood glucose such as blood sugar level at two hours post glucose load, but it is influenced by FPG and prolonged term variation in blood glucose as HbA1c.

Open access

Raluca Costina Dina, Maria Moţa, Iulia Vladu and Ciprian A. Dina


Introduction.Hepatic steatosis is a reversible condition caused by accumulation of triglycerides in liver cells. Non-alcoholic fatty liver disease (NAFLD) can progress to advanced liver disease: fibrosis, cirrhosis, liver failure, cancer, and finally can lead to death; therefore NAFLD contributes significantly to morbidity and mortality of hepatic cause. Materials and methods: The study was conducted on a group of 88 patients with Body Mass Index (BMI) ≥ 30kg/m², they were excluded patients with known diabetes. Results, Discussion: The statistical analysis showed that in more than half of subjects elastometry values were higher than those considered normal, obesity is a risk factor for NAFLD that progresses in hepatic fibrosis. Conclusions: Liver fibrosis is present in high percentage in patients with obesity (52% of subjects) and it was positively correlated with age, arterial stiffness and fasting glucose.

Open access

Ciprian A. Dina, Maria Iancau, Maria Moţa, Raluca Costina Dina and Iulia Vladu


Periodontitis is a common complication in patients with diabetes. Their classification is complex and it is based on the clinical presentation, rate of disease progression, age at diagnosis and local and systemic factors that may multiply the risk. The two major stages of periodontal diseases are gingivitis and periodontitis. The relationship between these two diseases appears bidirectional insofar that the existence of one disease tends to promote the other and that the meticulous management of either may help the treatment of the other. Treatment of periodontitis using a association of mechanical therapy, scaling and root planning, plus systemic tetracycline antibiotics has been demonstrated to have important reductions in HbA1c values. Therefore, for a better control of diabetes we suggest that periodontal patients with diabetes should be consulted and treated by a periodontist.

Open access

Iulia-Daniela Vladu, Daniela Cana, Cristina Vaduva, Corina Grauntanu, Sorin Zaharie, Raluca Dina, Ciprian Dina, Roxana Mustafa and Eugen Mota

Chronic Kidney Disease-Mineral Bone Disorder in Diabetes Mellitus Patients

Diabetes mellitus (DM) and chronic kidney disease (CKD) are two diseases with increasing prevalence and adverse outcomes that represent an international health problem. Chronic kidney disease- mineral and bone disorder (CKD-MBD) is defined as a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; abnormalities in bone turnover, mineralization, volume, linear growth, or strength and vascular or other soft-tissue calcification. Disturbances in mineral and bone metabolism are prevalent in CKD and are an important cause of decreased quality of life, cardiovascular morbidity and mortality; these disturbances settle in earlier and have a more severe evolution in DM patients.