Background and aims: Diabetes is considered as the most prevalent disease due to metabolic disorders. This study aimed to determine the effect of an educational on the quality of life) QOL( in patients with type 2 diabetes mellitus (T2DM ). Material and methods: This quasi-experimental study was conducted in the form of a pre-test/post-test with intervention. The statistical sample of this study included 70 patients with type 2 diabetes living in the rural areas in the city of Ilam (west of Iran). The data were analyzed using the SPSS software version 20 via descriptive statistics, paired t-student test, independent samples t-student test, and ANOVA. Results: Except social role functioning, all aspects of QOL significantly increased after intervention (p<0.001). Regardless of age groups, gender, and educational level the QOL scores increased at follow -up (p<0.001). Conclusions: Education to patients with type 2 diabetes leads to increased means of all dimensions of QOL that reflect the effects of educational interventions on each domain.