University entrepreneurship is an idea that has gained a significant amount of support globally in the last 30 years and is seen as promoting reinvention, revitalisation, and simply remuneration for the universities themselves and their regions at large. But as universities begin to ramp up their technology transfer activities and start to commercialise their research, it is important to consider the regional context and the regional impacts that this can have. Technology transfer is important, but to truly transform economic “catch-up” regions to future leading regions, it cannot be the only goal of university entrepreneurship. As a result, larger perspective and more government, business, and university collaboration is needed. Using Poland as a focus area, this paper will summarise the concept and development of the entrepreneurial university and the policies needed for success, and show that the technology transfer activity of the university should be considered just one element of regional development strategies. It concludes with policy recommendations that may be useful for Poland and other regions.