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Bogdan Mircea Mihai, Didona Anca Ungureanu, Antoniu Octavian Petriş and Cristina Mihaela Lăcătuşu

Abstract

Background and Aims: Prediabetes, a category of incipient hyperglycemia that includes impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT), has an increasing incidence in the modern world. We searched for differences in anthropometric and metabolic characteristics between subjects with isolated IFG and IFG+IGT. Material

and Methods: In our cross-sectional study, 154 subjects with IFG and IFG+IGT, without any other major pathologies, were analyzed. Anthropometric data, lipid profile, uric acid, insulin resistance indexes, adiponectin, leptin and leptin-to-adiponectin ratio were compared. Results: Only 122 subjects (64 with isolated IFG and 58 with IFG+IGT), without any other identifiable major disease, were included in the final analysis. Most characteristics of the two groups were similar, only minor differences in anthropometric data, biochemical profile and insulin resistance indexes being noted. Insulin resistance indexes were stronger associated with adiponectin in the group with isolated IFG and with leptin and leptin-to-adiponectin ratio in the IFG+IGT group. Conclusions: Our data suggest a similar anthropometric and metabolic profile in subjects with isolated IFG and with IFG+IGT. In isolated IFG, insulin resistance seems to correlate better with adiponectin, while in IFG+IGT it seems to associate mostly with leptin and derived parameters

Open access

Bogdan-Mircea Mihai, Cristina Mihaela Lăcătuşu, Elena-Daniela Grigorescu and Gina Eosefina Botnariu

Open access

Bogdan-Mircea Mihai, Cristina Mihaela Lăcătuşu, Elena-Daniela Grigorescu and Gina Eosefina Botnariu

Open access

Elena-Daniela Grigorescu, Cristina Mihaela Lăcătuşu, Gina Eosefina Botnariu, Raluca Maria Popescu, Alina Delia Popa, Alina Onofriescu and Bogdan-Mircea Mihai

Abstract

The physician-patient communication has an essential role in establishing and supporting the relationship between these two partners. Moreover, modern medicine highlights the patient-centered approach. Publications assessing the impact of an efficient physicianpatient communication on medical care results in diseases such as diabetes and hypertension have revealed a positive correlation between patient’s satisfaction about the communication with the physician and values of blood pressure, glycated hemoglobin and pain intensity. Interventions needed in both doctors and patients for developing communication abilities were paid special attention in order to achieve an appropriate improvement in their communicative interaction during periodical appointments. In the field of diabetes mellitus, the medical challenge is to improve patients’ knowledge about medical care; this aim is achieved only by therapeutic education, using high-quality communication techniques.

Open access

Vlad Pădureanu, Anca Ştefania Enescu, Isabela Siloşi, Maria Forţofoiu, Aurelia Enescu, Maria Bogdan, Mircea Cătălin Forţofoiu, Amelia Genunche Dumitrescu, Diana Rodica Tudoraşcu, Adrian Mita, Ioana Streata, Mihai Ioana, Florin Petrescu and Adrian Săftoiu

Abstract

Introduction. Chronic pancreatitis is morphologically characterized by ductal dysplasia, breeding grounds for the proliferation of the ductal cells, the degenerative changes in pancreatic acinar cells and fibrosis, and it is defined on the basis of the clinical, morphological and functional criteria.

Aim. The aim of our study is to examine the existence of a possible correlation between the iNOS-2087A>G polymorphism and chronic pancreatitis by means of the genetic analysis.

Material and method. We have conducted the study at the Gastroenterology Clinic and the Research Center of Gastroenterology and Hepatology of the University of Medicine and Pharmacy, Craiova, between March 2015 – September 2016. The study had a prospective character. Both for the 58 patients diagnosed with chronic pancreatitis and for the 132 patients in the witness group, the biological material was represented by blood, (around 2.5 – 5 milliliters of venous blood) let on EDTA and kept at 4°C up to the separation of the DNA molecule. All the patients were genotyped for the iNOS – 2087A>G polymorphism, by means of the Real Time PCR technique with TaqMan probes.

Results. Analysing the prevalence of the iNOS genotypes within the study group and witness group, we have noticed that, statistically speaking, there are no significant differences between the two groups.

Conclusion. As a conclusion, in the study lot we can sustain that the risk of developing chronic pancreatitis is not increased by the presence of the iNOS-2087A>G polymorphism.